ezurpimtrostat , CAS No.1914148-72-3, Inhibitor of palmitoyl-protein thioesterase 1

Item Number
E610266
Grouped product items
SKUSizeAvailabilityPrice Qty
E610266-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$920.90
E610266-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,220.90

Basic Description

SynonymsEzurpimtrostat | Gns 561 | GNS 561 [WHO-DD] | GNS561 | GNS-561 | GTPL11991 | 4-[4-(tert-butylamino)piperidin-1-yl]-N-[(4-chlorophenyl)methyl]quinolin-2-amine | 1914148-72-3 | SCHEMBL17713568 | CS-0143466 | UNII-MS6LGW5JFK | AKOS040757126 | MS6LGW5JFK | 2-
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of palmitoyl-protein thioesterase 1

Associated Targets(Human)

PPT1 Tbio Palmitoyl-protein thioesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-[4-(tert-butylamino)piperidin-1-yl]-N-[(4-chlorophenyl)methyl]quinolin-2-amine
INCHI InChI=1S/C25H31ClN4/c1-25(2,3)29-20-12-14-30(15-13-20)23-16-24(28-22-7-5-4-6-21(22)23)27-17-18-8-10-19(26)11-9-18/h4-11,16,20,29H,12-15,17H2,1-3H3,(H,27,28)
InChi Key QVXSJSXAVQJXOV-UHFFFAOYSA-N
Canonical SMILES CC(C)(C)NC1CCN(CC1)c1cc(nc2ccccc12)NCc1ccc(cc1)Cl
Isomeric SMILES CC(C)(C)NC1CCN(CC1)C2=CC(=NC3=CC=CC=C32)NCC4=CC=C(C=C4)Cl
PubChem CID 121305180

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Related Documents

References

1. Brun S, Pascussi JM, Gifu EP, Bestion E, Macek-Jilkova Z, Wang G, Bassissi F, Mezouar S, Courcambeck J, Merle P et al..  (2021)  GNS561, a New Autophagy Inhibitor Active against Cancer Stem Cells in Hepatocellular Carcinoma and Hepatic Metastasis from Colorectal Cancer..  J Cancer,  12  (18): (5432-5438).  [PMID:34405006] [10.1021/op500134e]
2. Brun S, Bestion E, Raymond E, Bassissi F, Jilkova ZM, Mezouar S, Rachid M, Novello M, Tracz J, Hamaï A et al..  (2022)  GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions..  Autophagy,  18  (3): (678-694).  [PMID:34740311] [10.1021/op500134e]
3. Bestion E, Zandi K, Belouzard S, Andreani J, Lepidi H, Novello M, Rouquairol C, Baudoin JP, Rachid M, La Scola B et al..  (2022)  GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy Inhibition..  Viruses,  14  (1): (1755-70).  [PMID:35062337] [10.3390/v14010132]
4. Brun S, Bassissi F, Serdjebi C, Novello M, Tracz J, Autelitano F, Guillemot M, Fabre P, Courcambeck J, Ansaldi C et al..  (2019)  GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma..  Invest New Drugs,  37  (6): (1135-1145).  [PMID:30778887] [10.1021/op500134e]
5. Halfon P, Bestion E, Zandi K, Andreani J, Baudoin JP, La Scola B, Mege JL, Mezouar S, Schinazi RF.  (2020)  GNS561 exhibits potent in vitro antiviral activity against SARS-CoV-2 through autophagy inhibition..  bioRxiv,  71  (13): (1755-70).  [PMID:33052342] [10.1021/op500134e]

Solution Calculators