Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity. Etiocholanolone is a less potentxa0neurosteroid positive allosteric modulatorxa0(PAM) of the GABA A receptor than itsxa0enantiomer form
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Product Description
Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABA A receptor than its enantiomer form .
In Vitro
Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it is ineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50 values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
