Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50= 10.7μM). Suppress MMP-2 expression and induce apoptosis in glioblastoma cellsin vivo. Ca2+antagonist and vasodilator. Also inhibits proliferation of vascular s
Storage Temp
Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1. A selective ROCK inhibitor
Associated Targets(Human)
CCR2TchemC-C chemokine receptor type 2 (5628 Activities)
A1710017