Farnesol - mixture of isomers,95%, high purity , CAS No.4602-84-0, Inhibitor of mevalonate kinase

3 Citations
Item Number
F113776
Grouped product items
SKUSizeAvailabilityPrice Qty
F113776-5ml
5ml
In stock
$17.90
F113776-25ml
25ml
In stock
$76.90
F113776-100ml
100ml
In stock
$277.90
F113776-500ml
500ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,246.90

Isoprenoid alcohol. Apoptotic.

View related series
mevalonate kinase Inhibitor

Basic Description

Synonyms(2E, 6E)-3,7,11-trimethyl2,6,10-dodecatrien-1-ol | C01126 | Cyclopropanecarboxylic acid, 3-(2-chloro-2-(4-chlorophenyl)ethenyl)-2,2-dimethyl-, cyano(4-fluoro-3-phenoxyphenyl)methyl ester, trans- | NCGC00255293-01 | 2E,6E-Farnesyl alcohol | 2-trans-S-6-tra
Specifications & PurityMoligand™, ≥95%, mixture of isomers
Biochemical and Physiological MechanismsAn isoprenoid alcohol with chemopreventative and anti-tumor effects in vivo. Inducer of apoptosis.
Shipped InNormal
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of mevalonate kinase
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

MVK Tchem Mevalonate kinase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PANC-1 (6144 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

NA Neuraminidase (1107 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus durans (113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus sobrinus (228 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella typhimurium (15756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Shigella flexneri (1836 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Proteus mirabilis (3894 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Serratia marcescens (3237 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus mutans (2687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus agalactiae (1777 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pyogenes (16140 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cutibacterium acnes (887 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida parapsilosis (8521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Myzus persicae (1112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Stenotrophomonas maltophilia (1743 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leptinotarsa decemlineata (1161 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rhopalosiphum padi (121 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488189833
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488189833
IUPAC Name (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol
INCHI InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3/b14-9+,15-11+
InChi Key CRDAMVZIKSXKFV-YFVJMOTDSA-N
Canonical SMILES CC(=CCCC(=CCCC(=CCO)C)C)C
Isomeric SMILES CC(=CCC/C(=C/CC/C(=C/CO)/C)/C)C
WGK Germany 2
RTECS JR4979000
PubChem CID 445070
Molecular Weight 222.37
Beilstein 1763926
Reaxy-Rn 1763926

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
A2220105Certificate of AnalysisJan 03, 2022 F113776
A2220122Certificate of AnalysisJan 03, 2022 F113776
A2220172Certificate of AnalysisJan 03, 2022 F113776
A2220414Certificate of AnalysisJan 03, 2022 F113776
D2415384Certificate of AnalysisJan 03, 2022 F113776

Chemical and Physical Properties

SolubilityInsoluble in water; Soluble in Alcohol
SensitivityLight Sensitive
Refractive Index1.487-1.492
Flash Point(°F)311 °F
Flash Point(°C)96℃
Boil Point(°C)149°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

WGK Germany 2
RTECS JR4979000
Reaxy-Rn 1763926
Merck Index 3937

Related Documents

Citations of This Product

1. Muhammad Noman, Azizullah, Temoor Ahmed, Yizhou Gao, Hui Wang, Xiaohui Xiong, Jiajing Wang, Jiajun Lou, Dayong Li, Fengming Song.  (2023)  Degradation of α-Subunits, Doa1 and Doa4, are Critical for Growth, Development, Programmed Cell Death Events, Stress Responses, and Pathogenicity in the Watermelon Fusarium Wilt Fungus Fusarium oxysporum f. sp. niveum.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (30): (11667–11679).  [PMID:37486296]
2. Azizullah, Muhammad Noman, Yizhou Gao, Hui Wang, Xiaohui Xiong, Jiajing Wang, Dayong Li, Fengming Song.  (2023)  The SUMOylation Pathway Components Are Required for Vegetative Growth, Asexual Development, Cytotoxic Responses, and Programmed Cell Death Events in Fusarium oxysporum f. sp. niveum.  Journal of Fungi,  (1): (94).  [PMID:36675915]
3. Yaling Huang, Junwen Wan, Min Sun, Tao Feng, Qian Liu, Shiqing Song, Xiaoming Zhang, Chi-Tang Ho.  (2023)  Flavor profile disclosure of Chinese steamed breads (CSBs) by sensomics approach.  Food Bioscience,  51  (102198).  [PMID:]

