FDI-6 - ≥98%, high purity , CAS No.313380-27-7

Item Number

F414459

• Synonyms: NCGC00099374 | NCGC00099374-01 | AS-57575 | MFCD01416826 | CS-0062893 | 3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide | HMS1798G15 | FDI-6, >=98% (HPLC) | ZATJMMZPGVDUOM-UHFFFAOYSA-N | FOXM1 Inhibitor
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: FDI-6 (NCGC00099374) is an inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) with IC50 of 22.5 μM.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

FDI-6 FDI-6 (NCGC00099374) is an inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) with IC50 of 22.5 μM.

Targets

FOXM1 (Cell-free assay) 22.5 μM

In vitro

FDI-6 (NCGC00099374) is characterized in depth and is shown to bind directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induces concomitant transcriptional down-regulation. Global transcript profiling of MCF-7 cells by RNA-seq shows that FDI-6 specifically down-regulates FOXM1-activated genes with FOXM1 occupancy confirmed by ChIP-seq.

In vivo

Inhibiting FOXM1 with FDI-6 inhibits liver cancer cell growth in vivo.

Cell Research(from reference)

Cell lines：MCF-7 cells 

Concentrations：20 μM, 40 μM 

Incubation Time：6 h