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F114259-100mg

100mg

Available within 4-8 weeks(?)

$342.90

Basic Description

Synonyms	6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid \| 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid \| 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl
Specifications & Purity	Moligand™, analytical standard
Biochemical and Physiological Mechanisms	Broad-spectrum antibiotic agent. Topoisomerases II- IV inhibitor. Potentiates the antitumor effects of 5-fluorouracil. Shows antiproliferative and bactericidal effects in vivo. Orally active.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	analytical standard, Moligand™
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(non-human)

gyrB DNA gyrase subunit B (290 Activities)

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Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

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Pde4d Phosphodiesterase 4D (4 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Streptococcus pneumoniae (31063 Activities)

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Plasmodium yoelii yoelii (73 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Enterobacter cloacae (7976 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Proteus vulgaris (5823 Activities)

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Providencia rettgeri (925 Activities)

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Bacteroides fragilis (1445 Activities)

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Bacteroides thetaiotaomicron (562 Activities)

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Micrococcus luteus (7463 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus haemolyticus (1695 Activities)

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Citrobacter freundii (1864 Activities)

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Enterobacter (462 Activities)

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Klebsiella aerogenes (4963 Activities)

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Escherichia coli (133304 Activities)

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Klebsiella oxytoca (929 Activities)

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Morganella morganii (1291 Activities)

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Proteus mirabilis (3894 Activities)

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Serratia marcescens (3237 Activities)

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Haemophilus influenzae (8812 Activities)

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Streptococcus pyogenes (16140 Activities)

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Bacillus subtilis (32866 Activities)

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Clostridioides difficile (2968 Activities)

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Hathewaya histolytica (12 Activities)

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Clostridium perfringens (1165 Activities)

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Enterococcus faecalis (29875 Activities)

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Plasmodium falciparum (966862 Activities)

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Mus musculus (284745 Activities)

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V79 (1637 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Plasma (328 Activities)

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gyrB DNA gyrase (2092 Activities)

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Glra2 Glycine receptor (1745 Activities)

Discover Target: Glra2

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

IUPAC Name	6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
INCHI	InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
InChi Key	XBJBPGROQZJDOJ-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F
Isomeric SMILES	CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F
RTECS	VB1999050
PubChem CID	3357
Molecular Weight	369.34
Reaxy-Rn	4300996

Database links

Antibiotic DB	2046
PubChem CID	3357
ChEMBL Ligand	CHEMBL6273
ChEBI	CHEBI:31810
DrugBank Ligand	DB04576
DrugCentral Ligand	1177
CAS Registry No.	79660-72-3
Wikipedia	Fleroxacin

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

Pictogram(s)	GHS07
RTECS	VB1999050
Reaxy-Rn	4300996
Merck Index	4099

Citations of This Product

1. Qi Pu, Lu Zhang, Nengsheng Ye, Yuhong Xiang. (2024) Lanthanide coordination carbon quantum dots construct a ratiometric fluorescent sensor for the detection of norfloxacin in milk. DYES AND PIGMENTS, 222 (111815). [PMID:2576652]
2. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li. (2023) Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin. ACS Applied Nano Materials, 6 (18): (17040–17052). [PMID:11485546]
3. Changxing Wang, Feifei Qin, Siyuan Tang, Xiameng Li, Tingting Li, Guoqiang Guo, Chenjie Gu, Xu Wang, Da Chen. (2023) Construction of graphene quantum dots ratiometric fluorescent probe by intermolecular electron transfer effect for intelligent and real-time visual detection of ofloxacin and its L-isomer in daily drink. FOOD CHEMISTRY, 411 (135514). [PMID:36724609]
4. Zhenyu Lu, Gongke Li, Yufei Hu. (2022) A Tb3+ functionalized triazine-porous organic framework as a ratiometric fluorescent sensor for determination of ciprofloxacin in aquatic products. NEW JOURNAL OF CHEMISTRY, 46 (40): (19153-19160). [PMID:]
5. Boqiang Gao, Yu Pan, Hu Yang. (2022) Enhanced photo-Fenton degradation of fluoroquinolones in water assisted by a 3D composite sponge complexed with a S-scheme MoS2/Bi2S3/BiVO4 ternary photocatalyst. APPLIED CATALYSIS B-ENVIRONMENTAL, 315 (121580). [PMID:]
6. Boqiang Gao, Koukou Tao, Zhonghua Xi, Mayyada M.H. El-Sayed, Tamer Shoeib, Hu Yang. (2022) Fabrication of 3D lignosulfonate composited sponges impregnated by BiVO4/polyaniline/Ag ternary photocatalyst for synergistic adsorption-photodegradation of fluoroquinolones in water. CHEMICAL ENGINEERING JOURNAL, 446 (137282). [PMID:]
7. Jin'ai Chen, Yuting Jin, Taotao Ren, Shuo Wang, Xianghong Wang, Fuyuan Zhang, Yiwei Tang. (2022) A novel terbium (III) and aptamer-based probe for label-free detection of three fluoroquinolones in honey and water samples. FOOD CHEMISTRY, 386 (132751). [PMID:35334319]
8. Lili Lian,Xinyang Zhang,Jie Hao,Jinyi Lv,Xiyue Wang,Bo Zhu,Dawei Lou. (2018-10-26) Magnetic solid-phase extraction of fluoroquinolones from water samples using titanium-based metal-organic framework functionalized magnetic microspheres.. Journal of chromatography. A, 1579 (1-8). [PMID:30352707]

