The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
FK 888 - ≥98%(HPLC), high purity , CAS No.138449-07-7, Antagonist of NK 1 receptor;Antagonist of NK 2 receptor
High affinity NK1antagonist
Basic Description Synonyms DTXSID70160680 | (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide | FK888 | FK-888 | FK 888 | L-Alaninamide, (4R)-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2- Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Selective, high affinity tachykinin NK1receptor antagonist (Ki= 0.69 nM) that displays 320-fold selectivity for human over rat NK1receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC50= 32 nM) and inhibits substance P-ind Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of NK 1 receptor;Antagonist of NK 2 receptor
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2S,4R)-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-4-hydroxy-1-(1-methylindole-3-carbonyl)pyrrolidine-2-carboxamide INCHI InChI=1S/C36H36N4O4/c1-38-23-30(29-14-8-9-15-32(29)38)35(43)40-22-28(41)20-33(40)34(42)37-31(36(44)39(2)21-24-10-4-3-5-11-24)19-25-16-17-26-12-6-7-13-27(26)18-25/h3-18,23,28,31,33,41H,19-22H2,1-2H3,(H,37,42)/t28-,31+,33+/m1/s1 InChi Key BFNKQTIJVFGCKQ-PDJGWCFMSA-N Canonical SMILES CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O Isomeric SMILES CN1C=C(C2=CC=CC=C21)C(=O)N3C[C@@H](C[C@H]3C(=O)N[C@@H](CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O PubChem CID 107967 Molecular Weight 588.69
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 58.87, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 58.87, Max Conc. mM: 100
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
