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FGH10019 - 10mM in DMSO, high purity , CAS No.1046045-61-7(DMSO)

  • 10mM in DMSO
Item Number
F656003
Grouped product items
SKUSizeAvailabilityPrice Qty
F656003-1ml
1ml
Available within 8-12 weeks(?)
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$363.90

Basic Description

Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsFGH10019 is a novel sterol regulatory element-binding protein ( SREBP ) inhibitor with IC 50 of 1 μM.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

FGH10019 is a novel sterol regulatory element-binding protein ( SREBP ) inhibitor with IC 50 of 1 μM.

In Vitro

Treatment of the CHO-K1 cells with analog FGH10019 decreases the percentage of the mature form of SREBP-2 (68 kDa) at lower concentrations than treatment with fatostatin. Densitometric analysis of the gels indicates that the IC 50 of analog FGH10019 is approximately 1 μM, which is 5-10 times lower than the IC 50 of fatostatin (appr 10 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FGH10019-treated chow is fed at a dose rate calculated to provide about 0.7 mg analog FGH10019 per day, at about 23 mg/kg body weight, to 5-wk-old male ob/ob mice weighing an average of appr 30 g. After 8 wk on the analog 24-treated chow, the mice gain 8-9 % less weight than control mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 1 μM (SREBP)

Associated Targets(Human)

SREBF2 Tchem Sterol regulatory element-binding protein 2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SREBF1 Tchem Sterol regulatory element-binding protein 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Canonical SMILES CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)NS(=O)(=O)C
Molecular Weight 373.49

Certificates

C of A & Other Certificates

Related Documents

Solution Calculators