Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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F127654-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $64.90 | |
F127654-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $200.90 | |
F127654-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $904.90 |
Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist
Synonyms | FH535 | 108409-83-2 | 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide | beta-Catenin/Tcf Inhibitor, FH535 | N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonamide | FH 535 | FH-535 | CHEMBL2363137 | 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-benzenesulfonamide | |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Description:IC50 Value: 1.1uM (Cytotoxicity in the CCLP-1 cell line) [1] FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. FH535antagonizes both PPAR gamma and PPAR delta ligand |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist. |
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IUPAC Name | 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide |
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INCHI | InChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3 |
InChi Key | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl |
Isomeric SMILES | CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl |
PubChem CID | 3463933 |
Molecular Weight | 361.2 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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F2418004 | Certificate of Analysis | Jun 24, 2024 | F127654 |
H1813151 | Certificate of Analysis | Feb 21, 2024 | F127654 |
H1813150 | Certificate of Analysis | Feb 21, 2024 | F127654 |
H1602011 | Certificate of Analysis | Dec 18, 2023 | F127654 |
Solubility | 25°C: DMSO |
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Refractive Index | 1.65 |
Boil Point(°C) | ~526.3° C at 760 mmHg |
Melt Point(°C) | 202.89°C |
Pictogram(s) | GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H302:Harmful if swallowed H318:Causes serious eye damage |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. |