Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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F131623-1g | 1g | In stock | $66.90 | |
F131623-5g | 5g | In stock | $200.90 | |
F131623-25g | 25g | In stock | $902.90 | |
F131623-100g | 100g | In stock | $3,247.90 | |
F131623-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $14,612.90 |
5-HT reuptake inhibitor
Synonyms | Flunil | Fluoxetine (as hydrochloride) | Fluxen | Pragmaten | Prozac 20 | CPD000058452 | Fluoxil | Fluox-Puren | HY-B0102A | Opera_ID_1538 | SMR000058452 | Fluxil | HMS1569H03 | CHEBI:145458 | Deproxin | EINECS 260-101-2 | MLS002222264 | Nopres | Fluoxeti |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Fluoxetine is an ST (5-hydroxytryptamine/serotonin/5-HT reuptake) inhibitor. This is a racemic mixture and both R and S enantiomers which are reported to inhibit 5-HT uptake in synaptosomal preparations of rat cerebral cortex. Additionally, Fluoxetine is |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Action Type | INHIBITOR |
Mechanism of action | Serotonin transporter inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Fluoxetine is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression. application: Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. It is used to treat major depressive disorder, bulimia nervosa (an eating disorder) obsessive-compulsive disorder, panic disorder and premenstrual dysphoric disorder (PMDD). product description: Fluoxetine hydrochloride is a psychotropic agent and one of the initial members of the anti-depressant class of drugs known as selective serotonin-reuptake inhibitors (SSRIs). |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488183615 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488183615 |
IUPAC Name | N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine;hydrochloride |
INCHI | InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H |
InChi Key | GIYXAJPCNFJEHY-UHFFFAOYSA-N |
Canonical SMILES | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl |
Isomeric SMILES | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl |
WGK Germany | 3 |
RTECS | UI4050000 |
PubChem CID | 62857 |
Molecular Weight | 345.79 |
Reaxy-Rn | 6759273 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
C2324684 | Certificate of Analysis | Jan 02, 2023 | F131623 |
C2324766 | Certificate of Analysis | Jan 02, 2023 | F131623 |
C2324770 | Certificate of Analysis | Jan 02, 2023 | F131623 |
C2324771 | Certificate of Analysis | Jan 02, 2023 | F131623 |
C2324774 | Certificate of Analysis | Jan 02, 2023 | F131623 |
C2324779 | Certificate of Analysis | Jan 02, 2023 | F131623 |
C2324782 | Certificate of Analysis | Jan 02, 2023 | F131623 |
C2324834 | Certificate of Analysis | Jan 02, 2023 | F131623 |
I2222530 | Certificate of Analysis | Nov 13, 2021 | F131623 |
Solubility | Soluble in water (4 mg/mL), DMSO (>5 mg/mL), acetone, acetonitrile, chloroform, and methanol. |
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Melt Point(°C) | 159 °C |
Pictogram(s) | GHS09, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H302:Harmful if swallowed H318:Causes serious eye damage H400:Very toxic to aquatic life |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. |
WGK Germany | 3 |
RTECS | UI4050000 |
Reaxy-Rn | 6759273 |
