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FG-2216 - 96%, high purity , CAS No.223387-75-5
Basic Description
| Synonyms | FG-2216 | 223387-75-5 | FG2216 | (1-chloro-4-hydroxyisoquinoline-3-carbonyl)glycine | N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE | CHEMBL426560 | IOX3;YM311 | RU921DS4Z5 | 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)acetic acid | Glycine, N-[(1-chloro-4-hy |
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| Specifications & Purity | ≥96% |
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| Biochemical and Physiological Mechanisms | FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2. Phase 2. |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Product Description | Information FG-2216 FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2 . Phase 2.
Targets PHD2 (Cell-free assay) 3.9 μM
In vitro FG-2216 shows the ability to stabilize HIF-α to stimulate EPO secretion.
In vivo In male rhesus macaques, FG-2216 (60 mg/kg, p.o.), induces significant and reversible Epo induction, and induces a small elevation of HbF expression. |
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Product Properties
| ALogP | 1.337 |
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| HBD Count | 2 |
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| Rotatable Bond | 3 |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | 2-[(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]acetic acid |
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| INCHI | InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) |
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| InChi Key | OUQVKRKGTAUJQA-UHFFFAOYSA-N |
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| Canonical SMILES | C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O |
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| Isomeric SMILES | C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O |
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| PubChem CID | 6914666 |
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| Molecular Weight | 280.66 |
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Chemical and Physical Properties
| Solubility | Solubility (25°C) In vitro DMSO: 56 mg/mL (199.52 mM); Water: Insoluble; Ethanol: Insoluble; |
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| DMSO(mg / mL) Max Solubility | 56 |
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| DMSO(mM) Max Solubility | 199.52968 |
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| Water(mg / mL) Max Solubility | ＜1 |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
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| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
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