Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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F100149-1g | 1g | In stock | $58.90 | |
F100149-5g | 5g | In stock | $82.90 | |
F100149-25g | 25g | In stock | $336.90 | |
F100149-100g | 100g | In stock | $1,210.90 | |
F100149-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $5,445.90 |
RNA and DNA synthesis inhibitor. Anticancer agent.
Synonyms | 5-FU | 5-Fluorouracil-6-d1 | fluorouracil | NSC19893 | NSC-19893 | 5-Fluoracil | Cinco FU | Fluro Uracil | U3P01618RT | 5-Fluor-2,4(1H,3H)-pyrimidindion | 5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione | FU | AI3-25297 | Fluorouracile [DCIT] | HSDB 3228 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | 5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | RNA inhibitor |
Note | 1g卖完停产,不再备货Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Pubchem Sid | 488179764 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179764 |
IUPAC Name | 5-fluoro-1H-pyrimidine-2,4-dione |
INCHI | InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9) |
InChi Key | GHASVSINZRGABV-UHFFFAOYSA-N |
Canonical SMILES | C1=C(C(=O)NC(=O)N1)F |
Isomeric SMILES | C1=C(C(=O)NC(=O)N1)F |
WGK Germany | 3 |
RTECS | YR0350000 |
PubChem CID | 3385 |
Molecular Weight | 130.08 |
Beilstein | 127172 |
Reaxy-Rn | 127172 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2406187 | Certificate of Analysis | Mar 23, 2024 | F100149 |
F2406188 | Certificate of Analysis | Mar 23, 2024 | F100149 |
I2307513 | Certificate of Analysis | Aug 24, 2023 | F100149 |
I2307514 | Certificate of Analysis | Aug 24, 2023 | F100149 |
I2307515 | Certificate of Analysis | Aug 24, 2023 | F100149 |
L2312019 | Certificate of Analysis | Nov 21, 2022 | F100149 |
L2209512 | Certificate of Analysis | Nov 21, 2022 | F100149 |
L2209500 | Certificate of Analysis | Nov 21, 2022 | F100149 |
L2209422 | Certificate of Analysis | Nov 21, 2022 | F100149 |
L2209421 | Certificate of Analysis | Nov 21, 2022 | F100149 |
L2209326 | Certificate of Analysis | Nov 21, 2022 | F100149 |
L2209319 | Certificate of Analysis | Nov 21, 2022 | F100149 |
L2209316 | Certificate of Analysis | Nov 21, 2022 | F100149 |
G2311074 | Certificate of Analysis | Nov 21, 2022 | F100149 |
D2312006 | Certificate of Analysis | Nov 21, 2022 | F100149 |
B2309110 | Certificate of Analysis | Nov 21, 2022 | F100149 |
I2220091 | Certificate of Analysis | Nov 27, 2021 | F100149 |
I2220086 | Certificate of Analysis | Nov 27, 2021 | F100149 |
B2309109 | Certificate of Analysis | Nov 27, 2021 | F100149 |
Solubility | Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.Water solubility: 12.2 g/L (20°C) |
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Sensitivity | Light sensitive. |
Boil Point(°C) | 190 - 200 °C / 374 - 392 °F@ 0.1 mmHg |
Melt Point(°C) | 278 - 282 °C / 532.4 - 539.6 °F |
Pictogram(s) | GHS06, GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H412:Harmful to aquatic life with long lasting effects H312:Harmful in contact with skin H360:May damage fertility or the unborn child H340:May cause genetic defects |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | YR0350000 |
Reaxy-Rn | 127172 |
Merck Index | 4181 |
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28. Huanli Yin, Qi Yan, Yuan Liu, Lan Yang, Yang Liu, Yujie Luo, Tianyu Chen, Ningxi Li, Min Wu. (2022) Co-encapsulation of paclitaxel and 5-fluorouracil in folic acid-modified, lipid-encapsulated hollow mesoporous silica nanoparticles for synergistic breast cancer treatment. RSC Advances, 12 (50): (32534-32551). [PMID:36425719] |
29. Yue-Ming Yu, Fan-Zhi Bu, Su-Su Meng, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li. (2022) The first marine dual-drug cocrystal of cytarabine with 5-fluorouracil having synergistic antitumor effects shows superior biopharmaceutical peculiarities by oral administration. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 629 (122386). [PMID:36372139] |
