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Ezutromid - 98%, high purity , Utrophin modulator, CAS No.945531-77-1, Utrophin modulator

  • Moligand™
  • ≥98%
Item Number
E412372
Grouped product items
SKUSizeAvailabilityPrice Qty
E412372-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$75.90
E412372-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$123.90
E412372-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$249.90
E412372-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
E412372-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$643.90

Basic Description

SynonymsEzutromid | 945531-77-1 | SMT c1100 | BMN-195 | SMT-C1100 | SMTC-1100 | BMN 195 | Ezutromid [INN] | 5-(ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole | 5-ethylsulfonyl-NBO | 5-Ethylsulfonyl-2-naphthalen-2-yl-1,3-benzoxazole | 5-(Ethylsulfonyl)-2-(naphthalen-2-yl)benzo(d)oxa
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsEzutromid (SMT C1100, BMN 195, VOX-C1100) is a novel modulator of Small utrophin's translation with EC50 of 0.4 uM .
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST, MODULATOR
Mechanism of actionUtrophin modulator
Product Description

Information

Ezutromid (SMT C1100, BMN 195, VOX-C1100) is a novel modulator of Small utrophin's translation with EC50 of 0.4 uM .

Product Properties

ALogP4.3

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C8 Tchem Cytochrome P450 2C8 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2B6 Tchem Cytochrome P450 2B6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

UTRN Tchem Utrophin 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABCB1 Tchem Multidrug resistance protein 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

UGT2B28 Tbio UDP-glucuronosyltransferase 2B28 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP1A1 Tchem Cytochrome P450 1A1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABCG2 Tchem ATP-binding cassette sub-family G member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AHR Tclin Aryl hydrocarbon receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-ethylsulfonyl-2-naphthalen-2-yl-1,3-benzoxazole
INCHI InChI=1S/C19H15NO3S/c1-2-24(21,22)16-9-10-18-17(12-16)20-19(23-18)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,2H2,1H3
InChi Key KSGCNXAZROJSNW-UHFFFAOYSA-N
Canonical SMILES CCS(=O)(=O)C1=CC2=C(C=C1)OC(=N2)C3=CC4=CC=CC=C4C=C3
Isomeric SMILES CCS(=O)(=O)C1=CC2=C(C=C1)OC(=N2)C3=CC4=CC=CC=C4C=C3
PubChem CID 25109292
Molecular Weight 337.4

Certificates

Certificate of Analysis(COA)

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7 results found

Lot NumberCertificate TypeDateItem
A2416332Certificate of AnalysisDec 13, 2023 E412372
A2416333Certificate of AnalysisDec 13, 2023 E412372
A2416334Certificate of AnalysisDec 13, 2023 E412372
A2416365Certificate of AnalysisDec 13, 2023 E412372
A2416366Certificate of AnalysisDec 13, 2023 E412372
A2416367Certificate of AnalysisDec 13, 2023 E412372
A2416369Certificate of AnalysisDec 13, 2023 E412372

Chemical and Physical Properties

SolubilityDMSO : 10 mg/mL (29.64 mM)

Related Documents

References

1. Tinsley JM, Fairclough RJ, Storer R, Wilkes FJ, Potter AC, Squire SE, Powell DS, Cozzoli A, Capogrosso RF, Lambert A et al..  (2011)  Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse..  PLoS ONE,  (5): (e19189).  [PMID:21573153]
2. Wilkinson IVL, Perkins KJ, Dugdale H, Moir L, Vuorinen A, Chatzopoulou M, Squire SE, Monecke S, Lomow A, Geese M et al..  (2020)  Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid..  Angew Chem Int Ed Engl,  59  (6): (2420-2428).  [PMID:31755636]

Solution Calculators