1. Lin Sheng, Yumeng Wei, Chao Pi, Ju Cheng, Zhilian Su, Yuanyuan Wang, Tao Chen, Jie Wen, Yuxun Wei, Jingwen Ma, Jia Tang, Huiyang Liu, Zerong Liu, Hongping Shen, Ying Zuo, Wenwu Zheng, Ling Zhao. (2023) Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect. International Journal of Nanomedicine, [PMID:38162571] [10.2147/IJN.S430769] |
2. Zhou Can, Zhou Yiming, Liang Yu, Chen Lijuan, Liu Li, Wei Fang, Li Guolin. (2023) Fluoxetine Promotes Longevity via Reactive Oxygen Species in Caenorhabditis elegans. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 79 (1): [PMID:37708096] [10.1093/gerona/glad220] |
3. Shangmin Yu, Xinying Wang, Linlin Lv, Tongyan Liu, Qingxiang Guan. (2023) Borneol-modified PEGylated graphene oxide as a nanocarrier for brain-targeted delivery of ginsenoside Rg1 against depression. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 643 (123284). [PMID:37527732] [10.1016/j.ijpharm.2023.123284] |
4. Weiwei Wang, Xin Li, Qiuhui Qian, Jin Yan, Haishan Huang, Xuedong Wang, Huili Wang. (2023) Mechanistic exploration on neurodevelopmental toxicity induced by upregulation of alkbh5 targeted by triclosan exposure to larval zebrafish. JOURNAL OF HAZARDOUS MATERIALS, 457 (131831). [PMID:37320907] [10.1016/j.jhazmat.2023.131831] |
5. Jiaqi Xie, Yihong Li, Yulu Liang, Hongqian Kui, Can Wang, Jianmei Huang. (2023) Integration of non-targeted metabolomics with network pharmacology deciphers the anxiolytic mechanisms of Platycladi Semen extracts in CUMS mice. JOURNAL OF ETHNOPHARMACOLOGY, 315 (116571). [PMID:37201666] [10.1016/j.jep.2023.116571] |
6. Jiang Chuan, Wang Hua, Qi Jiaying, Li Jinghan, He Qianqian, Wang Chaonan, Gao Yonggang. (2022) Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop. METABOLIC BRAIN DISEASE, 37 (8): (2883-2901). [PMID:36181653] [10.1007/s11011-022-01081-7] |
7. Zhuo Rengong, Cheng Xiaoling, Luo Lili, Yang Luying, Zhao Yun, Zhou Yu, Peng Lu, Jin Xin, Cui Lishan, Liu Feng, Yang Lichao. (2022) Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice. PHARMACOLOGY, 107 (5-6): (281-289). [PMID:35325888] [10.1159/000520990] |
8. Chai Yuhui, Cai Yawen, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua. (2022) Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway. Frontiers in Pharmacology, 13 [PMID:35496273] [10.3389/fphar.2022.812362] |
9. Yiwei Liu, Xiaopeng Hu, Yide Xia, Faqiong Zhao, Baizhao Zeng. (2022) A novel ratiometric electrochemical sensor based on dual-monomer molecularly imprinted polymer and Pt/Co3O4 for sensitive detection of chlorpromazine hydrochloride. ANALYTICA CHIMICA ACTA, 1190 (339245). [PMID:34857150] [10.1016/j.aca.2021.339245] |
10. Shangmin Yu, Shan Liu, Ning Wang, Di Yu, Meng Qin, Ji Wu, Qingxiang Guan. (2021) Novel insights into antidepressant mechanism of Kai Xin San formula: Inhibiting NLRP3 inflammasome activation by promoting autophagy. PHYTOMEDICINE, 93 (153792). [PMID:34735906] [10.1016/j.phymed.2021.153792] |
11. Jiang Ning, Wang Haixia, Huang Hong, Lv Jingwei, Zeng Guirong, Wang Qiong, Bao Yu, Chen Ying, Liu Xinmin. (2021) The Antidepressant-Like Effects of Shen Yuan in a Chronic Unpredictable Mild Stress Rat Model. Frontiers in Psychiatry, 12 [PMID:33584387] [10.3389/fpsyt.2021.622204] |
12. Hang Mei, Huajing Liu, Qianqian Shang, Ying Dong, Stig Pedersen-Bjergaard, Chuixiu Huang, Xiantao Shen. (2021) Organic-solvent-free electromembrane extraction based on semi-interpenetrating polymer networks. GREEN CHEMISTRY, 23 (4): (1782-1793). [PMID:] [10.1039/D1GC00148E] |
