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Flavokawain A - ≥99%, high purity , CAS No.64680-84-8
Chalcone from kava. Apoptotic agent.
Basic Description Synonyms (E)-1-(2-hydroxy-4,6-dimethoxy-phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one | 2'-Hydroxy-4,4',6'-trimethoxychalcone | NSC37445 | NSC-37445 | CS-0022627 | (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one | Oxacillin (INN) | A875070 | Specifications & Purity ≥99% Biochemical and Physiological Mechanisms Chalcone from kava. Decreases cyclin dependent kinase-2 (CDK2) inducing G2-M arrest in vitro . Antiproliferative and apoptotic effects. Storage Temp Protected from light,Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one INCHI InChI=1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+ InChi Key CGIBCVBDFUTMPT-RMKNXTFCSA-N Canonical SMILES COC1=CC=C(C=C1)C=CC(=O)C2=C(C=C(C=C2OC)OC)O Isomeric SMILES COC1=CC=C(C=C1)/C=C/C(=O)C2=C(C=C(C=C2OC)OC)O Alternate CAS 3420-72-2、37951-13-6 PubChem CID 5355469 Molecular Weight 314.33
Chemical and Physical Properties Solubility Soluble in DMSO to 100 mM Sensitivity light sensitive
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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C2307440