Flunarizine - 98%, high purity , CAS No.52468-60-7, Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3;Antagonist of D 2 receptor

Item Number

F610353

Grouped product items
SKU	Size	Availability	Price
F610353-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
F610353-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90
F610353-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$19.90
F610353-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$31.90
F610353-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$71.90
F610353-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$285.90

View related series

Basic Description

Synonyms	flunarizine\|Sibelium\|52468-60-7\|1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine\|Flunarizinum\|Flunarizina\|Flunarizinum [INN-Latin]\|Flunarizina [INN-Spanish]\|Narzine\|40218-96-0\|UNII-R7PLA2DM0J\|R7PLA2DM0J\|(Z)-Flunarizine\|EINECS 257-937-5\|(E)-1-(Bis(4-fluo
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST, CHANNEL BLOCKER
Mechanism of action	Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3;Antagonist of D 2 receptor
Product Description	Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects。

Names and Identifiers

IUPAC Name	1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
INCHI	InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+
InChi Key	SMANXXCATUTDDT-QPJJXVBHSA-N
Canonical SMILES	C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
Isomeric SMILES	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
Alternate CAS	52468-60-7,40218-96-0,30484-77-6 (di-hydrochloride)
PubChem CID	941361
MeSH Entry Terms	Dihydrochloride, Flunarizine;Flunarizin;Flunarizine;Flunarizine Dihydrochloride;Flunarizine Hydrochloride;Hydrochloride, Flunarizine;R 14950;R-14950;R14950;Sibelium
Molecular Weight	404.5

PubChem CID

CAS Registry No.

ChEMBL Ligand

BindingDB Ligand

DrugBank Ligand

References

1. Teive HA, Troiano AR, Germiniani FM, Werneck LC. (2004) Flunarizine and cinnarizine-induced parkinsonism: a historical and clinical analysis.. Parkinsonism Relat Disord, 10 (4): (243-5). [PMID:15120099]
2. Shen Y, Qi X, Wan T. (2020) The Treatment of Vestibular Migraine: A Narrative Review.. Ann Indian Acad Neurol, 23 (5): (602-607). [PMID:33623258]
3. Olesen J. (1986) Role of calcium entry blockers in the prophylaxis of migraine.. Eur Neurol, 25 Suppl 1 (3): (72-9). [PMID:3530775]
4. Capellà D, Laporte JR, Castel JM, Tristán C, Cos A, Morales-Olivas FJ. (1988) Parkinsonism, tremor, and depression induced by cinnarizine and flunarizine.. BMJ, 297 (6650): (722-3). [PMID:3147743]
5. von Brevern M, Lempert T. (2020) Vestibular Migraine: Treatment and Prognosis.. Semin Neurol, 40 (1): (83-86). [PMID:31887753]
6. Holmes B, Brogden RN, Heel RC, Speight TM, Avery GS. (1984) Flunarizine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use.. Drugs, 27 (1): (6-44). [PMID:6141044]
7. Amery WK. (1983) Flunarizine, a calcium channel blocker: a new prophylactic drug in migraine.. Headache, 23 (2): (70-4). [PMID:6343298]
8. Kariya S, Isozaki S, Masubuchi Y, Suzuki T, Narimatsu S. (1995) Possible pharmacokinetic and pharmacodynamic factors affecting parkinsonism inducement by cinnarizine and flunarizine.. Biochem Pharmacol, 50 (10): (1645-50). [PMID:7503767]

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description