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Fexinidazole - 99%, high purity , Cytotoxic, CAS No.59729-37-2, Cytotoxic

≥99%

CAS#: 59729-37-2
Formula: C₁₂H₁₃N₃O₃S
Molecular Weight: 279.31
PubChem CID: 68792

Item Number

F412787

Grouped product items
SKU	Size	Availability	Price
F412787-10mg	10mg	In stock	$93.90
F412787-50mg	50mg	In stock	$134.90
F412787-100mg	100mg	In stock	$196.90
F412787-250mg	250mg	In stock	$344.90
F412787-1g	1g	In stock	$1,030.90

DNA/RNA Synthesis Inhibitors

Basic Description

Synonyms	Fexinidazole \| 59729-37-2 \| 1-Methyl-2-((4-(methylthio)phenoxy)methyl)-5-nitro-1H-imidazole \| Fexinidazol \| Fexinidazolum \| Hoe-239 \| HOE 239 \| UNII-306ERL82IR \| 306ERL82IR \| 1-Methyl-2-((p-(methylthio)phenoxy)methyl)-5-nitroimidazole \| 1-methyl-2-[(4-methylsulfanylphenoxy)m
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Fexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Mechanism of action	Cytotoxic
Product Description	Information Fexinidazole Fexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness). Targets DNA synthesis

Product Properties

ALogP	2.244
Rotatable Bond	5

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THP-1 (11052 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Leishmania infantum (5912 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trypanosoma brucei (78846 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trypanosoma brucei brucei (13300 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Leishmania donovani (89745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trypanosoma cruzi (99888 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trypanosoma brucei gambiense (523 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trypanosoma brucei rhodesiense (7991 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L6 (7924 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Blood (6 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-methyl-2-[(4-methylsulfanylphenoxy)methyl]-5-nitroimidazole
INCHI	InChI=1S/C12H13N3O3S/c1-14-11(13-7-12(14)15(16)17)8-18-9-3-5-10(19-2)6-4-9/h3-7H,8H2,1-2H3
InChi Key	MIWWSGDADVMLTG-UHFFFAOYSA-N
Canonical SMILES	CN1C(=CN=C1COC2=CC=C(C=C2)SC)[N+](=O)[O-]
Isomeric SMILES	CN1C(=CN=C1COC2=CC=C(C=C2)SC)[N+](=O)[O-]
PubChem CID	68792
Molecular Weight	279.31

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
K2219529	Certificate of Analysis	Sep 01, 2022	F412787
K2219531	Certificate of Analysis	Sep 01, 2022	F412787
K2219532	Certificate of Analysis	Sep 01, 2022	F412787
K2219534	Certificate of Analysis	Sep 01, 2022	F412787
K2219542	Certificate of Analysis	Sep 01, 2022	F412787

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 56 mg/mL (200.49 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility	56
DMSO(mM) Max Solubility	200.494074684043
Water(mg / mL) Max Solubility	＜1

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help.

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