example 373 [WO2012093101] , CAS No.E610249, Inhibitor of complement factor D

Item Number
E610249
Grouped product items
SKUSizeAvailabilityPrice Qty
E610249-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$600.90
E610249-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of complement factor D

Associated Targets(Human)

CFD Tchem Complement factor D (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Complement factor D inhibitorINHIBITORALA2176771Complement factor DSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Complement factor D inhibitorINHIBITORALA2176771Complement factor DSINGLE PROTEINHomo sapiens

Other: [1]


PubMed: [1]


Names and Identifiers

IUPAC Name (1R,3S,5R)-2-N-[1-carbamoyl-5-(cyanomethoxy)indol-3-yl]-3-N-[(3-chloro-2-fluorophenyl)methyl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamide
INCHI InChI=1S/C25H22ClFN6O4/c26-17-3-1-2-13(22(17)27)11-30-23(34)21-9-14-8-20(14)33(21)25(36)31-18-12-32(24(29)35)19-5-4-15(10-16(18)19)37-7-6-28/h1-5,10,12,14,20-21H,7-9,11H2,(H2,29,35)(H,30,34)(H,31,36)/t14-,20-,21+/m1/s1
InChi Key SOCAXRLFGRNEPK-IFZYUDKTSA-N
Canonical SMILES N#CCOc1ccc2c(c1)c(NC(=O)N1[C@@H]3C[C@@H]3C[C@H]1C(=O)NCc1cccc(c1F)Cl)cn2C(=O)N
Isomeric SMILES C1[C@H]2[C@@H]1N([C@@H](C2)C(=O)NCC3=C(C(=CC=C3)Cl)F)C(=O)NC4=CN(C5=C4C=C(C=C5)OCC#N)C(=O)N
PubChem CID 57412074

Certificates

C of A & Other Certificates(BSE/TSE, COO)

Related Documents

References

1. Abdel-Magid AF.  (2012)  Factor D Inhibitors for the Treatment of AMD: Patent Highlight..  ACS Med Chem Lett,  (10): (781-2).  [PMID:24900375] [10.1021/op500134e]

Solution Calculators