Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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F684869-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $29.90 | |
F684869-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $99.90 | |
F684869-25g | 25g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $359.90 | |
F684869-100g | 100g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $999.90 |
Specifications & Purity | Moligand™, ≥95% |
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Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ANTAGONIST, CHANNEL BLOCKER, GATING INHIBITOR, INHIBITOR |
Mechanism of action | Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2B receptor;Antagonist of 5-HT 2C receptor;Antagonist of 5-HT 6 receptor;Channel blocker of CaCC;Gating inhibitor of K ir3.2;Gating inhibitor of K v3.1;Inhibitor of Plasma membrane monoamine transporter;In |
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IUPAC Name | N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine |
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INCHI | InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 |
InChi Key | RTHCYVBBDHJXIQ-UHFFFAOYSA-N |
Canonical SMILES | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F |
Isomeric SMILES | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F |
PubChem CID | 3386 |
Molecular Weight | 309.33 |
Enter Lot Number to search for COA:
Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
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Pictogram(s) | GHS06, GHS08, GHS09, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H318:Causes serious eye damage H336:May cause drowsiness or dizziness H410:Very toxic to aquatic life with long lasting effects H330:Fatal if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
Class | 8 |
1. Jiao-Zhao Yan, Guang-Xiang Li, Si-Rui Sun, Lin-Yu Cui, Yong-Yu Yin, Yun-Feng Li. (2024) A rate-limiting step in antidepressants onset: Excitation of glutamatergic pyramidal neurons in medial prefrontal cortex of rodents. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 130 (110911). [PMID:38065287] |
2. Yiyang Du, Tingxu Yan, Bo Wu, Bosai He, Ying Jia. (2024) Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway. JOURNAL OF ETHNOPHARMACOLOGY, 319 (10): (117190). [PMID:37739105] |
3. Yu Hui, Shao Shumin, Xu Junnan, Guo Haibiao, Zhong Zhangfeng, Xu Jiangping. (2022) Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin reuptake in mice. Chinese Medicine, 17 (1): (1-20). [PMID:35668445] |
4. Qianqian Shang, Huajing Liu, Hang Mei, Chuixiu Huang, Xiantao Shen. (2022) Multi-extraction system with identical supported semi-liquid membrane: Enhanced stability for coextraction of acidic and basic drugs. TALANTA, 246 (123485). [PMID:35462249] |
5. Tiantian Wang, Ruihe Zheng, Song Sun. (2022) Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 599 (1). [PMID:35158201] |
6. Ruiqin Zhu, Hang Mei, Huajing Liu, Changbao Hong, Xiantao Shen, Chuixiu Huang. (2022) Successive liquid-phase microextraction of acidic and basic analytes. ANALYTICA CHIMICA ACTA, 1192 (339335). [PMID:35057942] |
1. Jiao-Zhao Yan, Guang-Xiang Li, Si-Rui Sun, Lin-Yu Cui, Yong-Yu Yin, Yun-Feng Li. (2024) A rate-limiting step in antidepressants onset: Excitation of glutamatergic pyramidal neurons in medial prefrontal cortex of rodents. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 130 (110911). [PMID:38065287] |
2. Yiyang Du, Tingxu Yan, Bo Wu, Bosai He, Ying Jia. (2024) Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway. JOURNAL OF ETHNOPHARMACOLOGY, 319 (10): (117190). [PMID:37739105] |
3. Yu Hui, Shao Shumin, Xu Junnan, Guo Haibiao, Zhong Zhangfeng, Xu Jiangping. (2022) Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin reuptake in mice. Chinese Medicine, 17 (1): (1-20). [PMID:35668445] |
4. Qianqian Shang, Huajing Liu, Hang Mei, Chuixiu Huang, Xiantao Shen. (2022) Multi-extraction system with identical supported semi-liquid membrane: Enhanced stability for coextraction of acidic and basic drugs. TALANTA, 246 (123485). [PMID:35462249] |
5. Tiantian Wang, Ruihe Zheng, Song Sun. (2022) Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 599 (1). [PMID:35158201] |
6. Ruiqin Zhu, Hang Mei, Huajing Liu, Changbao Hong, Xiantao Shen, Chuixiu Huang. (2022) Successive liquid-phase microextraction of acidic and basic analytes. ANALYTICA CHIMICA ACTA, 1192 (339335). [PMID:35057942] |