Ezetimibe - ≥99%, high purity , Niemann-Pick C1-like protein 1 inhibitor, CAS No.163222-33-1, Niemann-Pick C1-like protein 1 inhibitor

Item Number

E126609

• Synonyms: Ezetimibe | 163222-33-1 | Zetia | Ezetrol | Ezedoc | Sch 58235 | SCH58235 | (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one | SCH-58235 | (-)-Sch 58235 | ezetimiba | ezetimibum | UNII-EOR26LQQ24 | (3R,4S)-1-(4-fluorophenyl)-
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by Niemann-Pick C1 Like 1 (NPC1L1) protein that was found critical for the intestinal absorption of cholesterol. Ezetimibe selectvely blocks cholesterol absorption witho
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST, INHIBITOR
• Mechanism of action: Niemann-Pick C1-like protein 1 inhibitor
• Note: Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes. Ezetimibe is used clinically to lower plasma cholesterol levels.
A cholesterol transport inhibitor that binds to NPC1L1