Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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E129360-1g | 1g | In stock | $77.90 | |
E129360-5g | 5g | In stock | $240.90 | |
E129360-10g | 10g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $432.90 | |
E129360-25g | 25g | In stock | $973.90 | |
E129360-100g | 100g | In stock | $3,504.90 | |
E129360-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $15,769.90 |
Triazole antifungal agent. Cytochrome P450 inhibitor.
Synonyms | Elazor | Flucostat | Fungata | Triflucan | difluconazole | Syscan | Cryptal | 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol | Biozole | Biozolene | Zonal | Fluconazol | Diflucan | Flucoral | Pritenzol | Baten | Loitin | Forcan | Fluconazol |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Fluconazole is a triazole broad-spectrum antifungal agent which is effective against Candida spp., cryptococcus neoformans and dermatophytes. Fluconazole is an inhibitor of CYP2C19, CYP2C9 and CYP3A4.Triazole antifungal agent. Cytochrome P450 inhibitor (I |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Action Type | INHIBITOR |
Mechanism of action | Cytochrome P450 51 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Introduction Fluconazole is used to treat adult neutropenic patients with invasive candidiasis (IC). Application Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants. |
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IUPAC Name | 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol |
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INCHI | InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 |
InChi Key | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O |
Isomeric SMILES | C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O |
WGK Germany | 3 |
RTECS | XZ4810000 |
PubChem CID | 3365 |
Molecular Weight | 306.27 |
Reaxy-Rn | 4269710 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2428178 | Certificate of Analysis | Jun 18, 2024 | E129360 |
F2428221 | Certificate of Analysis | Jun 18, 2024 | E129360 |
F2428222 | Certificate of Analysis | Jun 18, 2024 | E129360 |
F2428223 | Certificate of Analysis | Jun 18, 2024 | E129360 |
D2423019 | Certificate of Analysis | Apr 26, 2024 | E129360 |
B2216357 | Certificate of Analysis | Dec 12, 2023 | E129360 |
B2216363 | Certificate of Analysis | Dec 12, 2023 | E129360 |
B2216391 | Certificate of Analysis | Dec 12, 2023 | E129360 |
B2216406 | Certificate of Analysis | Dec 12, 2023 | E129360 |
B2216511 | Certificate of Analysis | Dec 12, 2023 | E129360 |
F2105267 | Certificate of Analysis | Mar 14, 2023 | E129360 |
A2107199 | Certificate of Analysis | Oct 24, 2022 | E129360 |
F2008081 | Certificate of Analysis | Apr 26, 2022 | E129360 |
G2311076 | Certificate of Analysis | Dec 21, 2021 | E129360 |
H2316118 | Certificate of Analysis | Dec 21, 2021 | E129360 |
Solubility | Soluble in water (<1 mg/ml at 25 °C), ethanol (61 mg/ml at 25 °C), and DMSO (61 mg/ml at 25 °C). |
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Melt Point(°C) | 138.0-142.0℃ |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H371:May cause damage to organs H362:May cause harm to breast-fed children |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P308+P316:IF exposed or concerned: Get emergency medical help immediately. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | XZ4810000 |
Reaxy-Rn | 4269710 |
Merck Index | 4122 |
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1. Yinzheng Ma, Jinlei Sui, Yan Wang, Wanying Sun, Guohui Yi, Jinyan Wu, Shi Qiu, Lili Wang, Aihua Zhang, Xiaowen He. (2023) RNA-Seq-Based Transcriptomics and GC–MS Quantitative Analysis Reveal Antifungal Mechanisms of Essential Oil of Clausena lansium (Lour.) Skeels Seeds against Candida albicans. MOLECULES, 28 (24): (8052). [PMID:38138542] |
2. Khaing Zar Myint, Zhuoyu Zhou, Qiandai Shi, Junming Chen, Xinyu Dong, Yongmei Xia. (2023) Stevia Polyphenols, Their Antimicrobial and Anti-Inflammatory Properties, and Inhibitory Effect on Digestive Enzymes. MOLECULES, 28 (22): (7572). [PMID:38005293] |
3. Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li, Ting Liu. (2023) Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen. FOOD AND CHEMICAL TOXICOLOGY, 180 (28): (114011). [PMID:37660943] |
4. Xinying Sui, Xinyu Cheng, Zhaodi Li, Yonghong Wang, Zhenpeng Zhang, Ruyue Yan, Lei Chang, Yanchang Li, Ping Xu, Changzhu Duan. (2023) Quantitative proteomics revealed the transition of ergosterol biosynthesis and drug transporters processes during the development of fungal fluconazole resistance. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1866 (194953). [PMID:37307946] |
