The store will not work correctly when cookies are disabled.
FLT3-IN-3 , CAS No.2229050-90-0, Inhibitor of fms related receptor tyrosine kinase 3
Basic Description
| Specifications & Purity | Moligand™ |
|---|
| Biochemical and Physiological Mechanisms | FLT3-IN-3 is a potent inhibitor of FLT3 with IC50 of 13 nM and 8 nM for FLT3 WT and FLT3 D835Y, respectively. |
|---|
| Storage Temp | Store at -20°C |
|---|
| Shipped In | Ice chest + Ice pads |
|---|
| Grade | Moligand™ |
|---|
| Action Type | INHIBITOR |
|---|
| Mechanism of action | Inhibitor of fms related receptor tyrosine kinase 3 |
|---|
| Product Description | Information FLT3-IN-3 is a potent inhibitor of FLT3 with IC50 of 13 nM and 8 nM for FLT3 WT and FLT3 D835Y, respectively. |
|---|
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| IUPAC Name | 2-N-(4-aminocyclohexyl)-9-cyclopentyl-6-N-[4-(morpholin-4-ylmethyl)phenyl]purine-2,6-diamine |
|---|
| INCHI | InChI=1S/C27H38N8O/c28-20-7-11-22(12-8-20)31-27-32-25(24-26(33-27)35(18-29-24)23-3-1-2-4-23)30-21-9-5-19(6-10-21)17-34-13-15-36-16-14-34/h5-6,9-10,18,20,22-23H,1-4,7-8,11-17,28H2,(H2,30,31,32,33) |
|---|
| InChi Key | SAEGVASGMTZGFI-UHFFFAOYSA-N |
|---|
| Canonical SMILES | C1CCC(C1)N2C=NC3=C(N=C(N=C32)NC4CCC(CC4)N)NC5=CC=C(C=C5)CN6CCOCC6 |
|---|
| Isomeric SMILES | C1CCC(C1)N2C=NC3=C(N=C(N=C32)NC4CCC(CC4)N)NC5=CC=C(C=C5)CN6CCOCC6 |
|---|
| PubChem CID | 133081975 |
|---|
| Molecular Weight | 490.6 |
|---|
References
| 1. Gucký T, Řezníčková E, Radošová Muchová T, Jorda R, Klejová Z, Malínková V, Berka K, Bazgier V, Ajani H, Lepšík M et al.. (2018) Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations.. J Med Chem, 61 (9): (3855-3869). [PMID:29672049] [10.1021/op500134e] |
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
