Fluconazole - ≥98.0%, high purity , Cytochrome P450 51 inhibitor, CAS No.86386-73-4, Cytochrome P450 51 inhibitor

11 Citations
  • ≥98%
Item Number
E129360
Grouped product items
SKUSizeAvailabilityPrice Qty
E129360-1g
1g
In stock
$77.90
E129360-5g
5g
In stock
$240.90
E129360-10g
10g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$432.90
E129360-25g
25g
In stock
$973.90
E129360-100g
100g
In stock
$3,504.90
E129360-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$15,769.90

Triazole antifungal agent. Cytochrome P450 inhibitor.

Basic Description

SynonymsElazor | Flucostat | Fungata | Triflucan | difluconazole | Syscan | Cryptal | 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol | Biozole | Biozolene | Zonal | Fluconazol | Diflucan | Flucoral | Pritenzol | Baten | Loitin | Forcan | Fluconazol
Specifications & Purity≥98%
Biochemical and Physiological MechanismsFluconazole is a triazole broad-spectrum antifungal agent which is effective against Candida spp., cryptococcus neoformans and dermatophytes. Fluconazole is an inhibitor of CYP2C19, CYP2C9 and CYP3A4.Triazole antifungal agent. Cytochrome P450 inhibitor (I
Storage TempStore at 2-8°C
Shipped InWet ice
Action TypeINHIBITOR
Mechanism of actionCytochrome P450 51 inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Introduction

Fluconazole is used to treat adult neutropenic patients with invasive candidiasis (IC).


Application

Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants.

Associated Targets(non-human)

ERG11 Cytochrome P450 51 (617 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Alpha-chymotrypsin (819 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cyp11b2 Cytochrome P450 11B2 (46 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1a P-glycoprotein 3 (492 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHS1 Chitin synthase 1 (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HD1 Histone deacetylase (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichophyton benhamiae (1686 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nannizzia gypsea (2039 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rhizopus arrhizus (810 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Microsporum canis (872 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Naganishia albida (59 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus nidulans (364 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fusarium solani (1274 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella typhimurium (15756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Micrococcus luteus (7463 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella aerogenes (4963 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella oxytoca (929 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Proteus mirabilis (3894 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella typhi (4293 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Shigella dysenteriae (933 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus mutans (2687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pyogenes (16140 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus hirae (484 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus (868 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus flavus (8875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus niger (16508 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus sp. (164 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
INCHI InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChi Key RFHAOTPXVQNOHP-UHFFFAOYSA-N
Canonical SMILES C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
Isomeric SMILES C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
WGK Germany 3
RTECS XZ4810000
PubChem CID 3365
Molecular Weight 306.27
Reaxy-Rn 4269710

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot NumberCertificate TypeDateItem
F2428178Certificate of AnalysisJun 18, 2024 E129360
F2428221Certificate of AnalysisJun 18, 2024 E129360
F2428222Certificate of AnalysisJun 18, 2024 E129360
F2428223Certificate of AnalysisJun 18, 2024 E129360
D2423019Certificate of AnalysisApr 26, 2024 E129360
B2216357Certificate of AnalysisDec 12, 2023 E129360
B2216363Certificate of AnalysisDec 12, 2023 E129360
B2216391Certificate of AnalysisDec 12, 2023 E129360
B2216406Certificate of AnalysisDec 12, 2023 E129360
B2216511Certificate of AnalysisDec 12, 2023 E129360
F2105267Certificate of AnalysisMar 14, 2023 E129360
A2107199Certificate of AnalysisOct 24, 2022 E129360
F2008081Certificate of AnalysisApr 26, 2022 E129360
G2311076Certificate of AnalysisDec 21, 2021 E129360
H2316118Certificate of AnalysisDec 21, 2021 E129360

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Chemical and Physical Properties

SolubilitySoluble in water (<1 mg/ml at 25 °C), ethanol (61 mg/ml at 25 °C), and DMSO (61 mg/ml at 25 °C).
Melt Point(°C)138.0-142.0℃