5. Meng Wang, Yanwen Zhou, Zhaohui Wang. (2023) Unearth the ultrapotent intrinsic fungicidal efficacy of the surface-piercing CuFeSe2-PVP nano-blade. CHEMICAL ENGINEERING JOURNAL, 464 (142603). [PMID:] |
6. Mingzhu Zhu, Chen He, Jinchuan Zhou, Yi Li, Lilin Qian, Jiaozhen Zhang, Yanan Qiao, Wenqiang Chang, Hongxiang Lou. (2023) Liverwort-Derived Metabolites Retard Endophyte Growth and Inspire Antifungal Application. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (12): (4863–4875). [PMID:36919252] |
7. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv. (2023) Biotransformation of Penindolone, an Influenza A Virus Inhibitor. MOLECULES, 28 (3): (1479). [PMID:36771146] |
8. Yu Wang, Zejun Pei, Zaixiang Lou, Hongxin Wang. (2022) Evaluation of Anti-Biofilm Capability of Cordycepin Against Candida albicans. Infection and Drug Resistance, [PMID:33574683] |
9. Yuhao Fu, Ying Li, Yinling Ma, Xueru He, Xuejiao Xun, Yanjun Cui, Liju Fan, Zhanjun Dong. (2022) Effects of voriconazole and fluconazole on the pharmacokinetics of almonertinib in rats by UPLC–MS/MS. BIOMEDICAL CHROMATOGRAPHY, 37 (1): (e5525). [PMID:36241418] |
10. Tao Ye, Shushu Yuan, Yu Kong, Huiqun Yang, Hongming Wei, Yuhe Zhang, Hangqi Jin, Qingxia Yu, Jiaming Liu, Songfang Chen, Jing Sun. (2022) Effect of Probiotic Fungi against Cognitive Impairment in Mice via Regulation of the Fungal Microbiota–Gut–Brain Axis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (29): (9026–9038). [PMID:35833673] |
11. Ma Yinzheng, Wang Yuanxiao, Zhou Xia, Yang Heng, Zhang Huixin, Chen Wenhan, Zhang Haiying, Zhang Yunxia, He Xiaowen. (2021) The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains. Scientific Reports, 11 (1): (1-10). [PMID:34608206] |
1. Yinzheng Ma, Jinlei Sui, Yan Wang, Wanying Sun, Guohui Yi, Jinyan Wu, Shi Qiu, Lili Wang, Aihua Zhang, Xiaowen He. (2023) RNA-Seq-Based Transcriptomics and GC–MS Quantitative Analysis Reveal Antifungal Mechanisms of Essential Oil of Clausena lansium (Lour.) Skeels Seeds against Candida albicans. MOLECULES, 28 (24): (8052). [PMID:38138542] |
2. Khaing Zar Myint, Zhuoyu Zhou, Qiandai Shi, Junming Chen, Xinyu Dong, Yongmei Xia. (2023) Stevia Polyphenols, Their Antimicrobial and Anti-Inflammatory Properties, and Inhibitory Effect on Digestive Enzymes. MOLECULES, 28 (22): (7572). [PMID:38005293] |
3. Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li, Ting Liu. (2023) Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen. FOOD AND CHEMICAL TOXICOLOGY, 180 (28): (114011). [PMID:37660943] |
4. Xinying Sui, Xinyu Cheng, Zhaodi Li, Yonghong Wang, Zhenpeng Zhang, Ruyue Yan, Lei Chang, Yanchang Li, Ping Xu, Changzhu Duan. (2023) Quantitative proteomics revealed the transition of ergosterol biosynthesis and drug transporters processes during the development of fungal fluconazole resistance. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1866 (194953). [PMID:37307946] |
5. Meng Wang, Yanwen Zhou, Zhaohui Wang. (2023) Unearth the ultrapotent intrinsic fungicidal efficacy of the surface-piercing CuFeSe2-PVP nano-blade. CHEMICAL ENGINEERING JOURNAL, 464 (142603). [PMID:] |
6. Mingzhu Zhu, Chen He, Jinchuan Zhou, Yi Li, Lilin Qian, Jiaozhen Zhang, Yanan Qiao, Wenqiang Chang, Hongxiang Lou. (2023) Liverwort-Derived Metabolites Retard Endophyte Growth and Inspire Antifungal Application. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (12): (4863–4875). [PMID:36919252] |
7. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv. (2023) Biotransformation of Penindolone, an Influenza A Virus Inhibitor. MOLECULES, 28 (3): (1479). [PMID:36771146] |
8. Yu Wang, Zejun Pei, Zaixiang Lou, Hongxin Wang. (2022) Evaluation of Anti-Biofilm Capability of Cordycepin Against Candida albicans. Infection and Drug Resistance, [PMID:33574683] |
9. Yuhao Fu, Ying Li, Yinling Ma, Xueru He, Xuejiao Xun, Yanjun Cui, Liju Fan, Zhanjun Dong. (2022) Effects of voriconazole and fluconazole on the pharmacokinetics of almonertinib in rats by UPLC–MS/MS. BIOMEDICAL CHROMATOGRAPHY, 37 (1): (e5525). [PMID:36241418] |
10. Tao Ye, Shushu Yuan, Yu Kong, Huiqun Yang, Hongming Wei, Yuhe Zhang, Hangqi Jin, Qingxia Yu, Jiaming Liu, Songfang Chen, Jing Sun. (2022) Effect of Probiotic Fungi against Cognitive Impairment in Mice via Regulation of the Fungal Microbiota–Gut–Brain Axis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (29): (9026–9038). [PMID:35833673] |
11. Ma Yinzheng, Wang Yuanxiao, Zhou Xia, Yang Heng, Zhang Huixin, Chen Wenhan, Zhang Haiying, Zhang Yunxia, He Xiaowen. (2021) The influence of the chemical composition of essential oils of Clausena lansium seeds on the growth of Candida strains. Scientific Reports, 11 (1): (1-10). [PMID:34608206] |