References

1. Rusu A, Lungu IA, Moldovan OL, Tanase C, Hancu G. (2021) Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones-Shaping the Fifth Generation.. Pharmaceutics, 13 (8): (589-97). [PMID:34452252]
2. Hirai K, Aoyama H, Hosaka M, Oomori Y, Niwata Y, Suzue S, Irikura T. (1986) In vitro and in vivo antibacterial activity of AM-833, a new quinolone derivative.. Antimicrob Agents Chemother, 29 (6): (1059-66). [PMID:2942103]
3. Balfour JA, Todd PA, Peters DH. (1995) Fleroxacin. A review of its pharmacology and therapeutic efficacy in various infections.. Drugs, 49 (5): (794-850). [PMID:7601015]
4. Qi Pu, Lu Zhang, Nengsheng Ye, Yuhong Xiang. (2024) Lanthanide coordination carbon quantum dots construct a ratiometric fluorescent sensor for the detection of norfloxacin in milk. DYES AND PIGMENTS, 222 (111815). [PMID:2576652]
5. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li. (2023) Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin. ACS Applied Nano Materials, 6 (18): (17040–17052). [PMID:11485546]
6. Changxing Wang, Feifei Qin, Siyuan Tang, Xiameng Li, Tingting Li, Guoqiang Guo, Chenjie Gu, Xu Wang, Da Chen. (2023) Construction of graphene quantum dots ratiometric fluorescent probe by intermolecular electron transfer effect for intelligent and real-time visual detection of ofloxacin and its L-isomer in daily drink. FOOD CHEMISTRY, 411 (135514). [PMID:36724609]
7. Zhenyu Lu, Gongke Li, Yufei Hu. (2022) A Tb3+ functionalized triazine-porous organic framework as a ratiometric fluorescent sensor for determination of ciprofloxacin in aquatic products. NEW JOURNAL OF CHEMISTRY, 46 (40): (19153-19160). [PMID:]
8. Boqiang Gao, Yu Pan, Hu Yang. (2022) Enhanced photo-Fenton degradation of fluoroquinolones in water assisted by a 3D composite sponge complexed with a S-scheme MoS2/Bi2S3/BiVO4 ternary photocatalyst. APPLIED CATALYSIS B-ENVIRONMENTAL, 315 (121580). [PMID:]
9. Boqiang Gao, Koukou Tao, Zhonghua Xi, Mayyada M.H. El-Sayed, Tamer Shoeib, Hu Yang. (2022) Fabrication of 3D lignosulfonate composited sponges impregnated by BiVO4/polyaniline/Ag ternary photocatalyst for synergistic adsorption-photodegradation of fluoroquinolones in water. CHEMICAL ENGINEERING JOURNAL, 446 (137282). [PMID:]
10. Jin'ai Chen, Yuting Jin, Taotao Ren, Shuo Wang, Xianghong Wang, Fuyuan Zhang, Yiwei Tang. (2022) A novel terbium (III) and aptamer-based probe for label-free detection of three fluoroquinolones in honey and water samples. FOOD CHEMISTRY, 386 (132751). [PMID:35334319]
11. Lili Lian,Xinyang Zhang,Jie Hao,Jinyi Lv,Xiyue Wang,Bo Zhu,Dawei Lou. (2018-10-26) Magnetic solid-phase extraction of fluoroquinolones from water samples using titanium-based metal-organic framework functionalized magnetic microspheres.. Journal of chromatography. A, 1579 (1-8). [PMID:30352707]

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Fleroxacin - analytical standard, high purity , CAS No.79660-72-3

Basic Description

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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