Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
F420887-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 |
Potent GABA-gated Cl channel blocker
Synonyms | fipronil | 120068-37-3 | Termidor | Fipronil [ISO] | RM 1601 | MB 46030 | (+/-)-Fipronil | HSDB 7051 | NSC-758960 | UNII-QGH063955F | FRONTLINE | 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-1h-pyrazole-3-carbonitrile | DTXSID4034609 | CHEBI:833 |
---|---|
Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | Potent GABA-gated Cl channel blocker (IC 50 = 28 nM). Use as insecticide and in pesticide cytotoxicity studies. Apoptotic and necrotic potential. Active in vitro . |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
---|
IUPAC Name | 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile |
---|---|
INCHI | InChI=1S/C12H4Cl2F6N4OS/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7(3-21)23-24)26(25)12(18,19)20/h1-2H,22H2 |
InChi Key | ZOCSXAVNDGMNBV-UHFFFAOYSA-N |
Canonical SMILES | C1=C(C=C(C(=C1Cl)N2C(=C(C(=N2)C#N)S(=O)C(F)(F)F)N)Cl)C(F)(F)F |
Isomeric SMILES | C1=C(C=C(C(=C1Cl)N2C(=C(C(=N2)C#N)S(=O)C(F)(F)F)N)Cl)C(F)(F)F |
WGK Germany | 3 |
RTECS | UQ4430250 |
PubChem CID | 3352 |
UN Number | 2811 |
Molecular Weight | 437.15 |
Beilstein | 8090115 |
Reaxy-Rn | 8090115 |
Enter Lot Number to search for COA:
Melt Point(°C) | 196-201°C |
---|
Pictogram(s) | GHS06, GHS08, GHS09 |
---|---|
Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H311:Toxic in contact with skin H331:Toxic if inhaled H410:Very toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P311:Call a POISON CENTER or doctor/... P501:Dispose of contents/container to ... |
WGK Germany | 3 |
RTECS | UQ4430250 |
Reaxy-Rn | 8090115 |
1. Liran Tian, Xiangwei Song, Tianjiao Liu, Anfeng Li, Yang Ning, Xiuyi Hua, Deming Dong, Zhijun Song, Dapeng Liang. (2023) Spectrophotometric Determination of Acetamiprid Using Gold Nanoparticles (AuNPs) with Optimized Truncated Aptamers. ANALYTICAL LETTERS, [PMID:] |
2. Xiaomu Qiao, Tianhao Zhou, Jing Zhang, Lixin Zhang, Yaobin Lu, Jia Huang. (2023) Functional validation of A2′N mutation of the RDL GABA receptor against fipronil via molecular modeling and genome engineering in drosophila. PEST MANAGEMENT SCIENCE, [PMID:38086568] |
3. Ferry Saputra, Yu-Heng Lai, Marri Jmelou M. Roldan, Honeymae C. Alos, Charlaine A. Aventurado, Ross D. Vasquez, Chung-Der Hsiao. (2023) The Effect of the Pyrethroid Pesticide Fenpropathrin on the Cardiac Performance of Zebrafish and the Potential Mechanism of Toxicity. Biology-Basel, 12 (9): (1214). [PMID:37759613] |
4. Shuqin Liu, Yiquan Huang, Yingming Duan, Zhangmin Xiang, Jian Liu, Xi Zhou, Zhiyong Chen. (2024) Volatile/semi-volatile metabolites profiling in living vegetables via a novel covalent triazine framework based solid-phase microextraction fiber coupled with GC-QTOF-MS. FOOD CHEMISTRY, 430 (137064). [PMID:37549619] |
5. Liran Tian, Xiangwei Song, Tianjiao Liu, Anfeng Li, Yang Ning, Xiuyi Hua, Deming Dong, Dapeng Liang. (2023) A combined UV-visible with fluorescence detection method based on an unlabeled aptamer and AuNPs for the sensitive detection of acetamiprid. NEW JOURNAL OF CHEMISTRY, 47 (16): (7722-7732). [PMID:] |
6. Yifan Li, Shujun Ni, Yunping Wang, Ruichi Li, Hong Sun, Xuan Ye, Zhen Tian, Yalin Zhang, Jiyuan Liu. (2023) The chemosensory protein 1 contributes to indoxacarb resistance in Plutella xylostella (L.). PEST MANAGEMENT SCIENCE, [PMID:36809665] |
7. Yuhang Liu, Yi Zhang, Pran Gopal Karmaker, Yuting Tang, Lilei Zhang, Feng Huo, Ya Wang, Xiupei Yang. (2022) Dual-Color 2D Lead–Organic Framework with Two-Fold Interlocking Structures for the Detection of Nitrofuran Antibiotics and 2,6-Dichloro-4-nitroaniline. ACS Applied Materials & Interfaces, 14 (45): (51531–51544). [PMID:36342338] |
8. Xiaoyu Su, Zhiyu Chen, Huan Wang, Lei Yuan, Kaiyi Zheng, Wen Zhang, Xiaobo Zou. (2022) Ratiometric immunosensor with DNA tetrahedron nanostructure as high-performance carrier of reference signal and its applications in selective phoxim determination for vegetables. FOOD CHEMISTRY, 383 (132445). [PMID:35182867] |
9. Liu Guangyan, Li Shiyu, Jiang Zejun, Li Jianping. (2022) A versatile and ultrasensitive molecularly imprinted electrochemiluminescence sensor with HRP-encapsulated liposome labeled by light-triggered click reaction for pesticide residues. MICROCHIMICA ACTA, 189 (1): (1-10). [PMID:34935073] |
10. Chen Shuqin, Huang Mengna, Huang Mianli, Feng Liang. (2021) Fluorometric determination of ziram using CsPbBr3 quantum dots. MICROCHIMICA ACTA, 188 (11): (1-9). [PMID:34677687] |
11. Xu Jing, Jing Wu, Huihui Wang, Luyao Guo, Xiaojiao Zheng, Xiaowen Wang, Shuo Wang. (2022) Application of deep eutectic solvent-based extraction coupled with an S-CQD fluorescent sensor for the determination of pirimicarb in cereals. FOOD CHEMISTRY, 370 (131360). [PMID:34662796] |
12. Xiuping He, Junhui Chen, Xiaotong Li, Jiuming Wang, Ming Xin, Xia Sun, Wei Cao, Baodong Wang. (2021) Pollution status, influencing factors and environmental risks of neonicotinoids, fipronil and its metabolites in a typical semi-closed bay in China. ENVIRONMENTAL POLLUTION, 291 (118210). [PMID:34582920] |
13. Xin Pan, Zhangjun Wang, Chao Chen, Hui Li, Xianxin Li, Quanfeng Zhang, Xiufen Wang, Yanan Zhang. (2020) Research on the distribution of neonicotinoid and fipronil pollution in the Yangtze River by high-performance liquid chromatography. Analytical Methods, 12 (46): (5581-5590). [PMID:33165450] |
14. Cong Wang, Yao Lin, Yichao Wang, Ting-Fu Jiang, Zhihua Lv. (2021) Determination of fipronil and its metabolites in chicken egg by dispersive liquid–liquid microextraction with 19F quantitative nuclear magnetic resonance spectroscopy. MICROCHEMICAL JOURNAL, 160 (105547). [PMID:] |
15. Jing Zhao, Zhaorui Meng, Zexin Zhao, Longshan Zhao. (2020) Ultrasound-assisted deep eutectic solvent as green and efficient media combined with functionalized magnetic multi-walled carbon nanotubes as solid-phase extraction to determine pesticide residues in food products. FOOD CHEMISTRY, 310 (125863). [PMID:31835214] |
16. Lianqing Chen, Zhongda Wu, Yanting Du, Yufeng Huang, Shiwei Jin. (2019) Solvothermal synthesis of novel phenylpyrazole Schiff base fluorescent insecticides fused extended conjugate units for enhancing bioactivities, photophysical and electrochemical properties. JOURNAL OF MOLECULAR STRUCTURE, 1196 (555). [PMID:] |
17. Tianfu Wei, Gongke Li, Zhuomin Zhang. (2019) A covalently cross-linked microporous polymer based micro-solid phase extraction for online analysis of trace pesticide residues in citrus fruits. JOURNAL OF SEPARATION SCIENCE, 42 (4): (888-896). [PMID:30556362] |
18. Bo Zhang, Lei Zhang, Lujue He, Xiaodong Yang, Yali Shi, Shaowei Liao, Shan Yang, Jiagao Cheng, Tianrui Ren. (2018) Interactions of Fipronil within Fish and Insects: Experimental and Molecular Modeling Studies. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66 (23): (5756–5761). [PMID:29627978] |
19. Baoyan Zhang, Zhiping Xu, Yixi Zhang, Xusheng Shao, Xiaoyong Xu, Jiaogao Cheng, Zhong Li. (2015) Fipronil induces apoptosis through caspase-dependent mitochondrial pathways in Drosophila S2 cells. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 119 (81). [PMID:25868821] |
1. Liran Tian, Xiangwei Song, Tianjiao Liu, Anfeng Li, Yang Ning, Xiuyi Hua, Deming Dong, Zhijun Song, Dapeng Liang. (2023) Spectrophotometric Determination of Acetamiprid Using Gold Nanoparticles (AuNPs) with Optimized Truncated Aptamers. ANALYTICAL LETTERS, [PMID:] |
2. Xiaomu Qiao, Tianhao Zhou, Jing Zhang, Lixin Zhang, Yaobin Lu, Jia Huang. (2023) Functional validation of A2′N mutation of the RDL GABA receptor against fipronil via molecular modeling and genome engineering in drosophila. PEST MANAGEMENT SCIENCE, [PMID:38086568] |
3. Ferry Saputra, Yu-Heng Lai, Marri Jmelou M. Roldan, Honeymae C. Alos, Charlaine A. Aventurado, Ross D. Vasquez, Chung-Der Hsiao. (2023) The Effect of the Pyrethroid Pesticide Fenpropathrin on the Cardiac Performance of Zebrafish and the Potential Mechanism of Toxicity. Biology-Basel, 12 (9): (1214). [PMID:37759613] |
4. Shuqin Liu, Yiquan Huang, Yingming Duan, Zhangmin Xiang, Jian Liu, Xi Zhou, Zhiyong Chen. (2024) Volatile/semi-volatile metabolites profiling in living vegetables via a novel covalent triazine framework based solid-phase microextraction fiber coupled with GC-QTOF-MS. FOOD CHEMISTRY, 430 (137064). [PMID:37549619] |
5. Liran Tian, Xiangwei Song, Tianjiao Liu, Anfeng Li, Yang Ning, Xiuyi Hua, Deming Dong, Dapeng Liang. (2023) A combined UV-visible with fluorescence detection method based on an unlabeled aptamer and AuNPs for the sensitive detection of acetamiprid. NEW JOURNAL OF CHEMISTRY, 47 (16): (7722-7732). [PMID:] |
6. Yifan Li, Shujun Ni, Yunping Wang, Ruichi Li, Hong Sun, Xuan Ye, Zhen Tian, Yalin Zhang, Jiyuan Liu. (2023) The chemosensory protein 1 contributes to indoxacarb resistance in Plutella xylostella (L.). PEST MANAGEMENT SCIENCE, [PMID:36809665] |
7. Yuhang Liu, Yi Zhang, Pran Gopal Karmaker, Yuting Tang, Lilei Zhang, Feng Huo, Ya Wang, Xiupei Yang. (2022) Dual-Color 2D Lead–Organic Framework with Two-Fold Interlocking Structures for the Detection of Nitrofuran Antibiotics and 2,6-Dichloro-4-nitroaniline. ACS Applied Materials & Interfaces, 14 (45): (51531–51544). [PMID:36342338] |
8. Xiaoyu Su, Zhiyu Chen, Huan Wang, Lei Yuan, Kaiyi Zheng, Wen Zhang, Xiaobo Zou. (2022) Ratiometric immunosensor with DNA tetrahedron nanostructure as high-performance carrier of reference signal and its applications in selective phoxim determination for vegetables. FOOD CHEMISTRY, 383 (132445). [PMID:35182867] |
9. Liu Guangyan, Li Shiyu, Jiang Zejun, Li Jianping. (2022) A versatile and ultrasensitive molecularly imprinted electrochemiluminescence sensor with HRP-encapsulated liposome labeled by light-triggered click reaction for pesticide residues. MICROCHIMICA ACTA, 189 (1): (1-10). [PMID:34935073] |
10. Chen Shuqin, Huang Mengna, Huang Mianli, Feng Liang. (2021) Fluorometric determination of ziram using CsPbBr3 quantum dots. MICROCHIMICA ACTA, 188 (11): (1-9). [PMID:34677687] |
11. Xu Jing, Jing Wu, Huihui Wang, Luyao Guo, Xiaojiao Zheng, Xiaowen Wang, Shuo Wang. (2022) Application of deep eutectic solvent-based extraction coupled with an S-CQD fluorescent sensor for the determination of pirimicarb in cereals. FOOD CHEMISTRY, 370 (131360). [PMID:34662796] |
12. Xiuping He, Junhui Chen, Xiaotong Li, Jiuming Wang, Ming Xin, Xia Sun, Wei Cao, Baodong Wang. (2021) Pollution status, influencing factors and environmental risks of neonicotinoids, fipronil and its metabolites in a typical semi-closed bay in China. ENVIRONMENTAL POLLUTION, 291 (118210). [PMID:34582920] |
13. Xin Pan, Zhangjun Wang, Chao Chen, Hui Li, Xianxin Li, Quanfeng Zhang, Xiufen Wang, Yanan Zhang. (2020) Research on the distribution of neonicotinoid and fipronil pollution in the Yangtze River by high-performance liquid chromatography. Analytical Methods, 12 (46): (5581-5590). [PMID:33165450] |
14. Cong Wang, Yao Lin, Yichao Wang, Ting-Fu Jiang, Zhihua Lv. (2021) Determination of fipronil and its metabolites in chicken egg by dispersive liquid–liquid microextraction with 19F quantitative nuclear magnetic resonance spectroscopy. MICROCHEMICAL JOURNAL, 160 (105547). [PMID:] |
15. Jing Zhao, Zhaorui Meng, Zexin Zhao, Longshan Zhao. (2020) Ultrasound-assisted deep eutectic solvent as green and efficient media combined with functionalized magnetic multi-walled carbon nanotubes as solid-phase extraction to determine pesticide residues in food products. FOOD CHEMISTRY, 310 (125863). [PMID:31835214] |
16. Lianqing Chen, Zhongda Wu, Yanting Du, Yufeng Huang, Shiwei Jin. (2019) Solvothermal synthesis of novel phenylpyrazole Schiff base fluorescent insecticides fused extended conjugate units for enhancing bioactivities, photophysical and electrochemical properties. JOURNAL OF MOLECULAR STRUCTURE, 1196 (555). [PMID:] |
17. Tianfu Wei, Gongke Li, Zhuomin Zhang. (2019) A covalently cross-linked microporous polymer based micro-solid phase extraction for online analysis of trace pesticide residues in citrus fruits. JOURNAL OF SEPARATION SCIENCE, 42 (4): (888-896). [PMID:30556362] |
18. Bo Zhang, Lei Zhang, Lujue He, Xiaodong Yang, Yali Shi, Shaowei Liao, Shan Yang, Jiagao Cheng, Tianrui Ren. (2018) Interactions of Fipronil within Fish and Insects: Experimental and Molecular Modeling Studies. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 66 (23): (5756–5761). [PMID:29627978] |
19. Baoyan Zhang, Zhiping Xu, Yixi Zhang, Xusheng Shao, Xiaoyong Xu, Jiaogao Cheng, Zhong Li. (2015) Fipronil induces apoptosis through caspase-dependent mitochondrial pathways in Drosophila S2 cells. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 119 (81). [PMID:25868821] |