Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid - for molecular biology,≥99.0%, high purity , CAS No.67-42-5

12 Citations
Item Number
E104434
Grouped product items
SKUSizeAvailabilityPrice Qty
E104434-5g
5g
In stock
$55.90
E104434-25g
25g
In stock
$137.90
E104434-100g
100g
In stock
$309.90
E104434-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$927.90
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Protease inhibitors

Basic Description

Synonyms[Ethylenebis(oxyethylenenitrilo)]tetraacetic acid | ACETIC ACID, (ETHYLENEBIS(OXYETHYLENENITRILO))TETRA- | Acido egtazico [INN-Spanish] | 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioic acid | Ethylene glycol-bis(2-aminoethyl)-N,N,N',N'
Specifications & Purityfor molecular biology, ≥99%
Shipped InNormal
Gradefor molecular biology
Product Description

EGTA (Ethylene Glycol Tetraacetic Acid) is a useful chemical in a variety of buffers. EGTA is a chelating agent that can be used for the determination of calcium in the presence of magnesium since EGTA has greater specificity for calcium ions. EGTA is also useful in ELISA reactions as an inhibitor of alkaline phosphatase activity. EGTA has also been shown to activate Ca2+-stimulated ATPase in rat liver plasma membranes and induce apoptosis in PC12 cells. It also inhibits the zinc-dependent endopeptidases, MMPs (Matrix metalloproteinases).

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C19 Tchem Cytochrome P450 2C19 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DRD1 Tclin D(1A) dopamine receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP3A4 Tclin Cytochrome P450 3A4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C9 Tchem Cytochrome P450 2C9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PMP22 Tbio Peripheral myelin protein 22 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
BLM Tchem Bloom syndrome protein (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ARSA Tbio Arylsulfatase A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nfo Endonuclease 4 (425 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ryanodien receptor (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-[2-[2-[2-[bis(carboxymethyl)amino]ethoxy]ethoxy]ethyl-(carboxymethyl)amino]acetic acid
INCHI InChI=1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
InChi Key DEFVIWRASFVYLL-UHFFFAOYSA-N
Canonical SMILES C(COCCOCCN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O
Isomeric SMILES C(COCCOCCN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O
WGK Germany 2
RTECS AH3760000
PubChem CID 6207
Molecular Weight 380.35
Beilstein 1717370
Reaxy-Rn 1717370

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

19 results found

Lot NumberCertificate TypeDateItem
K2210273Certificate of AnalysisAug 13, 2024 E104434
G2230258Certificate of AnalysisMay 15, 2024 E104434
G2230263Certificate of AnalysisMay 15, 2024 E104434
K2303269Certificate of AnalysisOct 09, 2023 E104434
K2303267Certificate of AnalysisOct 09, 2023 E104434
K2303254Certificate of AnalysisOct 09, 2023 E104434
K2303268Certificate of AnalysisOct 08, 2023 E104434
K2110702Certificate of AnalysisAug 02, 2023 E104434
K2110669Certificate of AnalysisAug 02, 2023 E104434
K2110701Certificate of AnalysisAug 02, 2023 E104434
A2309449Certificate of AnalysisJan 17, 2023 E104434
B2309176Certificate of AnalysisJun 09, 2022 E104434
G2230264Certificate of AnalysisJun 09, 2022 E104434
E2327638Certificate of AnalysisJun 09, 2022 E104434
G2307696Certificate of AnalysisOct 11, 2021 E104434
K2214089Certificate of AnalysisOct 11, 2021 E104434
F2209153Certificate of AnalysisOct 11, 2021 E104434
E2310064Certificate of AnalysisOct 11, 2021 E104434
B2309238Certificate of AnalysisOct 11, 2021 E104434

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Chemical and Physical Properties

SensitivityMoisture sensitive.
Melt Point(°C)241°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 2
RTECS AH3760000
Reaxy-Rn 1717370
Merck Index 3529