References

1. Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, Noonan DJ, Burka LT, McMorris T, Lamph WW, Evans RM, Weinberger C.  (1995)  Identification of a nuclear receptor that is activated by farnesol metabolites..  Cell,  81  (5): (687-93).  [PMID:7774010]
2. J B Roullet,H Xue,J Chapman,P McDougal,C M Roullet,D A McCarron.  (1996-05-15)  Farnesyl analogues inhibit vasoconstriction in animal and human arteries..  The Journal of clinical investigation,  97  ((10)): (2384-2390).  [PMID:8636420]
3. Y Saisho,A Morimoto,T Umeda.  (1997-11-05)  Determination of farnesyl pyrophosphate in dog and human plasma by high-performance liquid chromatography with fluorescence detection..  Analytical biochemistry,  252  ((1)): (89-95).  [PMID:9324945]
4. D A Andres,D C Crick,B S Finlin,C J Waechter.  (1999-07-10)  Rapid identification of cysteine-linked isoprenyl groups by metabolic labeling with [3H]farnesol and [3H]geranylgeraniol..  Methods in molecular biology (Clifton, N.J.),  116  (107-123).  [PMID:10399149]
5. K Hanley,L G Kömüves,D C Ng,K Schoonjans,S S He,P Lau,D D Bikle,M L Williams,P M Elias,J Auwerx,K R Feingold.  (2001-02-07)  Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha..  The Journal of biological chemistry,  275  ((15)): (11484-11491).  [PMID:10753967]
6. K Hanley,L Wood,D C Ng,S S He,P Lau,A Moser,P M Elias,D D Bikle,M L Williams,K R Feingold.  (2001-03-20)  Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D..  Journal of lipid research,  42  ((3)): (390-398).  [PMID:11254751]
7. E Fayard,K Schoonjans,J Auwerx.  (2001-03-27)  Xol INXS: role of the liver X and the farnesol X receptors..  Current opinion in lipidology,  12  ((2)): (113-120).  [PMID:11264982]
8. Andrea E DeBarber,Lisa A Bleyle,Jean-Baptiste O Roullet,Dennis R Koop.  (2004-05-26)  Omega-hydroxylation of farnesol by mammalian cytochromes p450..  Biochimica et biophysica acta,  1682  ((1-3)): (18-27).  [PMID:15158752]
9. Thomas L Horn,Lina Long,Michael J Cwik,Robert L Morrissey,Izet M Kapetanovic,David L McCormick.  (2005-04-21)  Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol..  Chemico-biological interactions,  152  ((2-3)): (79-99).  [PMID:15840382]
10. Tristan Rossignol,Mary E Logue,Kieran Reynolds,Muriel Grenon,Noel F Lowndes,Geraldine Butler.  (2007-08-09)  Transcriptional response of Candida parapsilosis following exposure to farnesol..  Antimicrobial agents and chemotherapy,  51  ((7)): (2304-2312).  [PMID:17684006]
11. Roman Shchepin,Dhammika H M L P Navarathna,Raluca Dumitru,Shane Lippold,Kenneth W Nickerson,Patrick H Dussault.  (2007-11-27)  Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans..  Bioorganic & medicinal chemistry,  16  ((4)): (1842-1848).  [PMID:18037299]
12. Nobuwa Aoki,Mai Muko,Emi Ohta,Shinji Ohta.  (2008-06-19)  C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity..  Journal of natural products,  71  ((7)): (1308-1310).  [PMID:18558745]
13. A Lapczynski,S P Bhatia,C S Letizia,A M Api.  (2008-07-22)  Fragrance material review on farnesol..  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,  46 Suppl 11  (S149-S156).  [PMID:18640198]
14. Jiaxi Ding,Dechen Jiang,Michael Kurczy,Jennifer Nalepka,Brian Dudley,Erin I Merkel,Forbes D Porter,Andrew G Ewing,Nicholas Winograd,James Burgess,Kathleen Molyneaux.  (2009-01-02)  Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse..  BMC developmental biology,  (120-120).  [PMID:19117526]
