L2021230Determine the necessary mass, volume, or concentration for preparing a solution.
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Basic Description
| Synonyms | XE178590 | AS-15078 | HY-N0114A | NCGC00163553-02 | SureCN682158 | FT-0651829 | Evodiamine, Evodia rutaecarpa | NSC258314 | NSC-258314 | Evodiamine; | NCGC00163553-03 | Q5418554 | PubChem18244 | (1S)-21-methyl-3,13,21-triazapentacyclo[11.8.0.0^{2,10.0^{4, |
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| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | The interferon-γ priming signal regulating the transcriptional activation of the iNOS gene is blocked by Evodiamine, suppressing iNOS protein synthesis but not affecting iNOS function. Evodiamine also demonstrates antiangiogenesis through inhibition of va |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects. |
Associated Targets(Human)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
TOP1 Tclin DNA topoisomerase I (7553 Activities)
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TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)
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ACHE Tclin Acetylcholinesterase (18204 Activities)
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PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
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RXRA Tclin Retinoid X receptor alpha (3637 Activities)
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TRPV1 Tclin Vanilloid receptor (8273 Activities)
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Caco-2 (12174 Activities)
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HL-60 (67320 Activities)
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Huh-7 (12904 Activities)
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MCF-10A (2462 Activities)
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MCF7 (126967 Activities)
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PC-3 (62116 Activities)
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SGC-7901 (2773 Activities)
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SK-HEP1 (1155 Activities)
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THP-1 (11052 Activities)
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A549 (127892 Activities)
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Bel-7402 (4577 Activities)
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HCT-116 (91556 Activities)
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HEK293 (82097 Activities)
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HepG2 (196354 Activities)
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MDA-MB-435 (38290 Activities)
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MDA-MB-231 (73002 Activities)
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PBMC (10003 Activities)
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SMMC-7721 (5516 Activities)
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SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
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L02 (4864 Activities)
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Associated Targets(non-human)
PDE6C Phosphodiesterase 6C (1 Activities)
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Hdac6 Histone deacetylase 6 (222 Activities)
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Mus musculus (284745 Activities)
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Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)
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BCHE Cholinesterase (8742 Activities)
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Mechanisms of Action
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Names and Identifiers
| IUPAC Name | 21-methyl-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15,17,19-heptaen-14-one |
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| INCHI | InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3 |
| InChi Key | TXDUTHBFYKGSAH-UHFFFAOYSA-N |
| Canonical SMILES | CN1C2C3=C(CCN2C(=O)C4=CC=CC=C41)C5=CC=CC=C5N3 |
| Isomeric SMILES | CN1C2C3=C(CCN2C(=O)C4=CC=CC=C41)C5=CC=CC=C5N3 |
| PubChem CID | 151289 |
| Molecular Weight | 303.37 |
| Reaxy-Rn | 94484 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Solubility | Soluble in DMSO (5 mg/mL,warm to 40°C), water (<1 mg/mL) at 25 °C, and ethanol (<1 mg/mL) at 25 °C |
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| Sensitivity | Light sensitive. |
| Melt Point(°C) | 272°C(lit.) |
Safety and Hazards(GHS)
| Reaxy-Rn | 94484 |
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