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Citations of This Product

1. Qiyue Wang, Tao Wang, Shengfei Yang, Hui Du, Bo Zhang, Sirui Cui, Daishun Ling, Fangyuan Li.  (2023)  Highly Sensitive Diagnosis of Extracellular Calcium Ions Associated Brain Diseases using Ca2+-Dependent T2-T1 Switchable Magnetic Nanosensors.  ADVANCED FUNCTIONAL MATERIALS,    (2313286).  [PMID:]
2. Ji Wang, Xu-Hui Huang, Yu-Ying Zhang, Chengzhen Nie, Dayong Zhou, Lei Qin.  (2024)  Mechanism of salt effect on flavor formation in lightly-salted large yellow croaker by integrated multiple intelligent sensory and untargeted lipidomics analyses.  FOOD CHEMISTRY,  435  (9): (137542).  [PMID:37742462]
3. Qiaoyu Liu, Menglin Lei, Jianjun Lin, Wenhong Zhao, Xiaofang Zeng, Weidong Bai.  (2023)  The roles of lipoxygenases and autoxidation during mackerel (Scomberomorus niphonius) dry-cured processing.  FOOD RESEARCH INTERNATIONAL,  173  (113309).  [PMID:37803620]
4. Qiaoyu Liu, Menglin Lei, Wenhong Zhao, Xiangluan Li, Xiaofang Zeng, Weidong Bai.  (2023)  Formation of Lipid-Derived Flavors in Dry-Cured Mackerel (Scomberomorus niphonius) via Simulation of Autoxidation and Lipoxygenase-Induced Fatty Acid Oxidation.  Foods,  12  (13): (2504).  [PMID:37444242]
5. Zhiwei Huang, Changju Chun, Xinze Li.  (2023)  Kidney targeting peptide-modified biomimetic nanoplatforms for treatment of acute kidney injury.  JOURNAL OF CONTROLLED RELEASE,  358  (368).  [PMID:37121517]
6. Jingwen Wang, Qiyuan Lu, Junming Gong, Fei Gao, Xinglian Xu, Huhu Wang.  (2023)  Magnetic field-assisted cascade effects of improving the quality of gels-based meat products: A mechanism from myofibrillar protein gelation.  FOOD RESEARCH INTERNATIONAL,  169  (112907).  [PMID:37254342]
7. Li Ting, Jiang Shuhui, Zhang Ying, Luo Jie, Li Ming, Ke Hengte, Deng Yibin, Yang Tao, Sun Xiaohui, Chen Huabing.  (2023)  Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation.  Nature Communications,  14  (1): (1-25).  [PMID:37120615]
8. Zhe Chen, Yunxia Wang.  (2023)  A label- and enzyme-free fluorescence assay based on thioflavin T–induced G-quadruplexes for the detection of telomerase activity.  JOURNAL OF CHEMICAL RESEARCH,      [PMID:]
9. Shuai Liu, Yuwei Gao, Lin Quan, Mei Yang, Yong-Zhong Wang, Changjun Hou.  (2022)  Improvement of Lignocellulolytic Enzyme Production Mediated by Calcium Signaling in Bacillus subtilis Z2 under Graphene Oxide Stress.  APPLIED AND ENVIRONMENTAL MICROBIOLOGY,  88  (19):   [PMID:36121214]
10. Zhang Zhen, Zhang Haotian, Woon Kok Sin, Zhu Xiaohu, Sui Yuhong, Luo Zifeng, Chen Lili, Yang Xiaoming, Gao Junyi, Wen Hongping, Jing Ran, Liu Tongzhou.  (2022)  Amendment-Enhanced Phytoextraction of Cadmium from Contaminated Soil Integrating with Ramie as Hyperaccumulator Plant.  WATER AIR AND SOIL POLLUTION,  233  (9): (1-16).  [PMID:]
11. Haihua Shang, Yinghui Sun, Ze Wang, Ying Zhou, Huajiao Yang, Xiaoyan Ci, Tao Cui, Yuanyuan Xia, Yuan Gu, Maoliang Liao, Quansheng Li, Duanyun Si, Changxiao Liu.  (2022)  Intestinal absorption mechanism of rotundic acid: Involvement of P-gp and OATP2B1.  JOURNAL OF ETHNOPHARMACOLOGY,  289  (115006).  [PMID:35051604]
12. Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF et al..  (2018)  Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility..  Elife,  (3): (589-97).  [PMID:29393851]