15. Louise A Knight,Christian M Kurbacher,Sharon Glaysher,Augusta Fernando,Ralf Reichelt,Susanne Dexel,Uwe Reinhold,Ian A Cree.  (2009-01-30)  Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay..  BMC cancer,  (38-38).  [PMID:19175937]
16. Mark E Shirtliff,Bastiaan P Krom,Roelien A M Meijering,Brian M Peters,Jingsong Zhu,Mark A Scheper,Megan L Harris,Mary Ann Jabra-Rizk.  (2009-04-15)  Farnesol-induced apoptosis in Candida albicans..  Antimicrobial agents and chemotherapy,  53  ((6)): (2392-2401).  [PMID:19364863]
17. Fu Chen,Xin-Ming Liu,Kelly C Rice,Xue Li,Fang Yu,Richard A Reinhardt,Kenneth W Bayles,Dong Wang.  (2009-08-26)  Tooth-binding micelles for dental caries prevention..  Antimicrobial agents and chemotherapy,  53  ((11)): (4898-4902).  [PMID:19704121]
18. Melanie L Langford,Sahar Hasim,Kenneth W Nickerson,Audrey L Atkin.  (2009-11-26)  Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions..  Antimicrobial agents and chemotherapy,  54  ((2)): (940-942).  [PMID:19933803]
19. Melanie L Langford,Audrey L Atkin,Kenneth W Nickerson.  (2009-12-10)  Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans..  Future microbiology,  ((10)): (1353-1362).  [PMID:19995193]
20. Ulrike Grienke,Michaela Schmidtke,Johannes Kirchmair,Kathrin Pfarr,Peter Wutzler,Ralf Dürrwald,Gerhard Wolber,Klaus R Liedl,Hermann Stuppner,Judith M Rollinger.  (2009-12-18)  Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai..  Journal of medicinal chemistry,  53  ((2)): (778-786).  [PMID:20014777]
21. Sarah Gilpin,Howard Maibach.  (2010-09-23)  Allergic contact dermatitis caused by farnesol: clinical relevance..  Cutaneous and ocular toxicology,  29  ((4)): (278-287).  [PMID:20858058]
22. Gérald E Piérard,Trinh Hermanns-Lê,Philippe Delvenne,Claudine Piérard-Franchimont.  (2012-05-10)  Miconazole, a pharmacological barrier to skin fungal infections..  Expert opinion on pharmacotherapy,  13  ((8)): (1187-1194).  [PMID:22568580]
23. Rossana de Aguiar Cordeiro,George Cândido Nogueira,Raimunda Sâmia Nogueira Brilhante,Carlos Eduardo Cordeiro Teixeira,Charles Ielpo Mourão,Débora de Souza Collares Maia Castelo-Branco,Manoel de Araújo Neto Paiva,Joyce Fonteles Ribeiro,André Jalles Monteiro,José Júlio Costa Sidrim,Marcos Fábio Gadelha Rocha.  (2012-05-15)  Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes..  Veterinary microbiology,  159  ((3-4)): (375-380).  [PMID:22580194]
24. Nuno Cerca,Fernanda Gomes,Sofia Pereira,Pilar Teixeira,Rosário Oliveira.  (2012-05-18)  Confocal laser scanning microscopy analysis of S. epidermidis biofilms exposed to farnesol, vancomycin and rifampicin..  BMC research notes,  (244-244).  [PMID:22591918]
25. Marianna Agassandian,Bill B Chen,Roopa Pulijala,Leah Kaercher,Jennifer R Glasser,Rama K Mallampalli.  (2012-05-25)  Calcium-calmodulin kinase I cooperatively regulates nucleocytoplasmic shuttling of CCTα by accessing a nuclear export signal..  Molecular biology of the cell,  23  ((14)): (2755-2769).  [PMID:22621903]
26. Dirk Wartenberg,Martin Vödisch,Olaf Kniemeyer,Daniela Albrecht-Eckardt,Kirstin Scherlach,Robert Winkler,Mirko Weide,Axel A Brakhage.  (2012-05-29)  Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin..  Journal of proteomics,  75  ((13)): (4038-4049).  [PMID:22634043]
