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Etoricoxib - ≥98.0%, high purity , Cyclooxygenase-2 inhibitor, CAS No.202409-33-4, Cyclooxygenase-2 inhibitor
Basic Description Synonyms Etoricoxib|202409-33-4|Arcoxia|Tauxib|Nucoxia|Algix|MK-0663|5-Chloro-6'-methyl-3-(4-(methylsulfonyl)phenyl)-2,3'-bipyridine|MK-663|L-791456|MK 0663|2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-|5-chloro-6'-methyl-3-[4-(methylsulfonyl)p Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Etoricoxib is a specific inhibitor of COX-2(Cyclooxygenase-2) Storage Temp Store at 2-8°C,Argon charged Shipped In Wet ice Grade Moligand™ Action Type INHIBITOR Mechanism of action Cyclooxygenase-2 inhibitor Note 10mg售完停产，不再备货 Product Description EtoricoxibEtoricoxib(MK-0663) selectively inhibited COX-2 in human whole blood assays in vitro, with an IC50 value of1.1 ± 0.1 μM for COX-2 (LPS-induced prostaglandin E2 synthesis), compared with an IC50 value of 116 ± 8 μM for COX-1 (serum thromboxane B2 generation after clotting of the blood).
Names and Identifiers IUPAC Name 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine INCHI InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3 InChi Key MNJVRJDLRVPLFE-UHFFFAOYSA-N Canonical SMILES CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C Isomeric SMILES CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C WGK Germany 3 PubChem CID 123619 Molecular Weight 358.84 Beilstein 8073797
Chemical and Physical Properties Solubility Soluble in DMSO, and methanol
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H302: Harmful if swallowed
H310: Fatal in contact with skin
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
WGK Germany 3
References 1. Wang R. (2021) Etoricoxib may inhibit cytokine storm to treat COVID-19.. Med Hypotheses, 150 (3): (110557). [PMID:33730601 ]
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