Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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F119293-1g | 1g | In stock | $9.90 | |
F119293-5g | 5g | In stock | $29.90 | |
F119293-25g | 25g | In stock | $113.90 | |
F119293-100g | 100g | In stock | $406.90 |
Synonyms | fenbendazole | 43210-67-9 | Panacur | Fenbendazol | Phenbendasol | Fenbendazolum | Hoe 881v | Safe-Guard | Methyl 5-(phenylthio)-2-benzimidazolecarbamate | Safe-quard | Panacur aquasol | HOE-881v | 2-(Methoxycarbonylamino)-5-(phenylthio)benzimidazole | Fenbendazole (Panacur) | CCRIS |
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Specifications & Purity | ≥98% |
Shipped In | Normal |
Action Type | BINDING AGENT |
Mechanism of action | Tubulin beta chain |
ALogP | 3.6 |
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Pubchem Sid | 488179760 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179760 |
IUPAC Name | methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate |
INCHI | InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19) |
InChi Key | HDDSHPAODJUKPD-UHFFFAOYSA-N |
Canonical SMILES | COC(=O)NC1=NC2=C(N1)C=C(C=C2)SC3=CC=CC=C3 |
Isomeric SMILES | COC(=O)NC1=NC2=C(N1)C=C(C=C2)SC3=CC=CC=C3 |
PubChem CID | 3334 |
Molecular Weight | 299.35 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F1804084 | Certificate of Analysis | Apr 25, 2022 | F119293 |
F1804083 | Certificate of Analysis | Apr 25, 2022 | F119293 |
G2313102 | Certificate of Analysis | Apr 25, 2022 | F119293 |
D2313567 | Certificate of Analysis | Dec 04, 2021 | F119293 |
G2313095 | Certificate of Analysis | Dec 04, 2021 | F119293 |
L2101085 | Certificate of Analysis | Dec 04, 2021 | F119293 |
Solubility | Insoluble in water |
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Sensitivity | Air Sensitive |
Melt Point(°C) | 233°C |
Pictogram(s) | GHS08, GHS09 |
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Signal | Warning |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H412:Harmful to aquatic life with long lasting effects H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P391:Collect spillage. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
Merck Index | 3960 |
1. Fulin Mao, Weizhong Shi, Hongkun Zhao, Wanxin Li, Abolghasem Jouyban, William E. Acree. (2024) Comprehensive solubility study and inter-molecular interactions on fenbendazole dissolved in some aqueous aprotic and protic co-solvent solutions. JOURNAL OF CHEMICAL THERMODYNAMICS, 191 (107231). [PMID:] |
2. Yi Peng, Jie Pan, Fengting Ou, Wenchao Wang, Haihong Hu, Lu Chen, Su Zeng, Kui Zeng, Lushan Yu. (2022) Fenbendazole and its synthetic analog interfere with HeLa cells’ proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway. CHEMICO-BIOLOGICAL INTERACTIONS, 361 (109983). [PMID:35569513] |
1. Rolf Schiffmann,Alexander Neugebauer,Christian D Klein. (2006-01-20) Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions.. Journal of medicinal chemistry, 49 ((2)): (511-522). [PMID:16420038] |
2. Nassira Mahmoudi,Ramon Garcia-Domenech,Jorge Galvez,Khemais Farhati,Jean-François Franetich,Robert Sauerwein,Laurent Hannoun,Francis Derouin,Martin Danis,Dominique Mazier. (2008-01-24) New active drugs against liver stages of Plasmodium predicted by molecular topology.. Antimicrobial agents and chemotherapy, 52 ((4)): (1215-1220). [PMID:18212104] |
