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Nuclear Receptors
Retinoid X receptors
Fluorobexarotene - ≥97%(HPLC), high purity , CAS No.1190848-23-7, Agonist of Retinoid X receptor-α

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Fluorobexarotene - ≥97%(HPLC), high purity , CAS No.1190848-23-7, Agonist of Retinoid X receptor-α

Moligand™
≥97%(HPLC)

CAS#: 1190848-23-7
Formula: C₂₄H₂₇FO₂
Molecular Weight: 366.47
PubChem CID: 25195496

Item Number

F288070

Grouped product items
SKU	Size	Availability	Price	Qty
F288070-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$939.90

RXR agonist

View related series

Retinoid X receptor-α Agonist

Basic Description

Synonyms	Fluorobexarotene\|1190848-23-7\|2-fluoro-4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid\|GTPL8904\|CHEMBL4524642\|SCHEMBL14816550\|DTXSID001021433\|NSC783327\|AKOS024457960\|NSC-783327\|HY-108525\|CS-0029093\|Q27077689\|F9994-0680\|2-fluoro
Specifications & Purity	≥97%(HPLC)
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of Retinoid X receptor-α

Associated Targets

RXRA Tclin Retinoic acid receptor RXR-alpha 2 Activities

Discover Target: RXRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-fluoro-4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid
INCHI	InChI=1S/C24H27FO2/c1-14-11-19-20(24(5,6)10-9-23(19,3)4)13-18(14)15(2)16-7-8-17(22(26)27)21(25)12-16/h7-8,11-13H,2,9-10H2,1,3-6H3,(H,26,27)
InChi Key	LWKAWHRSPCHMPJ-UHFFFAOYSA-N
Canonical SMILES	CC1=CC2=C(C=C1C(=C)C3=CC(=C(C=C3)C(=O)O)F)C(CCC2(C)C)(C)C
Isomeric SMILES	CC1=CC2=C(C=C1C(=C)C3=CC(=C(C=C3)C(=O)O)F)C(CCC2(C)C)(C)C
PubChem CID	25195496
Molecular Weight	366.47

Database links

PubChem CID	25195496
CAS Registry No.	1190848-23-7

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 36.65, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.16, Max Conc. mM: 25

References

1. Wagner CE, Jurutka PW, Marshall PA, Groy TL, van der Vaart A, Ziller JW, Furmick JK, Graeber ME, Matro E, Miguel BV et al.. (2009) Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).. J Med Chem, 52 (19): (5950-66). [PMID:19791803]

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