30. Liang Qin, Fenglan Liang, Yan Li, Jiana Wu, Shiyuan Guan, Meiyin Wu, Shiling Xie, Manshi Luo, Deyun Ma. (2022) A 2D Porous Zinc-Organic Framework Platform for Loading of 5-Fluorouracil. Inorganics, 10 (11): (202). [PMID:] |
31. Yang Bingxue, Xie Xinran, Lv Dazhao, Hu Jiajun, Chen Yuyun, Wu Zhaoyu, Luo Shuyue, Zhang Shiyi. (2022) Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil. BRITISH JOURNAL OF CANCER, 128 (2): (219-231). [PMID:36347964] |
32. Zhang Shiyu, Mi Yinxiao, Ye Tingting, Lu Xiaoyan, Liu Li, Qian Jing, Fan Xiaohui. (2022) Carbohydrates and ginsenosides in shenmai injection jointly improve hematopoietic function during chemotherapy-induced myelosuppression in mice. Chinese Medicine, 17 (1): (1-15). [PMID:36333798] |
33. Wang Mi, Shen Yanting, Hu Xiaoxiao, Zhu Yanyan, Wang Jing. (2022) Colorimetric/SERS dual-channel nanoprobe for reactive oxygen species monitoring in elucidating the mechanism of chemotherapeutic drugs action on cancer cells. MICROCHIMICA ACTA, 189 (9): (1-11). [PMID:36008738] |
34. Yanyan Wang, Liuqian Bao, Jiajing Sun, Yuanyuan Ding, Jiasheng Shi, Zhengyu Duan, Zhiyong Chen. (2022) Superhydrophobic fluorinated microspheres for fluorous affinity chromatography. JOURNAL OF CHROMATOGRAPHY A, 1680 (463428). [PMID:36001909] |
35. Huixia Feng, Guilin Chen, Yongli Zhang, Mingquan Guo. (2022) Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2. Journal of Inflammation Research, 15 ( 4677–4692). [PMID:35996684] |
36. Dongsheng Fu, Jinhui You, Ruijie Guo, Jie Zhang, Qiang Li, Jing Wen, Huifang Wang, Hong Yan. (2022) Preparation of Nanostructured Graphene Oxide and Its Application in Drug Loading and Sustained Release. ChemistrySelect, 7 (30): (e202200670). [PMID:] |
37. Tianyu Chen, Hui Chen, Yichun Jiang, Qi Yan, Shuling Zheng, Min Wu. (2022) Co-Delivery of 5-Fluorouracil and Paclitaxel in Mitochondria-Targeted KLA-Modified Liposomes to Improve Triple-Negative Breast Cancer Treatment. Pharmaceuticals, 15 (7): (881). [PMID:35890181] |
38. Ya-Hui Yu, Li Wang, Qiang Zhang, Xiao-Nan Zhang, Xin-Huai Zhao. (2022) Activities of the soluble and non-digestible longan (Dimocarpus longan Lour.) polysaccharides against HCT-116 cells as affected by a chemical selenylation. Current Research in Food Science, 5 (1071). [PMID:35799859] |
39. Xiaofei Liao, Mengyan Li, Li Zou. (2022) Target-induced activation of DNAzyme for highly sensitive colorimetric detection of bleomycin via DNA scission. RSC Advances, 12 (29): (18296-18300). [PMID:35799941] |
40. Hanwen Liu, Ying Liu, Ting Zhou, Penghui Zhou, Jianguo Li, Anping Deng. (2022) Ultrasensitive and Specific Detection of Anticancer Drug 5-Fluorouracil in Blood Samples by a Surface-Enhanced Raman Scattering (SERS)-Based Lateral Flow Immunochromatographic Assay. MOLECULES, 27 (13): (4019). [PMID:35807264] |
41. Kun Fang, Sha Du, Dachuan Shen, Zhipeng Xiong, Ke Jiang, Dapeng Liang, Jianxin Wang, Huizhe Xu, Lulu Hu, Xingyue Zhai, Yuting Jiang, Zhiyu Xia, Chunrui Xie, Di Jin, Wei Cheng, Songshu Meng, Yifei Wang. (2022) SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway. iScience, 25 (104618). [PMID:35800779] |
42. Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang. (2022) Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (12): (6597). [PMID:35743042] |
43. Ting Zhou, Guangzhao He, Changjia Hu, Kang Wu, Ying Liu, Jianguo Li, Anping Deng. (2022) Development of a highly sensitive and specific monoclonal antibody-based ELISA coupled with immuno-affinity extraction for the detection of anticancer drug 5-fluorouracil in blood samples. TALANTA, 249 (123655). [PMID:35696979] |
44. Li Cheng, Fang Wang, Yuanxin Cao, Chaoying Tong, Qisheng Wei, Shuyun Shi, Ying Guo. (2022) Rapid profiling of potential antitumor polymethoxylated flavonoids in natural products by integrating cell biospecific extraction with neutral loss/diagnostic ion filtering-based high-performance liquid chromatography–quadrupole time-of-flight tandem mass spectrometry. PHYTOCHEMICAL ANALYSIS, 33 (6): (895-905). [PMID:35668040] |
45. Hao Guo, Songjie Fan, Jianhua Liu, Yumei Wang. (2022) A dual-pH sensitive drug release system for combinatorial delivery of 5‑fluorouracil and leucovorin calcium in colon cancer therapy. INORGANIC CHEMISTRY COMMUNICATIONS, 141 (109616). [PMID:] |
46. Jieping Zhang, Shaomin Zou, Yijing Zhang, Ziqing Yang, Wencong Wang, Manqi Meng, Junyan Feng, Peng Zhang, Lishi Xiao, Mong-Hong Lee, Lekun Fang. (2022) 3,3′-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer. Metabolites, 12 (5): (410). [PMID:35629914] |
47. Ya-Hui Yu, Zhi-Mei Tang, Cen Xiong, Fei-Fei Wu, Jun-Ren Zhao, Xin-Huai Zhao. (2022) Enhanced Growth Inhibition and Apoptosis Induction in Human Colon Carcinoma HT-29 Cells of Soluble Longan Polysaccharides with a Covalent Chemical Selenylation. Nutrients, 14 (9): (1710). [PMID:35565676] |
48. Ting Ge, Zhang Weiwei, Fei Ge, Longbao Zhu, Ping Song, Wanzheng Li, Lin Gui, Wan Dong, Yugui Tao, Kai Yang. (2022) A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis. Biomaterials Science, 10 (7): (1831-1843). [PMID:35253030] |
49. Fengzhe Li, Yingying Chen, Jinhua Shang, Qing Wang, Shizhen He, Xiwen Xing, Fuan Wang. (2022) An Isothermal Autocatalytic Hybridization Reaction Circuit for Sensitive Detection of DNA Methyltransferase and Inhibitors Assay. ANALYTICAL CHEMISTRY, 94 (10): (4495–4503). [PMID:35234458] |
50. Wang Shuang, Wang Chen, Xin Yuxiao, Li Qiuyun, Liu Weilu. (2022) Core–shell nanocomposite of flower-like molybdenum disulfide nanospheres and molecularly imprinted polymers for electrochemical detection of anti COVID-19 drug favipiravir in biological samples. MICROCHIMICA ACTA, 189 (3): (1-9). [PMID:35229221] |
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53. Zhipeng Jiang, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen. (2022) Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance. Bioengineered, 13 (1): (810-823). [PMID:34974791] |
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57. Feng Huixia, Chen Guilin, Zhang Yongli, Guo Mingquan. (2021) Exploring Multifunctional Bioactive Components from Podophyllum sinense Using Multi-Target Ultrafiltration. Frontiers in Pharmacology, 12 [PMID:34759823] |
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31. Liang Qin, Fenglan Liang, Yan Li, Jiana Wu, Shiyuan Guan, Meiyin Wu, Shiling Xie, Manshi Luo, Deyun Ma. (2022) A 2D Porous Zinc-Organic Framework Platform for Loading of 5-Fluorouracil. Inorganics, 10 (11): (202). [PMID:] |
32. Yang Bingxue, Xie Xinran, Lv Dazhao, Hu Jiajun, Chen Yuyun, Wu Zhaoyu, Luo Shuyue, Zhang Shiyi. (2022) Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil. BRITISH JOURNAL OF CANCER, 128 (2): (219-231). [PMID:36347964] |
33. Zhang Shiyu, Mi Yinxiao, Ye Tingting, Lu Xiaoyan, Liu Li, Qian Jing, Fan Xiaohui. (2022) Carbohydrates and ginsenosides in shenmai injection jointly improve hematopoietic function during chemotherapy-induced myelosuppression in mice. Chinese Medicine, 17 (1): (1-15). [PMID:36333798] |
34. Wang Mi, Shen Yanting, Hu Xiaoxiao, Zhu Yanyan, Wang Jing. (2022) Colorimetric/SERS dual-channel nanoprobe for reactive oxygen species monitoring in elucidating the mechanism of chemotherapeutic drugs action on cancer cells. MICROCHIMICA ACTA, 189 (9): (1-11). [PMID:36008738] |
