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G protein-coupled receptors (GPCRs)
Proteinase-activated receptors
F16357 , CAS No.F610267, Agonist of PAR1

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F16357 , CAS No.F610267, Agonist of PAR1

Moligand™

PubChem CID: 19323337

Item Number

F610267

Grouped product items
SKU	Size	Availability	Price	Qty
F610267-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$244.90
F610267-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90

View related series

PAR1 Agonist

Basic Description

Synonyms	Compound 39;Example 1 in WO2007147824
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of PAR1

Associated Targets(Human)

F2R Tclin Proteinase-activated receptor 1 (1 Activities)

Discover Target: F2R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

F2R Tclin Proteinase-activated receptor 1 (1799 Activities)

Discover Target: F2R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

F2RL3 Tchem Proteinase activated receptor 4 (1491 Activities)

Discover Target: F2RL3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

F2RL1 Tchem Proteinase-activated receptor 2 (703 Activities)

Discover Target: F2RL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHO (4503 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(E)-3-(2-chlorophenyl)-1-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]prop-2-en-1-one
INCHI	InChI=1S/C20H20ClFN2O/c21-19-4-2-1-3-17(19)7-10-20(25)24-13-11-23(12-14-24)15-16-5-8-18(22)9-6-16/h1-10H,11-15H2/b10-7+
InChi Key	RMDYFILMTQCLCQ-JXMROGBWSA-N
Canonical SMILES	Fc1ccc(cc1)CN1CCN(CC1)C(=O)/C=C/c1ccccc1Cl
Isomeric SMILES	C1CN(CCN1CC2=CC=C(C=C2)F)C(=O)/C=C/C3=CC=CC=C3Cl
PubChem CID	19323337

Database links

PubChem CID	19323337
ChEMBL Ligand	CHEMBL559808
GPCRdb Ligand	F16357

Certificates

Certificate of Analysis(COA)

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References

1. Monjotin N, Gillespie J, Farrié M, Le Grand B, Junquero D, Vergnolle N. (2016) F16357, a novel protease-activated receptor 1 antagonist, improves urodynamic parameters in a rat model of interstitial cystitis.. Br J Pharmacol, 173 (14): (2224-36). [PMID:27111354] [10.1021/op500134e]

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