3. Fabien Vincent,Margaret T Nguyen,Daniel E Emerling,Michael G Kelly,Matthew A J Duncton. (2009-10-24) Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.. Bioorganic & medicinal chemistry letters, 19 ((23)): (6793-6796). [PMID:19850474] |
4. Markus A Altmeyer,Aline Marschner,Rolf Schiffmann,Christian D Klein. (2010-07-14) Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors.. Bioorganic & medicinal chemistry letters, 20 ((14)): (4038-4044). [PMID:20621724] |
5. Aileen Adam,Lucy M I Webster,William Mullen,Lukas F Keller,Paul C D Johnson. (2011-01-18) Quantifying fenbendazole and its metabolites in self-medicating wild red grouse Lagopus lagopus scoticus using an HPLC-MS-MS approach.. Veterinary parasitology, 177 ((3-4)): (383-386). [PMID:21236579] |
6. N D Sargison,D J Wilson,C D Penny,D J Bartley. (2011-01-25) Unexpected production loss caused by helminth parasites in weaned beef calves.. The Veterinary record, 167 ((19)): (752-754). [PMID:21257513] |
7. Eugene T Lyons,Sharon C Tolliver,Tetiana A Kuzmina,Sandra S Collins. (2011-04-19) Further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010).. Parasitology research, 109 ((4)): (1193-1197). [PMID:21499750] |
8. Niels C Kyvsgaard,Jenny Lindbom,Line Lundberg Andreasen,Luz Adilia Luna-Olivares,Martin Krarup Nielsen,Jesper Monrad. (2011-05-17) Prevalence of strongyles and efficacy of fenbendazole and ivermectin in working horses in El Sauce, Nicaragua.. Veterinary parasitology, 181 ((2-4)): (248-254). [PMID:21570188] |
9. César Fiel,Maricel Guzmán,Pedro Steffan,Edgardo Rodriguez,Olegario Prieto,Chandra Bhushan. (2011-07-16) The efficacy of trichlorphon and naphthalophos against multiple anthelmintic-resistant nematodes of naturally infected sheep in Argentina.. Parasitology research, 109 Suppl 1 (S139-S148). [PMID:21739383] |
10. Bert E Stromberg,Louis C Gasbarre,Audie Waite,David T Bechtol,Michael S Brown,Nicholas A Robinson,Erik J Olson,Harold Newcomb. (2011-08-09) Cooperia punctata: effect on cattle productivity?. Veterinary parasitology, 183 ((3-4)): (284-291). [PMID:21821358] |
11. Moreno Rossi,Nicoletta Messina,Gaetano Ariti,Francesca Riggio,Stefania Perrucci. (2011-08-13) Symptomatic Capillaria plica infection in a young European cat.. Journal of feline medicine and surgery, 13 ((10)): (793-795). [PMID:21835667] |
12. Jessica Sieg,Jutta Hein,Ariane Jass,Carola Sauter-Louis,Katrin Hartmann,Andrea Fischer. (2012-02-09) Clinical evaluation of therapeutic success in rabbits with suspected encephalitozoonosis.. Veterinary parasitology, 187 ((1-2)): (328-332). [PMID:22309799] |
13. . (2012-03-01) [Reaction to the proteinuria with bolus].. Tijdschrift voor diergeneeskunde, 137 ((1)): (67-67). [PMID:22372068] |
14. Kiyun Park,Inn-Sil Kwak. (2012-05-23) Gene expression of ribosomal protein mRNA in Chironomus riparius: effects of endocrine disruptor chemicals and antibiotics.. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 156 ((2)): (113-120). [PMID:22609975] |
15. Nilambra Dogra,Tapas Mukhopadhyay. (2012-06-30) Impairment of the ubiquitin-proteasome pathway by methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate leads to a potent cytotoxic effect in tumor cells: a novel antiproliferative agent with a potential therapeutic implication.. The Journal of biological chemistry, 287 ((36)): (30625-30640). [PMID:22745125] |
