Grouped product items

SKU

Size

Availability

Price

Qty

F129242-5g

In stock

$132.90

F129242-25g

25g

In stock

$598.90

Basic Description

Synonyms	famotidine\|76824-35-6\|Amfamox\|Famodil\|Pepdine\|Pepdul\|Gastropen\|Pepcidine\|Famosan\|Famoxal\|Fluxid\|Gaster\|Lecedil\|Motiax\|Muclox\|Ganor\|Pepcid AC\|Pepcidac\|Pepcid RPD\|PEPCID\|Gastridin\|Antodine\|Apogastine\|Bestidine\|Digervin\|Dispromil\|Quamatel\|Brolin\|Cepal\|Fadul\|
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Selective H 2 receptor antagonist. Shows antiulcer and antioxidant properties. Enhances angiogenesis.
Storage Temp	Protected from light
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST, ANTAGONIST
Mechanism of action	Histamine H2 receptor antagonist
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Famotidine is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions. A histamine HRH2 antagonist with IC50 of 0.6 mM.

Product Properties

ALogP	-0.6

Associated Targets

CTH Tchem Cystathionine gamma-lyase 0 Activities

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CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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DRD2 Tclin D(2) dopamine receptor 0 Activities

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DRD4 Tchem D(4) dopamine receptor 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

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GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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ELANE Tclin Neutrophil elastase 0 Activities

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EGFR Tclin Epidermal growth factor receptor 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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HRH1 Tclin Histamine H1 receptor 0 Activities

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

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SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities

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PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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CA2 Tclin Carbonic anhydrase 2 0 Activities

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CA4 Tclin Carbonic anhydrase 4 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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DRD3 Tclin D(3) dopamine receptor 0 Activities

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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

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HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

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ADORA2A Tclin Adenosine receptor A2a 0 Activities

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ACHE Tclin Acetylcholinesterase 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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HTR7 Tclin 5-hydroxytryptamine receptor 7 0 Activities

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AR Tclin Androgen receptor 0 Activities

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AKR1B1 Tclin Aldose reductase 0 Activities

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ADORA1 Tclin Adenosine receptor A1 0 Activities

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HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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ADORA3 Tchem Adenosine receptor A3 0 Activities

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HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

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HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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EDNRA Tclin Endothelin-1 receptor 0 Activities

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EDNRB Tclin Endothelin receptor type B 0 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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OPRK1 Tclin Kappa-type opioid receptor 0 Activities

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OPRM1 Tclin Mu-type opioid receptor 0 Activities

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NOS2 Tchem Nitric oxide synthase, inducible 0 Activities

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TACR1 Tclin Substance-P receptor 0 Activities

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NOS1 Tchem Nitric oxide synthase, brain 0 Activities

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Names and Identifiers

Pubchem Sid	488195592
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195592
IUPAC Name	3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoylpropanimidamide
INCHI	InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
InChi Key	XUFQPHANEAPEMJ-UHFFFAOYSA-N
Canonical SMILES	C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
Isomeric SMILES	C1=C(N=C(S1)N=C(N)N)CSCC/C(=N/S(=O)(=O)N)/N
WGK Germany	2
RTECS	UA2300000
PubChem CID	5702160
Molecular Weight	337.45
Reaxy-Rn	7226206

Database links

DrugBank Ligand	DB00927
PubChem CID	5702160
CAS Registry No.	76824-35-6
ChEMBL Ligand	CHEMBL902
Wikipedia	Famotidine
ChEBI	CHEBI:4975
BitterDB Ligand	101
PEP	famotidine
DrugCentral Ligand	1129
GPCRdb Ligand	famotidine
PubChem SID	488195592

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot Number	Certificate Type	Date	Item
D2314317	Certificate of Analysis	Mar 15, 2023	F129242
D2314343	Certificate of Analysis	Mar 15, 2023	F129242
D2314416	Certificate of Analysis	Mar 15, 2023	F129242
G1521008	Certificate of Analysis	Feb 03, 2023	F129242

Chemical and Physical Properties

Solubility	DMSO 67 mg/mL (198.54 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM)
Sensitivity	light sensitive
Melt Point(°C)	166-168°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	UA2300000
Reaxy-Rn	7226206

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Famotidine - ≥99%, high purity , Histamine H2 receptor antagonist, CAS No.76824-35-6, Histamine H2 receptor antagonist