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SKU | Size | Availability | Price | Qty |
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F275751-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $47.90 | |
F275751-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $199.90 |
Potent, selective ATP-competitve CDK4 inhibitor
Synonyms | Fascaplysin | Fascaplysine | 114719-57-2 | Fascaplysin chloride | CHEMBL258765 | Fascaplisine | NSC622398 | NSC-622398 | Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride | 3-aza-13-azoniapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,11,14,16 |
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Biochemical and Physiological Mechanisms | Potent, selective ATP-competitive CDK4 inhibitor (IC 50 = 350 nM). Suppresses VEGF expression and inhibits endothelial cell proliferation. Induces apoptosis and cytotoxic autophagy in vitro . |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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IUPAC Name | 3-aza-13-azoniapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,11,14,16,18-nonaen-20-one;chloride |
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INCHI | InChI=1S/C18H10N2O.ClH/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20;/h1-10H;1H |
InChi Key | PWUOOJVYZQILBG-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C3=C(N2)C4=[N+](C=C3)C5=CC=CC=C5C4=O.[Cl-] |
Isomeric SMILES | C1=CC=C2C(=C1)C3=C(N2)C4=[N+](C=C3)C5=CC=CC=C5C4=O.[Cl-] |
PubChem CID | 73292 |
Molecular Weight | 271.33545 |
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