35. Yanyan Wang, Liuqian Bao, Jiajing Sun, Yuanyuan Ding, Jiasheng Shi, Zhengyu Duan, Zhiyong Chen. (2022) Superhydrophobic fluorinated microspheres for fluorous affinity chromatography. JOURNAL OF CHROMATOGRAPHY A, 1680 (463428). [PMID:36001909] |
36. Huixia Feng, Guilin Chen, Yongli Zhang, Mingquan Guo. (2022) Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2. Journal of Inflammation Research, 15 ( 4677–4692). [PMID:35996684] |
37. Dongsheng Fu, Jinhui You, Ruijie Guo, Jie Zhang, Qiang Li, Jing Wen, Huifang Wang, Hong Yan. (2022) Preparation of Nanostructured Graphene Oxide and Its Application in Drug Loading and Sustained Release. ChemistrySelect, 7 (30): (e202200670). [PMID:] |
38. Tianyu Chen, Hui Chen, Yichun Jiang, Qi Yan, Shuling Zheng, Min Wu. (2022) Co-Delivery of 5-Fluorouracil and Paclitaxel in Mitochondria-Targeted KLA-Modified Liposomes to Improve Triple-Negative Breast Cancer Treatment. Pharmaceuticals, 15 (7): (881). [PMID:35890181] |
39. Ya-Hui Yu, Li Wang, Qiang Zhang, Xiao-Nan Zhang, Xin-Huai Zhao. (2022) Activities of the soluble and non-digestible longan (Dimocarpus longan Lour.) polysaccharides against HCT-116 cells as affected by a chemical selenylation. Current Research in Food Science, 5 (1071). [PMID:35799859] |
40. Xiaofei Liao, Mengyan Li, Li Zou. (2022) Target-induced activation of DNAzyme for highly sensitive colorimetric detection of bleomycin via DNA scission. RSC Advances, 12 (29): (18296-18300). [PMID:35799941] |
41. Hanwen Liu, Ying Liu, Ting Zhou, Penghui Zhou, Jianguo Li, Anping Deng. (2022) Ultrasensitive and Specific Detection of Anticancer Drug 5-Fluorouracil in Blood Samples by a Surface-Enhanced Raman Scattering (SERS)-Based Lateral Flow Immunochromatographic Assay. MOLECULES, 27 (13): (4019). [PMID:35807264] |
42. Kun Fang, Sha Du, Dachuan Shen, Zhipeng Xiong, Ke Jiang, Dapeng Liang, Jianxin Wang, Huizhe Xu, Lulu Hu, Xingyue Zhai, Yuting Jiang, Zhiyu Xia, Chunrui Xie, Di Jin, Wei Cheng, Songshu Meng, Yifei Wang. (2022) SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway. iScience, 25 (104618). [PMID:35800779] |
43. Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang. (2022) Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (12): (6597). [PMID:35743042] |
44. Ting Zhou, Guangzhao He, Changjia Hu, Kang Wu, Ying Liu, Jianguo Li, Anping Deng. (2022) Development of a highly sensitive and specific monoclonal antibody-based ELISA coupled with immuno-affinity extraction for the detection of anticancer drug 5-fluorouracil in blood samples. TALANTA, 249 (123655). [PMID:35696979] |
45. Li Cheng, Fang Wang, Yuanxin Cao, Chaoying Tong, Qisheng Wei, Shuyun Shi, Ying Guo. (2022) Rapid profiling of potential antitumor polymethoxylated flavonoids in natural products by integrating cell biospecific extraction with neutral loss/diagnostic ion filtering-based high-performance liquid chromatography–quadrupole time-of-flight tandem mass spectrometry. PHYTOCHEMICAL ANALYSIS, 33 (6): (895-905). [PMID:35668040] |
46. Hao Guo, Songjie Fan, Jianhua Liu, Yumei Wang. (2022) A dual-pH sensitive drug release system for combinatorial delivery of 5‑fluorouracil and leucovorin calcium in colon cancer therapy. INORGANIC CHEMISTRY COMMUNICATIONS, 141 (109616). [PMID:] |
47. Jieping Zhang, Shaomin Zou, Yijing Zhang, Ziqing Yang, Wencong Wang, Manqi Meng, Junyan Feng, Peng Zhang, Lishi Xiao, Mong-Hong Lee, Lekun Fang. (2022) 3,3′-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer. Metabolites, 12 (5): (410). [PMID:35629914] |
48. Ya-Hui Yu, Zhi-Mei Tang, Cen Xiong, Fei-Fei Wu, Jun-Ren Zhao, Xin-Huai Zhao. (2022) Enhanced Growth Inhibition and Apoptosis Induction in Human Colon Carcinoma HT-29 Cells of Soluble Longan Polysaccharides with a Covalent Chemical Selenylation. Nutrients, 14 (9): (1710). [PMID:35565676] |
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