Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information FB23 FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity. Targets FTO demethylase (Cell-free assay) 60 nM

Associated Targets(Human)

FTO Tchem Alpha-ketoglutarate-dependent dioxygenase FTO (2 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NB-4 (999 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	2-[2,6-dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)anilino]benzoic acid
INCHI	InChI=1S/C18H14Cl2N2O3/c1-9-16(10(2)25-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(23)24/h3-8,21H,1-2H3,(H,23,24)
InChi Key	VUXZATVQMFSUCM-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=NO1)C)C2=CC(=C(C(=C2)Cl)NC3=CC=CC=C3C(=O)O)Cl
Isomeric SMILES	CC1=C(C(=NO1)C)C2=CC(=C(C(=C2)Cl)NC3=CC=CC=C3C(=O)O)Cl
PubChem CID	138393314
Molecular Weight	377.22

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3 results found

Lot Number	Certificate Type	Date	Item
G2226477	Certificate of Analysis	Jun 07, 2022	F413417
G2226478	Certificate of Analysis	Jun 07, 2022	F413417
G2226482	Certificate of Analysis	Jun 07, 2022	F413417

Solubility	Solubility (25°C) In vitro DMSO: 38 mg/mL (100.73 mM); Water: Insoluble; Ethanol: Insoluble;

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SKU	Size	Availability	Price
F413417-5mg	5mg	In stock	$129.90
F413417-25mg	25mg	In stock	$489.90
F413417-100mg	100mg	In stock	$1,764.90