Click Here for 5% Off Your First Aladdin Purchase!

Fingolimod - 97% , high purity , CAS No.162359-55-9, Activator of K ir3.4;Agonist of S1P 1 receptor;Agonist of S1P 5 receptor;Channel blocker of TRPM7

  • Moligand™
  • ≥97%
Item Number
F305092
Grouped product items
SKUSizeAvailabilityPrice Qty
F305092-50mg
50mg
In stock
$14.90
F305092-250mg
250mg
In stock
$61.90
F305092-1g
1g
In stock
$205.90
F305092-5g
5g
In stock
$815.90

Basic Description

SynonymsFingolimod|162359-55-9|2-Amino-2-(4-octylphenethyl)propane-1,3-diol|2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol|Fty-720|Fingolimod [INN]|2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol|fingolimodum|UNII-3QN8BYN5QF|3QN8BYN5QF|1,3-Propanediol, 2-a
Specifications & PurityMoligand™, ≥97%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR, AGONIST, CHANNEL BLOCKER
Mechanism of actionActivator of K ir3.4;Agonist of S1P 1 receptor;Agonist of S1P 5 receptor;Channel blocker of TRPM7

Associated Targets

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GPR35 Tchem G-protein coupled receptor 35 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CERS2 Tbio Ceramide synthase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

S1PR5 Tclin Sphingosine 1-phosphate receptor 5 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

S1PR2 Tchem Sphingosine 1-phosphate receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

S1PR4 Tclin Sphingosine 1-phosphate receptor 4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPM7 Tchem Transient receptor potential cation channel subfamily M member 7 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SPHK2 Tchem Sphingosine kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FFAR4 Tchem Free fatty acid receptor 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FPR2 Tchem N-formyl peptide receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SPHK1 Tchem Sphingosine kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

S1PR1 Tclin Sphingosine 1-phosphate receptor 1 4 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

S1PR3 Tclin Sphingosine 1-phosphate receptor 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SGPL1 Tchem Sphingosine-1-phosphate lyase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APLNR Tchem Apelin receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNJ5 Tchem G protein-activated inward rectifier potassium channel 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488187419
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488187419
IUPAC Name 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol
INCHI InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
InChi Key KKGQTZUTZRNORY-UHFFFAOYSA-N
Canonical SMILES CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
Isomeric SMILES CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
PubChem CID 107970
Molecular Weight 307.47

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

9 results found

Lot NumberCertificate TypeDateItem
D2314605Certificate of AnalysisFeb 13, 2023 F305092
D2314611Certificate of AnalysisFeb 13, 2023 F305092
D2314612Certificate of AnalysisFeb 13, 2023 F305092
D2314629Certificate of AnalysisFeb 13, 2023 F305092
D2314656Certificate of AnalysisFeb 13, 2023 F305092
B2208202Certificate of AnalysisNov 11, 2021 F305092
B2208329Certificate of AnalysisNov 11, 2021 F305092
B2208457Certificate of AnalysisNov 11, 2021 F305092
B2208464Certificate of AnalysisNov 11, 2021 F305092

Chemical and Physical Properties

SolubilityChloroform (Very Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly)
Melt Point(°C)123-125ºC

Related Documents

References

1. Horga A, Montalban X.  (2008)  FTY720 (fingolimod) for relapsing multiple sclerosis..  Expert Rev Neurother,  (5): (699-714).  [PMID:18457527]
2. Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, Thornton R, Shei GJ, Card D, Keohane C et al..  (2002)  Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists..  Science,  296  (5566): (346-9).  [PMID:11923495]
3. Sanna MG, Liao J, Jo E, Alfonso C, Ahn MY, Peterson MS, Webb B, Lefebvre S, Chun J, Gray N et al..  (2004)  Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate..  J Biol Chem,  279  (14): (13839-48).  [PMID:14732717]
4. Forrest M, Sun SY, Hajdu R, Bergstrom J, Card D, Doherty G, Hale J, Keohane C, Meyers C, Milligan J et al..  (2004)  Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes..  J Pharmacol Exp Ther,  309  (2): (758-68).  [PMID:14747617]
5. Hale JJ, Lynch CL, Neway W, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Parent SA et al..  (2004)  A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists..  J Med Chem,  47  (27): (6662-5).  [PMID:15615513]
6. Cohen JA, Chun J.  (2011)  Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis..  Ann Neurol,  69  (5): (759-77).  [PMID:21520239]
7. Teymouri S, Pourbayram Kaleybar S, Hejazian SS, Hejazian SM, Ansarin K, Ardalan M, Zununi Vahed S.  (2023)  The effect of Fingolimod on patients with moderate to severe COVID-19..  Pharmacol Res Perspect,  11  (1): (e01039).  [PMID:36567519]
8. Demont EH, Bailey JM, Bit RA, Brown JA, Campbell CA, Deeks N, Dowell SJ, Eldred C, Gaskin P, Gray JR et al..  (2016)  Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses..  J Med Chem,  59  (3): (1003-20).  [PMID:26751273]

Solution Calculators