27. Najla Nasr,Susan Maddocks,Stuart G Turville,Andrew N Harman,Natalie Woolger,Karla J Helbig,John Wilkinson,Chris R Bye,Thomas K Wright,Dharshini Rambukwelle,Heather Donaghy,Michael R Beard,Anthony L Cunningham.  (2012-06-09)  HIV-1 infection of human macrophages directly induces viperin which inhibits viral production..  Blood,  120  ((4)): (778-788).  [PMID:22677126]
28. Adam Mor,Elizabeta Aizman,Yoel Kloog.  (2012-06-13)  Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production..  Inflammation,  35  ((5)): (1706-1714).  [PMID:22688643]
29. Yehua Jin,Fayang G Qiu.  (2012-06-20)  A convergent stereocontrolled total synthesis of (-)-terpestacin..  Organic & biomolecular chemistry,  10  ((28)): (5452-5455).  [PMID:22710980]
30. Rossana A Cordeiro,Carlos E C Teixeira,Raimunda S N Brilhante,Débora S C M Castelo-Branco,Manoel A N Paiva,João J Giffoni Leite,Daniel T Lima,André J Monteiro,José J C Sidrim,Marcos F G Rocha.  (2012-06-21)  Minimum inhibitory concentrations of amphotericin B, azoles and caspofungin against Candida species are reduced by farnesol..  Medical mycology,  51  ((1)): (53-59).  [PMID:22712455]
31. Efrat Mashiach-Farkash,Roni Rak,Galit Elad-Sfadia,Roni Haklai,Shmuel Carmeli,Yoel Kloog,Haim J Wolfson.  (2012-07-11)  Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton..  Oncotarget,  ((6)): (629-639).  [PMID:22776759]
32. Man-Shun Fu,Luisa De Sordi,Fritz A Mühlschlegel.  (2012-08-11)  Functional characterization of the small heat shock protein Hsp12p from Candida albicans..  PloS one,  ((8)): (e42894-e42894).  [PMID:22880130]
33. Allia K Lindsay,Aurélie Deveau,Amy E Piispanen,Deborah A Hogan.  (2012-08-14)  Farnesol and cyclic AMP signaling effects on the hypha-to-yeast transition in Candida albicans..  Eukaryotic cell,  11  ((10)): (1219-1225).  [PMID:22886999]
34. Megan L Falsetta,Marlise I Klein,José A Lemos,Bruno B Silva,Senyo Agidi,Kathy K Scott-Anne,Hyun Koo.  (2012-09-19)  Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo..  Antimicrobial agents and chemotherapy,  56  ((12)): (6201-6211).  [PMID:22985885]
35. Amir Kraitzer,David Alperstein,Yoel Kloog,Meital Zilberman.  (2012-10-16)  Mechanisms of antiproliferative drug release from bioresorbable porous structures..  Journal of biomedical materials research. Part A,  101  ((5)): (1302-1310).  [PMID:23065767]
36. Phillip A Lichtor,Scott J Miller.  (2012-11-24)  Combinatorial evolution of site- and enantioselective catalysts for polyene epoxidation..  Nature chemistry,  ((12)): (990-995).  [PMID:23174978]
37. Luca Mologni,Stefania Brussolo,Monica Ceccon,Carlo Gambacorti-Passerini.  (2012-12-12)  Synergistic effects of combined Wnt/KRAS inhibition in colorectal cancer cells..  PloS one,  ((12)): (e51449-e51449).  [PMID:23227266]
38. Flávio Rodrigues Ferreira Alves,Marlei Gomes Silva,Isabela Neves Rôças,José Freitas Siqueira.  (2013-01-12)  Biofilm biomass disruption by natural substances with potential for endodontic use..  Brazilian oral research,  27  ((1)): (20-25).  [PMID:23306623]
39. N Charette,C De Saeger,Y Horsmans,I Leclercq,P Stärkel.  (2013-01-26)  Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms..  Cell death & disease,  (e471-e471).  [PMID:23348585]
40. Nuno Cerca,Fernanda Gomes,Joana C Bento,Angela França,Joana Rolo,Maria Miragaia,Pilar Teixeira,Rosário Oliveira.  (2013-04-04)  Farnesol induces cell detachment from established S. epidermidis biofilms..  The Journal of antibiotics,  66  ((5)): (255-258).  [PMID:23549353]
