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FASUDIL - ≥98% (HPLC), high purity , Rho-associated protein kinase inhibitor, CAS No.103745-39-7, Rho-associated protein kinase inhibitor

Moligand™
≥98%(HPLC)

CAS#: 103745-39-7
Formula: C₁₄H₁₇N₃O₂S
Molecular Weight: 291.37
MDL number: MFCD00866182
PubChem CID: 3547

Item Number

F134784

Grouped product items
SKU	Size	Availability	Price
F134784-250mg	250mg	In stock	$15.90
F134784-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$41.90
F134784-5g	5g	In stock	$162.90

ROCK2 inhibitor

View related series

Rho associated coiled-coil containing protein kinase 1 Inhibitor Rho associated coiled-coil containing protein kinase 2 Inhibitor

Basic Description

Synonyms	Fasudil\|103745-39-7\|ha-1077\|HA 1077\|AT 877\|HA1077\|Fasudil [INN]\|Fasudilum\|1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-\|AT-877\|1-(5-Isoquinolinesulfonyl)homopiperazine\|5-(1,4-diazepan-1-ylsulfonyl)isoquinoline\|5-(1,4-diazepane-1-sulfonyl)isoqui
Specifications & Purity	≥98%(HPLC)
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Rho-associated protein kinase inhibitor

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 1 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ROCK2 Tclin Rho-associated protein kinase 2 1 Activities

Discover Target: ROCK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ROCK1 Tclin Rho-associated protein kinase 1 1 Activities

Discover Target: ROCK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
INCHI	InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2
InChi Key	NGOGFTYYXHNFQH-UHFFFAOYSA-N
Canonical SMILES	C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
Isomeric SMILES	C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
PubChem CID	3547
Molecular Weight	291.37

CAS Registry No.

Wikipedia

PubChem CID

ChEMBL Ligand

RCSB PDB Ligand

PEP

DrugCentral Ligand

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
E2422096	Certificate of Analysis	May 11, 2024	F134784
H2206724	Certificate of Analysis	May 11, 2024	F134784
H2206584	Certificate of Analysis	May 09, 2024	F134784
B2429020	Certificate of Analysis	Jun 15, 2022	F134784
H2206723	Certificate of Analysis	Jun 15, 2022	F134784
H2303098	Certificate of Analysis	Jun 15, 2022	F134784
L2307083	Certificate of Analysis	Jun 15, 2022	F134784

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Huentelman MJ, Stephan DA, Talboom J, Corneveaux JJ, Reiman DM, Gerber JD, Barnes CA, Alexander GE, Reiman EM, Bimonte-Nelson HA. (2009) Peripheral delivery of a ROCK inhibitor improves learning and working memory.. Behav Neurosci, 123 (1): (218-23). [PMID:19170447]
2. Doggrell SA. (2005) Rho-kinase inhibitors show promise in pulmonary hypertension.. Expert Opin Investig Drugs, 14 (9): (1157-9). [PMID:16144499]
3. Asano T, Suzuki T, Tsuchiya M, Satoh S, Ikegaki I, Shibuya M, Suzuki Y, Hidaka H. (1989) Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase.. Br J Pharmacol, 98 (4): (1091-100). [PMID:2611484]
4. Shibuya M, Suzuki Y. (1993) [Treatment of cerebral vasospasm by a protein kinase inhibitor AT 877].. No To Shinkei, 45 (9): (819-24). [PMID:8217408]

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