Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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F610353-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,334.90 | |
F610353-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,001.90 | |
F610353-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $19.90 | |
F610353-250mg | 250mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $31.90 | |
F610353-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $71.90 | |
F610353-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $285.90 |
Synonyms | 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ANTAGONIST, CHANNEL BLOCKER |
Mechanism of action | Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3;Antagonist of D 2 receptor |
Product Description | Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects。 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine |
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INCHI | InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+ |
InChi Key | SMANXXCATUTDDT-QPJJXVBHSA-N |
Canonical SMILES | C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F |
Isomeric SMILES | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F |
Alternate CAS | 52468-60-7,40218-96-0,30484-77-6 (di-hydrochloride) |
PubChem CID | 941361 |
MeSH Entry Terms | Dihydrochloride, Flunarizine;Flunarizin;Flunarizine;Flunarizine Dihydrochloride;Flunarizine Hydrochloride;Hydrochloride, Flunarizine;R 14950;R-14950;R14950;Sibelium |
Molecular Weight | 404.5 |
PubChem CID | 941361 |
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CAS Registry No. | 52468-60-7 |
ChEMBL Ligand | CHEMBL30008 |
BindingDB Ligand | 50017702 |
DrugBank Ligand | DB04841 |
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1. Teive HA, Troiano AR, Germiniani FM, Werneck LC. (2004) Flunarizine and cinnarizine-induced parkinsonism: a historical and clinical analysis.. Parkinsonism Relat Disord, 10 (4): (243-5). [PMID:15120099] [10.1021/op500134e] |
2. Shen Y, Qi X, Wan T. (2020) The Treatment of Vestibular Migraine: A Narrative Review.. Ann Indian Acad Neurol, 23 (5): (602-607). [PMID:33623258] [10.1021/op500134e] |
3. Olesen J. (1986) Role of calcium entry blockers in the prophylaxis of migraine.. Eur Neurol, 25 Suppl 1 (13): (72-9). [PMID:3530775] [10.1021/op500134e] |
4. Capellà D, Laporte JR, Castel JM, Tristán C, Cos A, Morales-Olivas FJ. (1988) Parkinsonism, tremor, and depression induced by cinnarizine and flunarizine.. BMJ, 297 (6650): (722-3). [PMID:3147743] [10.1021/op500134e] |
5. von Brevern M, Lempert T. (2020) Vestibular Migraine: Treatment and Prognosis.. Semin Neurol, 40 (1): (83-86). [PMID:31887753] [10.1021/op500134e] |
6. Holmes B, Brogden RN, Heel RC, Speight TM, Avery GS. (1984) Flunarizine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use.. Drugs, 27 (1): (6-44). [PMID:6141044] [10.1021/op500134e] |
7. Amery WK. (1983) Flunarizine, a calcium channel blocker: a new prophylactic drug in migraine.. Headache, 23 (2): (70-4). [PMID:6343298] [10.1021/op500134e] |
8. Kariya S, Isozaki S, Masubuchi Y, Suzuki T, Narimatsu S. (1995) Possible pharmacokinetic and pharmacodynamic factors affecting parkinsonism inducement by cinnarizine and flunarizine.. Biochem Pharmacol, 50 (10): (1645-50). [PMID:7503767] [10.1021/op500134e] |