41. Melanie L Langford,Jessica C Hargarten,Krista D Patefield,Elizabeth Marta,Jill R Blankenship,Saranna Fanning,Kenneth W Nickerson,Audrey L Atkin.  (2013-07-23)  Candida albicans Czf1 and Efg1 coordinate the response to farnesol during quorum sensing, white-opaque thermal dimorphism, and cell death..  Eukaryotic cell,  12  ((9)): (1281-1292).  [PMID:23873867]
42. Fredrick Onono,Thangaiah Subramanian,Manjula Sunkara,Karunai Leela Subramanian,H Peter Spielmann,Andrew J Morris.  (2013-08-03)  Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway..  The Journal of biological chemistry,  288  ((38)): (27444-27455).  [PMID:23908355]
43. Jaeho Ha,Yiru Wang,Hyejin Jang,Homoon Seog,Xi Chen.  (2013-09-05)  Determination of E,E-farnesol in Makgeolli (rice wine) using dynamic headspace sampling and stir bar sorptive extraction coupled with gas chromatography-mass spectrometry..  Food chemistry,  142  (79-86).  [PMID:24001815]
44. Ayman Sabra,Jean-Jacques Bessoule,Vessela Atanasova-Penichon,Thierry Noël,Karine Dementhon.  (2013-11-06)  Host-pathogen interaction and signaling molecule secretion are modified in the dpp3 knockout mutant of Candida lusitaniae..  Infection and immunity,  82  ((1)): (413-422).  [PMID:24191303]
45. Xiaolan Zhang,Yixian Huang,Song Li.  (2013-12-18)  Nanomicellar carriers for targeted delivery of anticancer agents..  Therapeutic delivery,  ((1)): (53-68).  [PMID:24341817]
46. Takamitsu Matsuzawa,Tatsuyoshi Kawamura,Youichi Ogawa,Kenji Maeda,Hirotomo Nakata,Kohji Moriishi,Yoshio Koyanagi,Hiroyuki Gatanaga,Shinji Shimada,Hiroaki Mitsuya.  (2014-01-05)  EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium..  The Journal of investigative dermatology,  134  ((4)): (1158-1161).  [PMID:24384694]
47. S Zafar,D E Coates,M P Cullinan,B K Drummond,T Milne,G J Seymour.  (2014-04-26)  Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts..  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,  43  ((9)): (711-721).  [PMID:24762323]
48. Stephanie M J Fliedner,Tobias Engel,Nikoletta K Lendvai,Uma Shankavaram,Svenja Nölting,Robert Wesley,Abdel G Elkahloun,Hendrik Ungefroren,Angela Oldoerp,Gary Lampert,Hendrik Lehnert,Henri Timmers,Karel Pacak.  (2014-05-23)  Anti-cancer potential of MAPK pathway inhibition in paragangliomas-effect of different statins on mouse pheochromocytoma cells..  PloS one,  ((5)): (e97712-e97712).  [PMID:24846270]
49. Xiaoyun Wang,Youzhi Wang,Yuguang Zhou,Xinli Wei.  (2014-06-05)  Farnesol induces apoptosis-like cell death in the pathogenic fungus Aspergillus flavus..  Mycologia,  106  ((5)): (881-888).  [PMID:24895430]
50. Aspasia Katragkou,Matthew McCarthy,Elizabeth L Alexander,Charalampos Antachopoulos,Joseph Meletiadis,Mary Ann Jabra-Rizk,Vidmantas Petraitis,Emmanuel Roilides,Thomas J Walsh.  (2014-10-08)  In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilms..  The Journal of antimicrobial chemotherapy,  70  ((2)): (470-478).  [PMID:25288679]
51. Raimunda Sâmia Nogueira Brilhante,Natalya Fechine Silva,Francisca Jakelyne de Farias Marques,Débora de Souza Collares Maia Castelo-Branco,Rita Amanda Chaves de Lima,Angela Donato Maia Malaquias,Erica Pacheco Caetano,Giovanna Riello Barbosa,Zoilo Pires de Camargo,Anderson Messias Rodrigues,André Jalles Monteiro,Tereza de Jesus Pinheiro Gomes Bandeira,Rossana de Aguiar Cordeiro,José Júlio Costa Sidrim,José Luciano Bezerra Moreira,Marcos Fábio Gadelha Rocha.  (2014-12-30)  In vitro inhibitory activity of terpenic derivatives against clinical and environmental strains of the Sporothrix schenkii complex..  Medical mycology,  53  ((2)): (93-98).  [PMID:25541558]