References

1. Qiyue Wang, Tao Wang, Shengfei Yang, Hui Du, Bo Zhang, Sirui Cui, Daishun Ling, Fangyuan Li.  (2023)  Highly Sensitive Diagnosis of Extracellular Calcium Ions Associated Brain Diseases using Ca2+-Dependent T2-T1 Switchable Magnetic Nanosensors.  ADVANCED FUNCTIONAL MATERIALS,    (2313286).  [PMID:]
2. Ji Wang, Xu-Hui Huang, Yu-Ying Zhang, Chengzhen Nie, Dayong Zhou, Lei Qin.  (2024)  Mechanism of salt effect on flavor formation in lightly-salted large yellow croaker by integrated multiple intelligent sensory and untargeted lipidomics analyses.  FOOD CHEMISTRY,  435  (9): (137542).  [PMID:37742462]
3. Qiaoyu Liu, Menglin Lei, Jianjun Lin, Wenhong Zhao, Xiaofang Zeng, Weidong Bai.  (2023)  The roles of lipoxygenases and autoxidation during mackerel (Scomberomorus niphonius) dry-cured processing.  FOOD RESEARCH INTERNATIONAL,  173  (113309).  [PMID:37803620]
4. Qiaoyu Liu, Menglin Lei, Wenhong Zhao, Xiangluan Li, Xiaofang Zeng, Weidong Bai.  (2023)  Formation of Lipid-Derived Flavors in Dry-Cured Mackerel (Scomberomorus niphonius) via Simulation of Autoxidation and Lipoxygenase-Induced Fatty Acid Oxidation.  Foods,  12  (13): (2504).  [PMID:37444242]
5. Zhiwei Huang, Changju Chun, Xinze Li.  (2023)  Kidney targeting peptide-modified biomimetic nanoplatforms for treatment of acute kidney injury.  JOURNAL OF CONTROLLED RELEASE,  358  (368).  [PMID:37121517]
6. Jingwen Wang, Qiyuan Lu, Junming Gong, Fei Gao, Xinglian Xu, Huhu Wang.  (2023)  Magnetic field-assisted cascade effects of improving the quality of gels-based meat products: A mechanism from myofibrillar protein gelation.  FOOD RESEARCH INTERNATIONAL,  169  (112907).  [PMID:37254342]
7. Li Ting, Jiang Shuhui, Zhang Ying, Luo Jie, Li Ming, Ke Hengte, Deng Yibin, Yang Tao, Sun Xiaohui, Chen Huabing.  (2023)  Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation.  Nature Communications,  14  (1): (1-25).  [PMID:37120615]
8. Zhe Chen, Yunxia Wang.  (2023)  A label- and enzyme-free fluorescence assay based on thioflavin T–induced G-quadruplexes for the detection of telomerase activity.  JOURNAL OF CHEMICAL RESEARCH,      [PMID:]
9. Shuai Liu, Yuwei Gao, Lin Quan, Mei Yang, Yong-Zhong Wang, Changjun Hou.  (2022)  Improvement of Lignocellulolytic Enzyme Production Mediated by Calcium Signaling in Bacillus subtilis Z2 under Graphene Oxide Stress.  APPLIED AND ENVIRONMENTAL MICROBIOLOGY,  88  (19):   [PMID:36121214]
10. Zhang Zhen, Zhang Haotian, Woon Kok Sin, Zhu Xiaohu, Sui Yuhong, Luo Zifeng, Chen Lili, Yang Xiaoming, Gao Junyi, Wen Hongping, Jing Ran, Liu Tongzhou.  (2022)  Amendment-Enhanced Phytoextraction of Cadmium from Contaminated Soil Integrating with Ramie as Hyperaccumulator Plant.  WATER AIR AND SOIL POLLUTION,  233  (9): (1-16).  [PMID:]
11. Haihua Shang, Yinghui Sun, Ze Wang, Ying Zhou, Huajiao Yang, Xiaoyan Ci, Tao Cui, Yuanyuan Xia, Yuan Gu, Maoliang Liao, Quansheng Li, Duanyun Si, Changxiao Liu.  (2022)  Intestinal absorption mechanism of rotundic acid: Involvement of P-gp and OATP2B1.  JOURNAL OF ETHNOPHARMACOLOGY,  289  (115006).  [PMID:35051604]
12. Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF et al..  (2018)  Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility..  Elife,  (3): (589-97).  [PMID:29393851]

Solution Calculators