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H412:Harmful to aquatic life with long lasting effects

H302:Harmful if swallowed

H372:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

H371:May cause damage to organs

H362:May cause harm to breast-fed children

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P263:Avoid contact during pregnancy/while nursing.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P308+P316:IF exposed or concerned: Get emergency medical help immediately.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS XZ4810000
Reaxy-Rn 4269710
Merck Index 4122

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Citations of This Product

1. Yinzheng Ma, Jinlei Sui, Yan Wang, Wanying Sun, Guohui Yi, Jinyan Wu, Shi Qiu, Lili Wang, Aihua Zhang, Xiaowen He.  (2023)  RNA-Seq-Based Transcriptomics and GC–MS Quantitative Analysis Reveal Antifungal Mechanisms of Essential Oil of Clausena lansium (Lour.) Skeels Seeds against Candida albicans.  MOLECULES,  28  (24): (8052).  [PMID:38138542]
2. Khaing Zar Myint, Zhuoyu Zhou, Qiandai Shi, Junming Chen, Xinyu Dong, Yongmei Xia.  (2023)  Stevia Polyphenols, Their Antimicrobial and Anti-Inflammatory Properties, and Inhibitory Effect on Digestive Enzymes.  MOLECULES,  28  (22): (7572).  [PMID:38005293]
3. Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li, Ting Liu.  (2023)  Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen.  FOOD AND CHEMICAL TOXICOLOGY,  180  (28): (114011).  [PMID:37660943]
4. Xinying Sui, Xinyu Cheng, Zhaodi Li, Yonghong Wang, Zhenpeng Zhang, Ruyue Yan, Lei Chang, Yanchang Li, Ping Xu, Changzhu Duan.  (2023)  Quantitative proteomics revealed the transition of ergosterol biosynthesis and drug transporters processes during the development of fungal fluconazole resistance.  Biochimica et Biophysica Acta-Gene Regulatory Mechanisms,  1866  (194953).  [PMID:37307946]
5. Meng Wang, Yanwen Zhou, Zhaohui Wang.  (2023)  Unearth the ultrapotent intrinsic fungicidal efficacy of the surface-piercing CuFeSe2-PVP nano-blade.  CHEMICAL ENGINEERING JOURNAL,  464  (142603).  [PMID:]
6. Mingzhu Zhu, Chen He, Jinchuan Zhou, Yi Li, Lilin Qian, Jiaozhen Zhang, Yanan Qiao, Wenqiang Chang, Hongxiang Lou.  (2023)  Liverwort-Derived Metabolites Retard Endophyte Growth and Inspire Antifungal Application.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (12): (4863–4875).  [PMID:36919252]
7. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv.  (2023)  Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  MOLECULES,  28  (3): (1479).  [PMID:36771146]
8. Yu Wang, Zejun Pei, Zaixiang Lou, Hongxin Wang.  (2022)  Evaluation of Anti-Biofilm Capability of Cordycepin Against Candida albicans.  Infection and Drug Resistance,      [PMID:33574683]
9. Yuhao Fu, Ying Li, Yinling Ma, Xueru He, Xuejiao Xun, Yanjun Cui, Liju Fan, Zhanjun Dong.  (2022)  Effects of voriconazole and fluconazole on the pharmacokinetics of almonertinib in rats by UPLC–MS/MS.  BIOMEDICAL CHROMATOGRAPHY,  37  (1): (e5525).  [PMID:36241418]
10. Tao Ye, Shushu Yuan, Yu Kong, Huiqun Yang, Hongming Wei, Yuhe Zhang, Hangqi Jin, Qingxia Yu, Jiaming Liu, Songfang Chen, Jing Sun.  (2022)  Effect of Probiotic Fungi against Cognitive Impairment in Mice via Regulation of the Fungal Microbiota–Gut–Brain Axis.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (29): (9026–9038).  [PMID:35833673]
11. Ma Yinzheng, Wang Yuanxiao, Zhou Xia, Yang Heng, Zhang Huixin, Chen Wenhan, Zhang Haiying, Zhang Yunxia, He Xiaowen.  (2021)  The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains.  Scientific Reports,  11  (1): (1-10).  [PMID:34608206]

