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FIIN 1 hydrochloride - ≥96%(HPLC), high purity , CAS No.1256152-35-8
Potent, irreversible FGFR inhibitor
Basic Description Specifications & Purity ≥96%(HPLC) Biochemical and Physiological Mechanisms Potent, irreversible FGFR inhibitor (Kdvalues are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kdvalues are 32, 120 and 210 nM respectively); d Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[3-[[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-[4-(diethylamino)butylamino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamide INCHI InChI=1S/C32H39Cl2N7O4/c1-6-26(42)37-23-13-11-12-21(16-23)19-41-30-22(18-36-31(38-30)35-14-9-10-15-39(7-2)8-3)20-40(32(41)43)29-27(33)24(44-4)17-25(45-5)28(29)34/h6,11-13,16-18H,1,7-10,14-15,19-20H2,2-5H3,(H,37,42)(H,35,36,38) InChi Key DNVFTXQYIYFQBW-UHFFFAOYSA-N Canonical SMILES CCN(CC)CCCCNC1=NC=C2CN(C(=O)N(C2=N1)CC3=CC(=CC=C3)NC(=O)C=C)C4=C(C(=CC(=C4Cl)OC)OC)Cl Isomeric SMILES CCN(CC)CCCCNC1=NC=C2CN(C(=O)N(C2=N1)CC3=CC(=CC=C3)NC(=O)C=C)C4=C(C(=CC(=C4Cl)OC)OC)Cl PubChem CID 53348188 Molecular Weight 693.06
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 69.31, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 69.31, Max Conc. mM: 100
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