Grouped product items

SKU

Size

Availability

Price

Qty

F126599-100mg

100mg

In stock

$59.90

F126599-250mg

250mg

In stock

$135.90

F126599-1g

In stock

$205.90

F126599-5g

In stock

$815.90

Basic Description

Synonyms	FTY720 \| 6beta-(2-carboxy-2-phenylacetamido)-2,2-dimethylpenam-3alpha-carboxylic acid \| Fingolimod hydrochlorid \| MFCD00939512 \| SR-01000942237 \| 2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diol Hydrochloride \| FTY720-d4 Hydrochloride \| FINGOLIMOD HYD
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	FTY720 is an aminopropanediol cell-permeable EDG-1 (endothelial differential gene 1 receptor) antagonist and immunosuppresive agent. It has been shown to display lymphocyte, or white blood cell, sequestration properties. When FTY720 is phosphorylated, it
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	AGONIST
Mechanism of action	Sphingosine 1-phosphate receptor agonist
Note	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Product Description	Fingolimod (FTY720) is a S1P antagonist with IC50 of 0.033 nM. A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties.

Associated Targets(Human)

STAT3 Tchem Signal transducer and activator of transcription 3 (3313 Activities)

Discover Target: STAT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)

Discover Target: S1PR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THP-1 (11052 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride
INCHI	InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChi Key	SWZTYAVBMYWFGS-UHFFFAOYSA-N
Canonical SMILES	CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl
Isomeric SMILES	CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl
WGK Germany	3
PubChem CID	107969
Molecular Weight	343.93

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
K2218465	Certificate of Analysis	Sep 12, 2024	F126599
K2218536	Certificate of Analysis	Sep 12, 2024	F126599
K2218537	Certificate of Analysis	Sep 12, 2024	F126599
K2218572	Certificate of Analysis	Sep 12, 2024	F126599
K2118490	Certificate of Analysis	Sep 15, 2023	F126599
K2118638	Certificate of Analysis	Sep 15, 2023	F126599
B1527004	Certificate of Analysis	Sep 17, 2022	F126599
A2214235	Certificate of Analysis	Jan 19, 2022	F126599

Chemical and Physical Properties

Solubility	Soluble in DMSO ( 69 mg/ml) at 25 °C, ethanol (69 mg/ml) at 25 °C, methanol, water (69 mg/ml) at 25 °C, DMF (≥20 mg/ml), and 1:1 ethanol:PBS(pH 7.2) (0.2 mg/ml).
Sensitivity	Heat sensitive
Melt Point(°C)	110 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H412:Harmful to aquatic life with long lasting effects H361:Suspected of damaging fertility or the unborn child H362:May cause harm to breast-fed children
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
Merck Index	4083

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Ziqi Zhou, Yan Zhang, Simin Xia, Xi Chen. (2023) Red-Light-Activatable AND-Gated Antitumor Immunosuppressant. Cells, 12 (19): (2351). [PMID:37830565] [10.3390/cells12192351]
2. Fan Yang, Dongju Zhao, Meng Cheng, Yining Liu, Ziyao Chen, Jin Chang, Yan Dou. (2023) mTOR-Mediated Immunometabolic Reprogramming Nanomodulators Enable Sensitive Switching of Energy Deprivation-Induced Microglial Polarization for Alzheimer’s Disease Management. ACS Nano, [PMID:37565731] [10.1021/acsnano.3c03232]
3. Zhou Songlei, Huang Yukun, Chen Yu, Liu Yipu, Xie Laozhi, You Yang, Tong Shiqiang, Xu Jianpei, Jiang Gan, Song Qingxiang, Mei Ni, Ma Fenfen, Gao Xiaoling, Chen Hongzhuan, Chen Jun. (2023) Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma. Nature Communications, 14 (1): (1-20). [PMID:36702831] [10.1038/s41467-023-35957-8]
4. Yan-Jia Che, Xiao-He Ren, Zhi-Wei Wang, Qi Wu, Kai Xing, Min Zhang, Chang Xu, Di Han, Shun Yuan, Si-Hao Zheng, Yuan-Yang Chen, Xin-Ru Liao, Feng Shi, Xiao-Han Zhong, Xin Cai, Si-Xue Cheng. (2022) Lymph-Node-Targeted Drug Delivery for Effective Immunomodulation to Prolong the Long-Term Survival After Heart Transplantation. ADVANCED MATERIALS, 35 (16): (2207227). [PMID:36314402] [10.1002/adma.202207227]
5. Taiying Chen, Ngalei Tam, Yu Mao, Chengjun Sun, Zekang Wang, Yuchen Hou, Wuzheng Xia, Jia Yu, Linwei Wu. (2022) A multi-hit therapeutic nanoplatform for hepatocellular carcinoma: Dual stimuli-responsive drug release, dual-modal imaging, and in situ oxygen supply to enhance synergistic therapy. Materials Today Bio, 16 (100338). [PMID:35847375] [10.1016/j.mtbio.2022.100338]

