Grouped product items

SKU

Size

Availability

Price

Qty

F303252-100mg

100mg

In stock

$147.90

F303252-250mg

250mg

In stock

$333.90

F303252-1g

In stock

$1,198.90

F303252-5g

In stock

$5,394.90

F303252-25g

25g

In stock

$24,275.90

F303252-100g

100g

In stock

$87,392.90

Basic Description

Synonyms	BBL104098 \| AKOS015995178 \| EN300-1601539 \| favipira \| MFCD12032148 \| Fapilavir \| GTPL11139 \| HY-14768 \| SY110833 \| EW5GL2X7E0 \| NCGC00373041-03 \| DTXSID60948878 \| SW218108-2 \| T 705 \| Z1255381648 \| PB42412 \| ZCGNOVWYSGBHAU-UHFFFAOYSA-N \| AKOS005166863 \|
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Viral RNA polymerase inhibitor; exhibits no effects on mammalian RNA polymerase. Prodrug that is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5'-triphosphate (RTP). Reduces infection rate of SARS-CoV-2 in Vero E6 ce
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	RNA-directed RNA polymerase inhibitor

Product Properties

ALogP	-0.6

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PGR Tclin Progesterone receptor (8562 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

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TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)

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PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

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ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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HRH3 Tclin Histamine H3 receptor (10389 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterovirus C (520 Activities)

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Influenza B virus (2113 Activities)

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Rift Valley fever virus (132 Activities)

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Tacaribe virus (95 Activities)

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Mus musculus (284745 Activities)

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Yellow fever virus (1530 Activities)

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Influenza A virus (11224 Activities)

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Punta Toro virus (1491 Activities)

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Pichinde virus (130 Activities)

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Enterovirus (1116 Activities)

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Respiratory syncytial virus (3434 Activities)

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BHK-21 (725 Activities)

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MDCK (10148 Activities)

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Vero (26788 Activities)

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Syrian golden hamster (1610 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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dengue virus type 2 (2400 Activities)

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H2N2 subtype (35 Activities)

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Influenza C virus (1 Activities)

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La Crosse virus (130 Activities)

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Sandfly fever Naples virus (3 Activities)

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Chikungunya virus (1339 Activities)

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Marburgvirus (118 Activities)

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Zika virus (1028 Activities)

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SARS-CoV-2 (38078 Activities)

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SARS-CoV (424 Activities)

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Vero C1008 (1716 Activities)

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Ebolavirus (617 Activities)

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Zaire ebolavirus (77 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5-fluoro-2-oxo-1H-pyrazine-3-carboxamide
INCHI	InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)
InChi Key	ZCGNOVWYSGBHAU-UHFFFAOYSA-N
Canonical SMILES	C1=C(N=C(C(=O)N1)C(=O)N)F
Isomeric SMILES	C1=C(N=C(C(=O)N1)C(=O)N)F
PubChem CID	492405
Molecular Weight	157.1

Database links

PubChem CID	492405
CAS Registry No.	259793-96-9
ChEMBL Ligand	CHEMBL221722
DrugBank Ligand	DB12466
DrugCentral Ligand	4887

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
C2204492	Certificate of Analysis	Dec 05, 2024	F303252
C2204494	Certificate of Analysis	Dec 05, 2024	F303252
C2205031	Certificate of Analysis	Dec 05, 2024	F303252
C2205033	Certificate of Analysis	Dec 05, 2024	F303252
C2205034	Certificate of Analysis	Dec 05, 2024	F303252
C2205035	Certificate of Analysis	Dec 05, 2024	F303252
F2418036	Certificate of Analysis	Jan 19, 2022	F303252

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 15.71, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.14, Max Conc. mM: 20
Sensitivity	Air Sensitive,Heat Sensitive
Melt Point(°C)	192 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Dai Tianming, Wang Min, Wang Pengzhen, Dai Libing, Dai Renke, Meng Qingqi. (2021) Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora. PHARMAZIE, 76 (5): (195-201). [PMID:33964992] [10.1691/ph.2021.01005]

References

1. Furuta Y, Takahashi K, Fukuda Y, Kuno M, Kamiyama T, Kozaki K, Nomura N, Egawa H, Minami S, Watanabe Y et al.. (2002) In vitro and in vivo activities of anti-influenza virus compound T-705.. Antimicrob Agents Chemother, 46 (4): (977-81). [PMID:11897578] [10.1021/op500134e]
2. Furuta Y, Takahashi K, Kuno-Maekawa M, Sangawa H, Uehara S, Kozaki K, Nomura N, Egawa H, Shiraki K. (2005) Mechanism of action of T-705 against influenza virus.. Antimicrob Agents Chemother, 49 (3): (981-6). [PMID:15728892] [10.1021/op500134e]
3. Kiso M, Takahashi K, Sakai-Tagawa Y, Shinya K, Sakabe S, Le QM, Ozawa M, Furuta Y, Kawaoka Y. (2010) T-705 (favipiravir) activity against lethal H5N1 influenza A viruses.. Proc Natl Acad Sci USA, 107 (2): (882-7). [PMID:20080770] [10.1021/op500134e]
4. Safronetz D, Rosenke K, Westover JB, Martellaro C, Okumura A, Furuta Y, Geisbert J, Saturday G, Komeno T, Geisbert TW et al.. (2015) The broad-spectrum antiviral favipiravir protects guinea pigs from lethal Lassa virus infection post-disease onset.. Sci Rep, 5 (13): (14775). [PMID:26456301] [10.1021/op500134e]
5. Nagata T, Lefor AK, Hasegawa M, Ishii M. (2015) Favipiravir: a new medication for the Ebola virus disease pandemic.. Disaster Med Public Health Prep, 9 (1): (79-81). [PMID:25544306] [10.1021/op500134e]
6. Furuta Y, Komeno T, Nakamura T. (2017) Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase.. Proc Jpn Acad, Ser B, Phys Biol Sci, 93 (7): (449-463). [PMID:28769016] [10.1021/op500134e]
7. Delang L, Abdelnabi R, Neyts J. (2018) Favipiravir as a potential countermeasure against neglected and emerging RNA viruses.. Antiviral Res, 153 (13): (85-94). [PMID:29524445] [10.1021/op500134e]
8. Dawes BE, Kalveram B, Ikegami T, Juelich T, Smith JK, Zhang L, Park A, Lee B, Komeno T, Furuta Y et al.. (2018) Favipiravir (T-705) protects against Nipah virus infection in the hamster model.. Sci Rep, 8 (1): (7604). [PMID:29765101] [10.1021/op500134e]
9. Dai Tianming, Wang Min, Wang Pengzhen, Dai Libing, Dai Renke, Meng Qingqi. (2021) Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora. PHARMAZIE, 76 (5): (195-201). [PMID:33964992] [10.1691/ph.2021.01005]

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Favipiravir - ≥99%, high purity , RNA-directed RNA polymerase inhibitor, CAS No.259793-96-9, RNA-directed RNA polymerase inhibitor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator