Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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F156691-250mg | 250mg | In stock | $60.90 | |
F156691-1g | 1g | In stock | $128.90 | |
F156691-5g | 5g | In stock | $470.90 |
Potent sirtuin-activating compound (STAC). Plant flavonol.
Synonyms | 3,4',7-Tetrahydroxyflavone | 7,3',4'-Trihydroxyflavonol | HY-N0182 | MFCD00006829 | NCGC00095663-01 | 5-Deoxyquercetin | Fustet | UNII-OO2ABO9578 | BIDD:ER0141 | NSC407010 | NSC-407010 | Spectrum5_001797 | BRN 0292829 | C.I. Natural Brown 1 | KBioSS_00167 |
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Specifications & Purity | Moligand™, ≥96%(HPLC) |
Biochemical and Physiological Mechanisms | Potent sirtuin-activating compound (STAC). Plant flavonol with various pharmacological effects. Anti-inflammatory, anticarcinogenic and antiviral activities . |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Note | Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one |
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INCHI | InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H |
InChi Key | XHEFDIBZLJXQHF-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O |
Isomeric SMILES | C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O |
RTECS | LK9250000 |
PubChem CID | 5281614 |
Molecular Weight | 286.24 |
Beilstein | 18221 |
Reaxy-Rn | 292829 |
CAS Registry No. | 528-48-3 |
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Wikipedia | Fisetin |
ChEBI | CHEBI:42567 |
PubChem CID | 5281614 |
BitterDB Ligand | 882 |
ChEMBL Ligand | CHEMBL31574 |
RCSB PDB Ligand | FSE |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2320339 | Certificate of Analysis | Nov 06, 2023 | F156691 |
K2320351 | Certificate of Analysis | Nov 06, 2023 | F156691 |
K2320353 | Certificate of Analysis | Nov 06, 2023 | F156691 |
E2311159 | Certificate of Analysis | Mar 14, 2022 | F156691 |
J2212249 | Certificate of Analysis | Mar 14, 2022 | F156691 |
J2212250 | Certificate of Analysis | Mar 14, 2022 | F156691 |
Solubility | Solubility in water: Practically insoluble; Soluble in Acetone,Methanol; Very slightly soluble in Chloroform,Benzene,Ether |
---|---|
Melt Point(°C) | 330°C |
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
RTECS | LK9250000 |
Reaxy-Rn | 292829 |
Merck Index | 4088 |
1. Nayun Kim, Junhye Kwon, Ui Sup Shin, Joohee Jung. (2023) Fisetin induces the upregulation of AKAP12 mRNA and anti-angiogenesis in a patient-derived organoid xenograft model. BIOMEDICINE & PHARMACOTHERAPY, 167 (6): (115613). [PMID:37801904] [10.1016/j.biopha.2023.115613] |
2. Fangjie Han, Shulin Luo, Zhifang Wu, Zhishan Liang, Wenxin Yang, Dongxue Han, Zhonghui Sun, Zhenbang Liu, Li Niu. (2023) A label-free photoelectrochemical sensor based on BiVO4@graphene oxide hybrid for analysis of the antioxidant capacity in food. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 946 (117713). [PMID:] [10.1016/j.jelechem.2023.117713] |
3. Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao. (2023) Impact of dietary plant flavonoids on 7,8-dihydroxyflavone transepithelial transport in human intestinal Caco-2 cells. Food Science & Nutrition, [PMID:37970375] [10.1002/fsn3.3581] |
4. Xiao-Hua Zhang, Xiang-Dong Qing, Jing-Jing Zheng, Yan Yu, Jiaojiao Huang, Chao Kang, Zhi Liu. (2023) Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey. Food Chemistry-X, 19 (100766). [PMID:37780266] [10.1016/j.fochx.2023.100766] |
5. Sichao Gu, Xuefeng Zhou, Xingshi Yuan, Yunliang Zhu, Hui Zhang, Lei Xu, Li Li. (2023) Photocurable fisetin silk fibroin hydrogel accelerates infected diabetic wounds healing through biofilm inhibition and macrophage immunomodulation. MATERIALS LETTERS, 341 (134154). [PMID:] [10.1016/j.matlet.2023.134154] |
6. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng. (2023) Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 196 (210). [PMID:36724705] [10.1016/j.plaphy.2023.01.050] |
7. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li. (2023) Stability and antioxidant activity of phenolic compounds during in vitro digestion. JOURNAL OF FOOD SCIENCE, 88 (2): (696-716). [PMID:36617678] [10.1111/1750-3841.16440] |
8. Hongting Deng, Yuanju He, Hui Cao, Lei Chen, Hui Teng. (2022) New insight into the effect of hydroxyl substituted flavonoids on the cytotoxicity of 2-amino-3-methylimidazo[4,5-f]quinoline. Food Frontiers, 4 (1): (289-296). [PMID:] [10.1002/fft2.194] |
9. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo. (2023) Chemical composition and anti-inflammatory activities of Castanopsis honey. Food & Function, 14 (1): (250-261). [PMID:36484340] [10.1039/D2FO02233H] |
10. Xiaochong Song, Qing Luo, Xiaojia Huang. (2022) Speciation of organotin compounds in water and seafood samples by online hyphenation of porous polymer-based magnetism-enhanced in-tube solid phase microextraction and HPLC. ANALYTICA CHIMICA ACTA, 1223 (340175). [PMID:35998999] [10.1016/j.aca.2022.340175] |
11. Ming Guan, Xiaojing Kang, Le Wei, Xingjun Hu, Chao Han, Xing Li, Hanwen Liu, Liang Qu, Zhenwen Zhao. (2022) A dual-mode strategy combining SERS with MALDI FTICR MS based on core-shell silver nanoparticles for dye identification and semi-quantification in unearthed silks from Tang Dynasty. TALANTA, 241 (123277). [PMID:35121543] [10.1016/j.talanta.2022.123277] |
12. Zhang Xiao-Hua, Ma Yi-Xin, Yi Chong, Qing Xiang-Dong, Liu Zhi, Zheng Jing-Jing, Lin Fang, Lv Tian-Feng. (2020) Chemometrics-enhanced HPLC–DAD as a rapid and interference-free strategy for simultaneous quantitative analysis of flavonoids in Chinese propolis. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 246 (10): (1909-1918). [PMID:] [10.1007/s00217-020-03543-7] |
13. Wei Yang, Zhi-Kai Tian, Hui-Xin Yang, Zhao-Jun Feng, Jian-Mei Sun, Hong Jiang, Chao Cheng, Qing-Lei Ming, Chan-Min Liu. (2019) Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway. FOOD AND CHEMICAL TOXICOLOGY, 134 (110824). [PMID:31539617] [10.1016/j.fct.2019.110824] |
14. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355] |
15. Ni Zeng, Guowen Zhang, Xing Hu, Junhui Pan, Deming Gong. (2019) Mechanism of fisetin suppressing superoxide anion and xanthine oxidase activity. Journal of Functional Foods, 58 (1). [PMID:] [10.1016/j.jff.2019.04.044] |
16. Yike Yue, Yongsheng Chen, Sheng Geng, Guizhao Liang, Benguo Liu. (2018) Antioxidant and α-Glucosidase Inhibitory Activities of Fisetin. Natural Product Communications, [PMID:] [10.1177/1934578X1801301119] |
17. Hui Wang, Wenxi Zhang, Yatao Cheng, Xinyu Zhang, Nannan Xue, Gaorong Wu, Meng Chen, Kang Fang, Wenbo Guo, Fei Zhou, Herong Cui, Tao Ma, Penglong Wang, Haimin Lei. (2018) Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents. MOLECULES, 23 (9): (2187). [PMID:30200208] [10.3390/molecules23092187] |
18. Tingting Wang, Huajuan Lin, Qian Tu, Jingjing Liu, Xican Li. (2016) Fisetin Protects DNA Against Oxidative Damage and Its Possible Mechanism. Advanced Pharmaceutical Bulletin, 6 (2): ( 267–270). [PMID:27478791] [10.15171/apb.2016.037] |
19. Xiaodan Liu, Xia Wu. (2014) Fluorescence enhancement of fisetin by silver nanoparticles with cetyltrimethyl ammonium bromide micelles. RSC Advances, 5 (10): (7433-7439). [PMID:] [10.1039/C4RA12726A] |
20. Zhenning Xu, Mo Wang, Tingting Zhou, Huanshun Yin, Shiyun Ai. (2013) Electrochemical biosensing method for the detection of DNA methylation and assay of the methyltransferase activity. SENSORS AND ACTUATORS B-CHEMICAL, 178 (412). [PMID:] [10.1016/j.snb.2012.12.124] |
21. Huanshun Yin, Zhenning Xu, Mo Wang, Xueping Zhang, Shiyun Ai. (2013) An electrochemical biosensor for assay of DNA methyltransferase activity and screening of inhibitor. ELECTROCHIMICA ACTA, 89 (530). [PMID:] [10.1016/j.electacta.2012.11.093] |
22. Huanshun Yin, Yunlei Zhou, Zhenning Xu, Lijian Chen, Di Zhang, Shiyun Ai. (2013) An electrochemical assay for DNA methylation, methyltransferase activity and inhibitor screening based on methyl binding domain protein. BIOSENSORS & BIOELECTRONICS, 41 (492). [PMID:23021851] [10.1016/j.bios.2012.09.010] |
23. Shujuan Xu, Yong Shao, Kun Ma, Qinghua Cui, Guiying Liu, Fei Wu, Minjie Li. (2011) Fluorescence light-up recognition of DNA nucleotide based on selective abasic site binding of an excited-state intramolecular proton transfer probe. ANALYST, 136 (21): (4480-4485). [PMID:21946800] [10.1039/C1AN15652G] |
1. Nayun Kim, Junhye Kwon, Ui Sup Shin, Joohee Jung. (2023) Fisetin induces the upregulation of AKAP12 mRNA and anti-angiogenesis in a patient-derived organoid xenograft model. BIOMEDICINE & PHARMACOTHERAPY, 167 (6): (115613). [PMID:37801904] [10.1016/j.biopha.2023.115613] |
2. Fangjie Han, Shulin Luo, Zhifang Wu, Zhishan Liang, Wenxin Yang, Dongxue Han, Zhonghui Sun, Zhenbang Liu, Li Niu. (2023) A label-free photoelectrochemical sensor based on BiVO4@graphene oxide hybrid for analysis of the antioxidant capacity in food. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 946 (117713). [PMID:] [10.1016/j.jelechem.2023.117713] |
3. Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao. (2023) Impact of dietary plant flavonoids on 7,8-dihydroxyflavone transepithelial transport in human intestinal Caco-2 cells. Food Science & Nutrition, [PMID:37970375] [10.1002/fsn3.3581] |
4. Xiao-Hua Zhang, Xiang-Dong Qing, Jing-Jing Zheng, Yan Yu, Jiaojiao Huang, Chao Kang, Zhi Liu. (2023) Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey. Food Chemistry-X, 19 (100766). [PMID:37780266] [10.1016/j.fochx.2023.100766] |
5. Sichao Gu, Xuefeng Zhou, Xingshi Yuan, Yunliang Zhu, Hui Zhang, Lei Xu, Li Li. (2023) Photocurable fisetin silk fibroin hydrogel accelerates infected diabetic wounds healing through biofilm inhibition and macrophage immunomodulation. MATERIALS LETTERS, 341 (134154). [PMID:] [10.1016/j.matlet.2023.134154] |
6. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng. (2023) Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 196 (210). [PMID:36724705] [10.1016/j.plaphy.2023.01.050] |
7. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li. (2023) Stability and antioxidant activity of phenolic compounds during in vitro digestion. JOURNAL OF FOOD SCIENCE, 88 (2): (696-716). [PMID:36617678] [10.1111/1750-3841.16440] |
8. Hongting Deng, Yuanju He, Hui Cao, Lei Chen, Hui Teng. (2022) New insight into the effect of hydroxyl substituted flavonoids on the cytotoxicity of 2-amino-3-methylimidazo[4,5-f]quinoline. Food Frontiers, 4 (1): (289-296). [PMID:] [10.1002/fft2.194] |
9. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo. (2023) Chemical composition and anti-inflammatory activities of Castanopsis honey. Food & Function, 14 (1): (250-261). [PMID:36484340] [10.1039/D2FO02233H] |
10. Xiaochong Song, Qing Luo, Xiaojia Huang. (2022) Speciation of organotin compounds in water and seafood samples by online hyphenation of porous polymer-based magnetism-enhanced in-tube solid phase microextraction and HPLC. ANALYTICA CHIMICA ACTA, 1223 (340175). [PMID:35998999] [10.1016/j.aca.2022.340175] |
11. Ming Guan, Xiaojing Kang, Le Wei, Xingjun Hu, Chao Han, Xing Li, Hanwen Liu, Liang Qu, Zhenwen Zhao. (2022) A dual-mode strategy combining SERS with MALDI FTICR MS based on core-shell silver nanoparticles for dye identification and semi-quantification in unearthed silks from Tang Dynasty. TALANTA, 241 (123277). [PMID:35121543] [10.1016/j.talanta.2022.123277] |
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