References

1. Brinkmann V et al.. (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.. Nat Rev Drug Discov, 9 (11): (883-97). [PMID:21031003]
2. Brinkmann V et al.. (2001) FTY720: altered lymphocyte traffic results in allograft protection.. Transplantation, 72 (5): (764-9). [PMID:11571432]
3. Miller DC et al.. (2016) The CII-specific autoimmune T-cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis.. Arthritis Res Ther, 18 (8). [PMID:26757712]
4. Ziqi Zhou, Yan Zhang, Simin Xia, Xi Chen. (2023) Red-Light-Activatable AND-Gated Antitumor Immunosuppressant. Cells, 12 (19): (2351). [PMID:37830565] [10.3390/cells12192351]
5. Fan Yang, Dongju Zhao, Meng Cheng, Yining Liu, Ziyao Chen, Jin Chang, Yan Dou. (2023) mTOR-Mediated Immunometabolic Reprogramming Nanomodulators Enable Sensitive Switching of Energy Deprivation-Induced Microglial Polarization for Alzheimer’s Disease Management. ACS Nano, [PMID:37565731] [10.1021/acsnano.3c03232]
6. Zhou Songlei, Huang Yukun, Chen Yu, Liu Yipu, Xie Laozhi, You Yang, Tong Shiqiang, Xu Jianpei, Jiang Gan, Song Qingxiang, Mei Ni, Ma Fenfen, Gao Xiaoling, Chen Hongzhuan, Chen Jun. (2023) Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma. Nature Communications, 14 (1): (1-20). [PMID:36702831] [10.1038/s41467-023-35957-8]
7. Yan-Jia Che, Xiao-He Ren, Zhi-Wei Wang, Qi Wu, Kai Xing, Min Zhang, Chang Xu, Di Han, Shun Yuan, Si-Hao Zheng, Yuan-Yang Chen, Xin-Ru Liao, Feng Shi, Xiao-Han Zhong, Xin Cai, Si-Xue Cheng. (2022) Lymph-Node-Targeted Drug Delivery for Effective Immunomodulation to Prolong the Long-Term Survival After Heart Transplantation. ADVANCED MATERIALS, 35 (16): (2207227). [PMID:36314402] [10.1002/adma.202207227]
8. Taiying Chen, Ngalei Tam, Yu Mao, Chengjun Sun, Zekang Wang, Yuchen Hou, Wuzheng Xia, Jia Yu, Linwei Wu. (2022) A multi-hit therapeutic nanoplatform for hepatocellular carcinoma: Dual stimuli-responsive drug release, dual-modal imaging, and in situ oxygen supply to enhance synergistic therapy. Materials Today Bio, 16 (100338). [PMID:35847375] [10.1016/j.mtbio.2022.100338]

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Fingolimod HCl - ≥98%, high purity , Sphingosine 1-phosphate receptor agonist, CAS No.162359-56-0, Sphingosine 1-phosphate receptor agonist

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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