16. M Dabalus Islam,G Haberhauer,M Gerzabek,A Cannavan. (2012-07-26) Liquid chromatography-tandem mass spectrometry method for the determination of anthelmintics in alfalfa plants.. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29 ((11)): (1679-1688). [PMID:22827314] |
17. J P Dubey,M Prowell. (2012-08-29) Ante-mortem diagnosis, diarrhea, oocyst shedding, treatment, isolation, and genetic typing of Toxoplasma gondii associated with clinical toxoplasmosis in a naturally infected cat.. The Journal of parasitology, 99 ((1)): (158-160). [PMID:22924914] |
18. Marie Mény,Anne Schmidt-Küntzel,Laurie L Marker. (2013-01-01) Diagnosis-based treatment of helminths in captive and wild cheetahs (Acinonyx jubatus).. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 43 ((4)): (934-938). [PMID:23272366] |
19. Penny K Patten,Lon J Rich,Karen Zaks,Melissa Blauvelt. (2013-01-03) Cestode infection in 2 dogs: cytologic findings in liver and a mesenteric lymph node.. Veterinary clinical pathology, 42 ((1)): (103-108). [PMID:23278428] |
20. Qiwen Duan,Yanfeng Liu,Sara Rockwell. (2013-02-09) Fenbendazole as a potential anticancer drug.. Anticancer research, 33 ((2)): (355-362). [PMID:23393324] |
21. Anthony A Pilny. (2012-01-01) Excellence in exotics: case report: Encephalitozoon cuniculi-associated phacoclastic uveitis in a dwarf rabbit.. Compendium (Yardley, PA), 34 ((11)): (E5-E5). [PMID:23532791] |
22. Xiao-Lin Hou,Guo Chen,Li Zhu,Ting Yang,Jian Zhao,Lei Wang,Yin-Liang Wu. (2014-06-03) Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962 (20-29). [PMID:24887592] |
23. Vanessa O Ezenwa,Anna E Jolles. (2015-01-13) Epidemiology. Opposite effects of anthelmintic treatment on microbial infection at individual versus population scales.. Science (New York, N.Y.), 347 ((6218)): (175-177). [PMID:25574023] |
24. Christina T K Wales,Frederick R Taylor,Allan T Higa,Harvey A McAllister,Aaron T Jacobs. (2015-03-27) ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells.. Anti-cancer drugs, 26 ((6)): (657-666). [PMID:25811962] |
25. Ivy Chung,Kun Zhou,Courtney Barrows,Jacqueline Banyard,Arianne Wilson,Nathan Rummel,Atsushi Mizokami,Sudipta Basu,Poulomi Sengupta,Badaruddin Shaikh,Shiladitya Sengupta,Diane R Bielenberg,Bruce R Zetter. (2021-03-20) Unbiased Phenotype-Based Screen Identifies Therapeutic Agents Selective for Metastatic Prostate Cancer.. Frontiers in oncology, 10 (594141-594141). [PMID:33738243] |
26. David Villar,Carolyn Cray,Julia Zaias,Norman H Altman. (2007-11-13) Biologic effects of fenbendazole in rats and mice: a review.. Journal of the American Association for Laboratory Animal Science : JAALAS, 46 ((6)): (8-15). [PMID:17994667] |
27. C Chassaing,M Berger,A Heckeroth,T Ilg,M Jaeger,C Kern,K Schmid,M Uphoff. (2008-02-15) Highly water-soluble prodrugs of anthelmintic benzimidazole carbamates: synthesis, pharmacodynamics, and pharmacokinetics.. Journal of medicinal chemistry, 51 ((5)): (1111-1114). [PMID:18271517] |
28. Bettencourt P S Capece,Guillermo L Virkel,Carlos E Lanusse. (2009-01-07) Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: pharmacological implications.. Veterinary journal (London, England : 1997), 181 ((3)): (241-250). [PMID:19124257] |