52. B N Singh,D K Upreti,B R Singh,G Pandey,S Verma,S Roy,A H Naqvi,A K S Rawat.  (2015-02-04)  Quercetin sensitizes fluconazole-resistant candida albicans to induce apoptotic cell death by modulating quorum sensing..  Antimicrobial agents and chemotherapy,  59  ((4)): (2153-2168).  [PMID:25645848]
53. Raimunda Sâmia Nogueira Brilhante,Rita Amanda Chaves de Lima,Francisca Jakelyne de Farias Marques,Natalya Fechine Silva,Érica Pacheco Caetano,Débora de Souza Collares Maia Castelo-Branco,Tereza de Jesus Pinheiro Gomes Bandeira,José Luciano Bezerra Moreira,Rossana de Aguiar Cordeiro,André Jalles Monteiro,Zoilo Pires de Camargo,José Júlio Costa Sidrim,Marcos Fábio Gadelha Rocha.  (2015-02-07)  Histoplasma capsulatum in planktonic and biofilm forms: in vitro susceptibility to amphotericin B, itraconazole and farnesol..  Journal of medical microbiology,  64  ((Pt 4)): (394-399).  [PMID:25657300]
54. Benjamin Horev,Marlise I Klein,Geelsu Hwang,Yong Li,Dongyeop Kim,Hyun Koo,Danielle S W Benoit.  (2015-02-11)  pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence..  ACS nano,  ((3)): (2390-2404).  [PMID:25661192]
55. Jong Hyun Lee,Chulwon Kim,Sung-Hoon Kim,Gautam Sethi,Kwang Seok Ahn.  (2015-02-24)  Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway..  Cancer letters,  360  ((2)): (280-293).  [PMID:25697480]
56. Marc M Schumacher,Rania Elsabrouty,Joachim Seemann,Youngah Jo,Russell A DeBose-Boyd.  (2015-03-06)  The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase..  eLife,    [PMID:25742604]
57. Delma S Childers,David Kadosh.  (2015-03-27)  Filament condition-specific response elements control the expression of NRG1 and UME6, key transcriptional regulators of morphology and virulence in Candida albicans..  PloS one,  10  ((3)): (e0122775-e0122775).  [PMID:25811669]
58. Alexandre Yukio Saito,Rodrigo Antonio Ceschini Sussmann,Emilia Akemi Kimura,Maria Belen Cassera,Alejandro Miguel Katzin.  (2015-04-17)  Quantification of nerolidol in mouse plasma using gas chromatography-mass spectrometry..  Journal of pharmaceutical and biomedical analysis,  111  (100-103).  [PMID:25880240]
59. Yixiong Chen,Zhibing Duan,Peilin Chen,Yanfang Shang,Chengshu Wang.  (2015-05-30)  The Bax inhibitor MrBI-1 regulates heat tolerance, apoptotic-like cell death, and virulence in Metarhizium robertsii..  Scientific reports,  (10625-10625).  [PMID:26023866]
60. Mohit Tyagi,K P Ravindranathan Kartha.  (2015-06-27)  Synthesis of glycotriazololipids and observations on their self-assembly properties..  Carbohydrate research,  413  (85-92).  [PMID:26114887]
61. Austin B Mogen,Fu Chen,Sang-Joon Ahn,Robert A Burne,Dong Wang,Kelly C Rice.  (2015-07-30)  Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms..  PloS one,  10  ((7)): (e0133886-e0133886).  [PMID:26222384]
62. Martin F Strube-Bloss,Austin Brown,Johannes Spaethe,Thomas Schmitt,Wolfgang Rössler.  (2015-09-05)  Extracting the Behaviorally Relevant Stimulus: Unique Neural Representation of Farnesol, a Component of the Recruitment Pheromone of Bombus terrestris..  PloS one,  10  ((9)): (e0137413-e0137413).  [PMID:26340263]
63. Fan Xie,Pengcheng Li,Jianhua Gong,Jiahong Zhang,Jingping Ma.  (2015-10-27)  The bisphosphonate zoledronic acid effectively targets lung cancer cells by inhibition of protein prenylation..  Biochemical and biophysical research communications,  467  ((4)): (664-669).  [PMID:26498526]