References

1. Yinzheng Ma, Jinlei Sui, Yan Wang, Wanying Sun, Guohui Yi, Jinyan Wu, Shi Qiu, Lili Wang, Aihua Zhang, Xiaowen He.  (2023)  RNA-Seq-Based Transcriptomics and GC–MS Quantitative Analysis Reveal Antifungal Mechanisms of Essential Oil of Clausena lansium (Lour.) Skeels Seeds against Candida albicans.  MOLECULES,  28  (24): (8052).  [PMID:38138542]
2. Khaing Zar Myint, Zhuoyu Zhou, Qiandai Shi, Junming Chen, Xinyu Dong, Yongmei Xia.  (2023)  Stevia Polyphenols, Their Antimicrobial and Anti-Inflammatory Properties, and Inhibitory Effect on Digestive Enzymes.  MOLECULES,  28  (22): (7572).  [PMID:38005293]
3. Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li, Ting Liu.  (2023)  Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen.  FOOD AND CHEMICAL TOXICOLOGY,  180  (28): (114011).  [PMID:37660943]
4. Xinying Sui, Xinyu Cheng, Zhaodi Li, Yonghong Wang, Zhenpeng Zhang, Ruyue Yan, Lei Chang, Yanchang Li, Ping Xu, Changzhu Duan.  (2023)  Quantitative proteomics revealed the transition of ergosterol biosynthesis and drug transporters processes during the development of fungal fluconazole resistance.  Biochimica et Biophysica Acta-Gene Regulatory Mechanisms,  1866  (194953).  [PMID:37307946]
5. Meng Wang, Yanwen Zhou, Zhaohui Wang.  (2023)  Unearth the ultrapotent intrinsic fungicidal efficacy of the surface-piercing CuFeSe2-PVP nano-blade.  CHEMICAL ENGINEERING JOURNAL,  464  (142603).  [PMID:]
6. Mingzhu Zhu, Chen He, Jinchuan Zhou, Yi Li, Lilin Qian, Jiaozhen Zhang, Yanan Qiao, Wenqiang Chang, Hongxiang Lou.  (2023)  Liverwort-Derived Metabolites Retard Endophyte Growth and Inspire Antifungal Application.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (12): (4863–4875).  [PMID:36919252]
7. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv.  (2023)  Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  MOLECULES,  28  (3): (1479).  [PMID:36771146]
8. Yu Wang, Zejun Pei, Zaixiang Lou, Hongxin Wang.  (2022)  Evaluation of Anti-Biofilm Capability of Cordycepin Against Candida albicans.  Infection and Drug Resistance,      [PMID:33574683]
9. Yuhao Fu, Ying Li, Yinling Ma, Xueru He, Xuejiao Xun, Yanjun Cui, Liju Fan, Zhanjun Dong.  (2022)  Effects of voriconazole and fluconazole on the pharmacokinetics of almonertinib in rats by UPLC–MS/MS.  BIOMEDICAL CHROMATOGRAPHY,  37  (1): (e5525).  [PMID:36241418]
10. Tao Ye, Shushu Yuan, Yu Kong, Huiqun Yang, Hongming Wei, Yuhe Zhang, Hangqi Jin, Qingxia Yu, Jiaming Liu, Songfang Chen, Jing Sun.  (2022)  Effect of Probiotic Fungi against Cognitive Impairment in Mice via Regulation of the Fungal Microbiota–Gut–Brain Axis.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (29): (9026–9038).  [PMID:35833673]
11. Ma Yinzheng, Wang Yuanxiao, Zhou Xia, Yang Heng, Zhang Huixin, Chen Wenhan, Zhang Haiying, Zhang Yunxia, He Xiaowen.  (2021)  The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains.  Scientific Reports,  11  (1): (1-10).  [PMID:34608206]

Solution Calculators