Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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F125720-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $22.90 | |
F125720-250mg | 250mg | In stock | $24.90 | |
F125720-1g | 1g | In stock | $75.90 | |
F125720-5g | 5g | In stock | $242.90 | |
F125720-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $436.90 | |
F125720-25g | 25g | In stock | $981.90 | |
F125720-100g | 100g | In stock | $3,532.90 |
Highly potent, selective, non-competitive, non-purine xanthine oxidase inhibitor
Synonyms | BC164443 | C16H16N2O3S | FEBUXOSTAT (MART.) | Febuxostat [USAN:INN:BAN] | HMS3655C03 | AC-425 | Q417296 | CCG-213303 | DTXSID8048650 | 2-(3-Cyano-4-(2-methylpropoxy)phenyl)-4-methylthiazole-5-carboxylic acid | Febuxostat | FEBUXOSTAT [VANDF] | 2-(3-Cyano- |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Febuxostat is a potent non-purine xanithine oxidase inhibitor. Febuxostat is used in urate lowering therapies (ULTs) for the treatment of gout.Highly potent, selective, non-competitive, non-purine xanthine oxidase inhibitor (K i = 0.6 nM). Inhibits xanthi |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Xanthine dehydrogenase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Description: Febuxostat(TEI 6720;TMX 67 ) is selective xanthine oxidase inhibitor with Ki of 0.6 nM.An inhibitor xanthine oxidase and xanthine dehydrogenase. Febuxostat is a potent, non-purine compound, which inhibits the expression of cytokines/chemokines. It has also been reported to inhibit LPS-induced TNF-α, VCAM-1, MMP9 and MCP-1 expression. |
ALogP | 3.9 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid |
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INCHI | InChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20) |
InChi Key | BQSJTQLCZDPROO-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O |
Isomeric SMILES | CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O |
Alternate CAS | 144060-53-7 |
PubChem CID | 134018 |
NSC Number | 758874 |
MeSH Entry Terms | 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic acid;6720, TEI;febuxostat;TEI 6720;TEI-6720;TEI6720;uloric |
Molecular Weight | 316.38 |
DrugBank Ligand | DB03786 |
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PubChem CID | 134018 |
CAS Registry No. | 144060-53-7 |
ChEMBL Ligand | CHEMBL1164729 |
Wikipedia | Febuxostat |
RCSB PDB Ligand | TEI |
DrugCentral Ligand | 1137 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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I2214496 | Certificate of Analysis | Jun 17, 2024 | F125720 |
I2214503 | Certificate of Analysis | Jun 17, 2024 | F125720 |
I2214504 | Certificate of Analysis | Jun 17, 2024 | F125720 |
I2214505 | Certificate of Analysis | Jun 17, 2024 | F125720 |
I2214506 | Certificate of Analysis | Jun 17, 2024 | F125720 |
I2411202 | Certificate of Analysis | Jun 12, 2024 | F125720 |
I2411203 | Certificate of Analysis | Jun 12, 2024 | F125720 |
K2118487 | Certificate of Analysis | Sep 15, 2023 | F125720 |
K2118489 | Certificate of Analysis | Sep 15, 2023 | F125720 |
K2118636 | Certificate of Analysis | Sep 15, 2023 | F125720 |
F2030080 | Certificate of Analysis | May 06, 2022 | F125720 |
C2010084 | Certificate of Analysis | Jan 27, 2022 | F125720 |
F2316121 | Certificate of Analysis | Sep 16, 2021 | F125720 |
Solubility | DMSO 63 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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Melt Point(°C) | 209 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed |
Precautionary Statements | P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
Merck Index | 3948 |
1. Zean Zhao, Jian Luo, Hui Liao, Fengxin Zheng, Xinhua Chen, Jiajun Luo, Yongjun Chen, Kunlu Zhao, Shuqin Zhang, Jinhong Tian, Ting Wu, Yongmei Li, Lu Li, Yang Yang, Cuiting Lin, Qun Zhang, Yuanxin Tian, Jianxin Pang. (2023) Pharmacological evaluation of a novel skeleton compound isobavachin (4′,7-dihydroxy-8-prenylflavanone) as a hypouricemic agent: Dual actions of URAT1/GLUT9 and xanthine oxidase inhibitory activity. BIOORGANIC CHEMISTRY, 133 (106405). [PMID:36753966] |
2. Yan Liu, Chenggang Han, Tao Lu, Yi Liu, Hao Chen, Can Yang, Yanbei Tu, Yanfang Li. (2021) Investigation of the interaction between Chrysoeriol and xanthine oxidase using computational and in vitro approaches. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 190 (463). [PMID:34506859] |
1. Zean Zhao, Jian Luo, Hui Liao, Fengxin Zheng, Xinhua Chen, Jiajun Luo, Yongjun Chen, Kunlu Zhao, Shuqin Zhang, Jinhong Tian, Ting Wu, Yongmei Li, Lu Li, Yang Yang, Cuiting Lin, Qun Zhang, Yuanxin Tian, Jianxin Pang. (2023) Pharmacological evaluation of a novel skeleton compound isobavachin (4′,7-dihydroxy-8-prenylflavanone) as a hypouricemic agent: Dual actions of URAT1/GLUT9 and xanthine oxidase inhibitory activity. BIOORGANIC CHEMISTRY, 133 (106405). [PMID:36753966] |
2. Yan Liu, Chenggang Han, Tao Lu, Yi Liu, Hao Chen, Can Yang, Yanbei Tu, Yanfang Li. (2021) Investigation of the interaction between Chrysoeriol and xanthine oxidase using computational and in vitro approaches. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 190 (463). [PMID:34506859] |