64. Donna S Whitlon,Mary Grover,Sara F Dunne,Sonja Richter,Chi-Hao Luan,Claus-Peter Richter.  (2015-11-03)  Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons..  Scientific reports,  (15960-15960).  [PMID:26521685]
65. Abid Hussain,Muhammad Rizwan-Ul-Haq,Ahmed Mohammed AlJabr,Hassan Al-Ayedh.  (2019-04-28)  Lethality of Sesquiterpenes Reprogramming Red Palm Weevil Detoxification Mechanism for Natural Novel Biopesticide Development..  Molecules (Basel, Switzerland),  24  ((9)):   [PMID:31027367]
66. Kit Kennedy,Simon A Cobbold,Eric Hanssen,Jakob Birnbaum,Natalie J Spillman,Emma McHugh,Hannah Brown,Leann Tilley,Tobias Spielmann,Malcolm J McConville,Stuart A Ralph.  (2019-07-19)  Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking..  PLoS biology,  17  ((7)): (e3000376-e3000376).  [PMID:31318858]
67. Gisselle Moraima Chávez-Andrade,Mário Tanomaru-Filho,Maria Inês Basso Bernardi,Renato de Toledo Leonardo,Gisele Faria,Juliane Maria Guerreiro-Tanomaru.  (2019-07-25)  Antimicrobial and biofilm anti-adhesion activities of silver nanoparticles and farnesol against endodontic microorganisms for possible application in root canal treatment..  Archives of oral biology,  107  (104481-104481).  [PMID:31336203]
68. Seval Erkaya,Nazli Pinar Arslan,Tugba Orak,Nevzat Esim,Mesut Taskin.  (2020-05-26)  Evaluation of tyrosol and farnesol as inducer in pigment production by Monascus purpureus ATCC16365..  Journal of basic microbiology,  60  ((8)): (669-678).  [PMID:32449551]
69. D C Crick,D A Andres,C J Waechter.  (1997-08-28)  Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation..  Biochemical and biophysical research communications,  237  ((3)): (483-487).  [PMID:9299388]
70. Adam G Staines,Pavel Sindelar,Michael W H Coughtrie,Brian Burchell.  (2004-08-24)  Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1..  The Biochemical journal,  384  ((Pt 3)): (637-645).  [PMID:15320866]
71. Kenneth W Nickerson,Audrey L Atkin,Jacob M Hornby.  (2006-06-06)  Quorum sensing in dimorphic fungi: farnesol and beyond..  Applied and environmental microbiology,  72  ((6)): (3805-3813).  [PMID:16751484]
72. Said Saidi,Cyril Luitaud,Mahmoud Rouabhia.  (2006-07-18)  In vitro synergistic effect of farnesol and human gingival cells against Candida albicans..  Yeast (Chichester, England),  23  ((9)): (673-687).  [PMID:16845684]
73. Tamaki Cho,Toshihiro Aoyama,Mika Toyoda,Hironobu Nakayama,Hiroji Chibana,Hidenori Kaminishi,Richard A Calderone.  (2008-11-13)  [Farnesol as a quorum-sensing molecule in Candida albicans]..  Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology,  49  ((4)): (281-286).  [PMID:19001754]
74. Joung Hyuck Joo,Anton M Jetten.  (2009-06-13)  Molecular mechanisms involved in farnesol-induced apoptosis..  Cancer letters,  287  ((2)): (123-135).  [PMID:19520495]
75. Taísa Magnani Dinamarco,Maria Helena S Goldman,Gustavo Henrique Goldman.  (2011-09-23)  Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans..  Biochemical Society transactions,  39  ((5)): (1544-1548).  [PMID:21936849]
76. A Berrocal,J Navarrete,C Oviedo,K W Nickerson.  (2012-04-24)  Quorum sensing activity in Ophiostoma ulmi: effects of fusel oils and branched chain amino acids on yeast-mycelial dimorphism..  Journal of applied microbiology,  113  ((1)): (126-134).  [PMID:22519968]