29. Walter Boyce,Lisa Shender,Laura Schultz,Winston Vickers,Christine Johnson,Michael Ziccardi,Laurel Beckett,Kerry Padgett,Paul Crosbie,Jane Sykes. (2011-04-19) Survival analysis of dogs diagnosed with canine peritoneal larval cestodiasis (Mesocestoides spp.).. Veterinary parasitology, 180 ((3-4)): (256-261). [PMID:21497443] |
30. M K Tanveer,A Kamran,M Abbas,N C Umer,M A Azhar,M Munir. (2011-05-24) Prevalence and chemo-therapeutical investigations of gastrointestinal nematodes in domestic pigeons in Lahore, Pakistan.. Tropical biomedicine, 28 ((1)): (102-110). [PMID:21602775] |
31. Carol R Gardner,Vladimir Mishin,Jeffrey D Laskin,Debra L Laskin. (2011-11-04) Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole.. Toxicological sciences : an official journal of the Society of Toxicology, 125 ((2)): (607-612). [PMID:22048645] |
32. Qiwen Duan,Yanfeng Liu,Carmen J Booth,Sara Rockwell. (2012-07-11) Use of fenbendazole-containing therapeutic diets for mice in experimental cancer therapy studies.. Journal of the American Association for Laboratory Animal Science : JAALAS, 51 ((2)): (224-230). [PMID:22776123] |
33. A C Clark,F R López,J M Levine,J J Cooper,T M Craig,A K Voges,M C Johnson,B F Porter. (2012-11-14) Intracranial migration of Eucoleus (Capillaria) boehmi in a dog.. The Journal of small animal practice, 54 ((2)): (99-103). [PMID:23146113] |
34. E H Spodsberg,J E Miles,F J McEvoy,J L Willesen. (2013-02-05) Spontaneous pneumothorax secondary to granulomatous pneumonia caused by Angiostrongylus vasorum in a dog in Denmark.. The Journal of small animal practice, 54 ((2)): (114-114). [PMID:23373838] |
35. J M Forwood,J O Harris,M R Deveney. (2013-03-16) Efficacy of bath and orally administered praziquantel and fenbendazole against Lepidotrema bidyana Murray, a monogenean parasite of silver perch, Bidyanus bidyanus (Mitchell).. Journal of fish diseases, 36 ((11)): (939-947). [PMID:23488766] |
36. James M Forwood,James O Harris,Marty R Deveney. (2013-09-04) Validation of a rapid counting method for assessing treatment efficacy against Lepidotrema bidyana infecting silver perch Bidyanus bidyanus.. Diseases of aquatic organisms, 105 ((3)): (253-257). [PMID:23999709] |
37. F H Hilscher,E M Hussey,B L Nuttelman,D B Burken,W A Griffin,K J Vander Pol,J P Hutcheson,G E Erickson. (2015-05-29) Impact of sorting before feeding zilpaterol hydrochloride on feedlot performance and carcass characteristics of yearling steers.. Journal of animal science, 93 ((5)): (2285-2296). [PMID:26020325] |
38. A C Pesta,B L Nuttelman,A L Shreck,W A Griffin,T J Klopfenstein,G E Erickson. (2015-10-07) Finishing performance of feedlot cattle fed condensed distillers solubles.. Journal of animal science, 93 ((9)): (4350-4357). [PMID:26440335] |
39. Fulin Mao, Weizhong Shi, Hongkun Zhao, Wanxin Li, Abolghasem Jouyban, William E. Acree. (2024) Comprehensive solubility study and inter-molecular interactions on fenbendazole dissolved in some aqueous aprotic and protic co-solvent solutions. JOURNAL OF CHEMICAL THERMODYNAMICS, 191 (107231). [PMID:] |
40. Yi Peng, Jie Pan, Fengting Ou, Wenchao Wang, Haihong Hu, Lu Chen, Su Zeng, Kui Zeng, Lushan Yu. (2022) Fenbendazole and its synthetic analog interfere with HeLa cells’ proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway. CHEMICO-BIOLOGICAL INTERACTIONS, 361 (109983). [PMID:35569513] |