Exendin-4, a 39 amino acid peptide, activates GLP-1 (Glukagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors. Exendin-4 stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS ac
Storage Temp
Protected from light,Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of GLP-1 receptor
Note
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Exendin-4 is an incretin mimetic peptide, which is composed of 39 amino acids. It is an analog of glucagon-like peptide 1 (GLP-1), and an insulinotropic agent, with a long half-life. It was originally isolated from the venom of Gila monster lizard called Heloderma suspectum.
1.Bond A. (2006) Exenatide (Byetta) as a novel treatment option for type 2 diabetes mellitus.. Proc (Bayl Univ Med Cent), 19 (3):(281-4). [PMID:17252050][10.1021/op500134e]
2.Pan X et al.. (2019) Essential Role Of High Glucose-Induced Overexpression Of PKCß And PKCd In GLP-1 Resistance In Rodent Cardiomyocytes.. Diabetes Metab Syndr Obes, 12 (2289-2302). [PMID:31807042]
3.Pan X et al.. (2021) High Glucose Attenuates Cardioprotective Effects of Glucagon-Like Peptide-1 Through Induction of Mitochondria Dysfunction via Inhibition of ß-Arrestin-Signaling.. Front Physiol, 12 (648399). [PMID:34054568]
4.Brown JD et al.. (2018) Oleoylethanolamide modulates glucagon-like peptide-1 receptor agonist signaling and enhances exendin-4-mediated weight loss in obese mice.. Am J Physiol Regul Integr Comp Physiol, 315 (4):(R595-R608). [PMID:29949410]
5.Géa LP et al.. (2020) Reduction of hippocampal IL-6 levels in LPS-injected rats following acute exendin-4 treatment.. Naunyn Schmiedebergs Arch Pharmacol, 393 (7):(1303-1311). [PMID:32363414]
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