77. Daniel Laheru,Preeti Shah,N V Rajeshkumar,Florencia McAllister,Gretchen Taylor,Howard Goldsweig,Dung T Le,Ross Donehower,Antonio Jimeno,Sheila Linden,Ming Zhao,Dongweon Song,Michelle A Rudek,Manuel Hidalgo.  (2012-05-02)  Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer..  Investigational new drugs,  30  ((6)): (2391-2399).  [PMID:22547163]
78. Ting-Li Han,Richard D Cannon,Silas G Villas-Bôas.  (2012-08-01)  The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions..  FEMS yeast research,  12  ((8)): (879-889).  [PMID:22846172]
79. Wenqiang Chang,Ying Li,Li Zhang,Aixia Cheng,Hongxiang Lou.  (2012-08-01)  Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production..  PloS one,  ((7)): (e41624-e41624).  [PMID:22848547]
80. Milena Cotoras,Paulo Castro,Herman Vivanco,Ricardo Melo,Leonora Mendoza.  (2012-09-11)  Farnesol induces apoptosis-like phenotype in the phytopathogenic fungus Botrytis cinerea..  Mycologia,  105  ((1)): (28-33).  [PMID:22962358]
81. Eran Schmukler,Efrat Grinboim,Sari Schokoroy,Adva Amir,Eya Wolfson,Yoel Kloog,Ronit Pinkas-Kramarski.  (2013-02-02)  Ras inhibition enhances autophagy, which partially protects cells from death..  Oncotarget,  ((1)): (145-155).  [PMID:23370967]
82. Rina Neeman,Shirley Abramovitch,Efrat Sharvit,Galit Elad-Sfadia,Roni Haklai,Yoel Kloog,Shimon Reif.  (2014-06-20)  Vitamin D and S-farnesylthiosalicylic acid have a synergistic effect on hepatic stellate cells proliferation..  Digestive diseases and sciences,  59  ((10)): (2462-2469).  [PMID:24942325]
83. Sangkyu Park,Ae Ran Park,Soonduk Im,Yun-Jeong Han,Sungbeom Lee,Kyoungwhan Back,Jeong-Il Kim,Young Soon Kim.  (2014-10-07)  Developmentally regulated sesquiterpene production confers resistance to Colletotrichum gloeosporioides in ripe pepper fruits..  PloS one,  ((10)): (e109453-e109453).  [PMID:25286411]
84. Daniel B Raudabaugh,Andrew N Miller.  (2015-07-15)  Effect of Trans, Trans-Farnesol on Pseudogymnoascus destructans and Several Closely Related Species..  Mycopathologia,  180  ((5-6)): (325-332).  [PMID:26162644]
85. Ke-Feng Wang,Chen Guo,Fang Ju,Nadia A Samak,Guo-Qiang Zhuang,Chun-Zhao Liu.  (2018-10-14)  Farnesol-induced hyperbranched morphology with short hyphae and bulbous tips of Coriolus versicolor..  Scientific reports,  ((1)): (15213-15213).  [PMID:30315269]
86. Muhammad Noman, Azizullah, Temoor Ahmed, Yizhou Gao, Hui Wang, Xiaohui Xiong, Jiajing Wang, Jiajun Lou, Dayong Li, Fengming Song.  (2023)  Degradation of α-Subunits, Doa1 and Doa4, are Critical for Growth, Development, Programmed Cell Death Events, Stress Responses, and Pathogenicity in the Watermelon Fusarium Wilt Fungus Fusarium oxysporum f. sp. niveum.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (30): (11667–11679).  [PMID:37486296]
87. Azizullah, Muhammad Noman, Yizhou Gao, Hui Wang, Xiaohui Xiong, Jiajing Wang, Dayong Li, Fengming Song.  (2023)  The SUMOylation Pathway Components Are Required for Vegetative Growth, Asexual Development, Cytotoxic Responses, and Programmed Cell Death Events in Fusarium oxysporum f. sp. niveum.  Journal of Fungi,  (1): (94).  [PMID:36675915]
88. Yaling Huang, Junwen Wan, Min Sun, Tao Feng, Qian Liu, Shiqing Song, Xiaoming Zhang, Chi-Tang Ho.  (2023)  Flavor profile disclosure of Chinese steamed breads (CSBs) by sensomics approach.  Food Bioscience,  51  (102198).  [PMID:]

Solution Calculators