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Ezutromid - 98%, high purity , Utrophin modulator, CAS No.945531-77-1, Utrophin modulator

Moligand™

≥98%

CAS#: 945531-77-1
Formula: C₁₉H₁₅NO₃S
Molecular Weight: 337.4
PubChem CID: 25109292

Item Number

E412372

Grouped product items
SKU	Size	Availability	Price
E412372-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$75.90
E412372-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$123.90
E412372-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$249.90
E412372-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$399.90
E412372-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$643.90

View related series

Aryl hydrocarbon receptor Antagonist Cytochrome P450 Metabolic Enzyme/Protease

Basic Description

Synonyms	BMN-195; SMT C1100 \| BMN 195 \| HY-17614 \| AKOS030527030 \| SCHEMBL732212 \| SMT c1100 \| SMTC1100 \| SMT-C1100 \| SMTC-1100 \| CS-5710 \| 5-(ETHANESULFONYL)-2-(NAPHTHALEN-2-YL)-1,3-BENZOXAZOLE \| Benzoxazole, 5-(ethylsulfonyl)-2-(2-naphthalenyl)- \| EX-A2333 \| SMT
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Ezutromid (SMT C1100, BMN 195, VOX-C1100) is a novel modulator of Small utrophin's translation with EC50 of 0.4 uM .
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST, MODULATOR
Mechanism of action	Utrophin modulator
Product Description	Information Ezutromid (SMT C1100, BMN 195, VOX-C1100) is a novel modulator of Small utrophin's translation with EC50 of 0.4 uM .

Associated Targets(Human)

UTRN Tchem Utrophin (2 Activities)

Discover Target: UTRN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AHR Tclin Aryl hydrocarbon receptor (0 Activities)

Discover Target: AHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C8 Tchem Cytochrome P450 2C8 (1492 Activities)

Discover Target: CYP2C8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AHR Tclin Aryl hydrocarbon receptor (1071 Activities)

Discover Target: AHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)

Discover Target: CYP1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2B6 Tchem Cytochrome P450 2B6 (1338 Activities)

Discover Target: CYP2B6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCG2 Tchem ATP-binding cassette sub-family G member 2 (4927 Activities)

Discover Target: ABCG2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsomes (16955 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver (3974 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UTRN Tchem Utrophin (89 Activities)

Discover Target: UTRN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)

Discover Target: Abcb1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	5-ethylsulfonyl-2-naphthalen-2-yl-1,3-benzoxazole
INCHI	InChI=1S/C19H15NO3S/c1-2-24(21,22)16-9-10-18-17(12-16)20-19(23-18)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,2H2,1H3
InChi Key	KSGCNXAZROJSNW-UHFFFAOYSA-N
Canonical SMILES	CCS(=O)(=O)C1=CC2=C(C=C1)OC(=N2)C3=CC4=CC=CC=C4C=C3
Isomeric SMILES	CCS(=O)(=O)C1=CC2=C(C=C1)OC(=N2)C3=CC4=CC=CC=C4C=C3
PubChem CID	25109292
Molecular Weight	337.4

PubChem CID

ChEMBL Ligand

DrugBank Ligand

CAS Registry No.

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
A2416332	Certificate of Analysis	Dec 13, 2023	E412372
A2416333	Certificate of Analysis	Dec 13, 2023	E412372
A2416334	Certificate of Analysis	Dec 13, 2023	E412372
A2416365	Certificate of Analysis	Dec 13, 2023	E412372
A2416366	Certificate of Analysis	Dec 13, 2023	E412372
A2416367	Certificate of Analysis	Dec 13, 2023	E412372
A2416369	Certificate of Analysis	Dec 13, 2023	E412372

References

1. Tinsley JM, Fairclough RJ, Storer R, Wilkes FJ, Potter AC, Squire SE, Powell DS, Cozzoli A, Capogrosso RF, Lambert A et al.. (2011) Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse.. PLoS ONE, 6 (5): (e19189). [PMID:21573153] [10.1021/op500134e]
2. Wilkinson IVL, Perkins KJ, Dugdale H, Moir L, Vuorinen A, Chatzopoulou M, Squire SE, Monecke S, Lomow A, Geese M et al.. (2020) Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.. Angew Chem Int Ed Engl, 59 (6): (2420-2428). [PMID:31755636] [10.1021/op500134e]

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Ezutromid - 98%, high purity , Utrophin modulator, CAS No.945531-77-1, Utrophin modulator

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

References

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