13. Yunfeng Zhou, Mingzhu Yan, Ruile Pan, Zhi Wang, Xue Tao, Chenchen Li, Tianji Xia, Xinmin Liu, Qi Chang. (2021) Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation. JOURNAL OF ETHNOPHARMACOLOGY, 265 (113317). [PMID:32861821] [10.1016/j.jep.2020.113317] |
14. Rui Bai, Weifu Yan, Yong Xiao, Siqi Wang, Xiaochun Tian, Junpeng Li, Xiaofeng Xiao, Xiaoquan Lu, Feng Zhao. (2020) Acceleration of peroxymonosulfate decomposition by a magnetic MoS2/CuFe2O4 heterogeneous catalyst for rapid degradation of fluoxetine. CHEMICAL ENGINEERING JOURNAL, 397 (125501). [PMID:] [10.1016/j.cej.2020.125501] |
15. Yunfeng Zhou, Xue Tao, Zhi Wang, Li Feng, Lisha Wang, Xinmin Liu, Ruile Pan, Yonghong Liao, Qi Chang. (2019) Hippocampus Metabolic Disturbance and Autophagy Deficiency in Olfactory Bulbectomized Rats and the Modulatory Effect of Fluoxetine. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20 (17): (4282). [PMID:31480539] [10.3390/ijms20174282] |
16. Yun-Feng Zhou, Li Feng, Xin-Min Liu, Xue Tao, Li-Sha Wang, Meng-Di Zhang, Zhi Wang, Shan-Guang Chen, Qi Chang. (2019) Urinary metabolic disturbance in the olfactory bulbectomized rats and the modulatory effects of fluoxetine. LIFE SCIENCES, 234 (116751). [PMID:31415771] [10.1016/j.lfs.2019.116751] |
17. Libin Wan, Bin Lin, Ruiqin Zhu, Chuixiu Huang, Stig Pedersen-Bjergaard, Xiantao Shen. (2019) Liquid-Phase Microextraction or Electromembrane Extraction?. ANALYTICAL CHEMISTRY, 91 (13): (8267–8273). [PMID:31141346] [10.1021/acs.analchem.9b00946] |
18. Li Yang, Liu Jing, Liu Xu, Su Cun-Jin, Zhang Qi-Lin, Wang Zhi-Hong, Cao Lei-Fang, Guo Xue-Yan, Huang Ya, Luo Weifeng, Liu Tong. (2019) Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain. Neuroscience Bulletin, 35 (4): (661-672). [PMID:30900142] [10.1007/s12264-019-00367-8] |
19. Shujie Zhu, Shaowei Lei, Sisi Zhou, Lisha Jin, Su Zeng, Huidi Jiang, Hui Zhou. (2019) Luteolin shows antidepressant-like effect by inhibiting and downregulating plasma membrane monoamine transporter (PMAT, Slc29a4). Journal of Functional Foods, 54 (440). [PMID:] [10.1016/j.jff.2019.01.048] |
20. Chang-An Geng, Tong-Hua Yang, Xiao-Yan Huang, Yun-Bao Ma, Xue-Mei Zhang, Ji-Jun Chen. (2019) Antidepressant potential of Uncaria rhynchophylla and its active flavanol, catechin, targeting melatonin receptors. JOURNAL OF ETHNOPHARMACOLOGY, 232 (39). [PMID:30543912] [10.1016/j.jep.2018.12.013] |
1. Lin Sheng, Yumeng Wei, Chao Pi, Ju Cheng, Zhilian Su, Yuanyuan Wang, Tao Chen, Jie Wen, Yuxun Wei, Jingwen Ma, Jia Tang, Huiyang Liu, Zerong Liu, Hongping Shen, Ying Zuo, Wenwu Zheng, Ling Zhao. (2023) Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect. International Journal of Nanomedicine, [PMID:38162571] [10.2147/IJN.S430769] |
2. Zhou Can, Zhou Yiming, Liang Yu, Chen Lijuan, Liu Li, Wei Fang, Li Guolin. (2023) Fluoxetine Promotes Longevity via Reactive Oxygen Species in Caenorhabditis elegans. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 79 (1): [PMID:37708096] [10.1093/gerona/glad220] |
3. Shangmin Yu, Xinying Wang, Linlin Lv, Tongyan Liu, Qingxiang Guan. (2023) Borneol-modified PEGylated graphene oxide as a nanocarrier for brain-targeted delivery of ginsenoside Rg1 against depression. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 643 (123284). [PMID:37527732] [10.1016/j.ijpharm.2023.123284] |
4. Weiwei Wang, Xin Li, Qiuhui Qian, Jin Yan, Haishan Huang, Xuedong Wang, Huili Wang. (2023) Mechanistic exploration on neurodevelopmental toxicity induced by upregulation of alkbh5 targeted by triclosan exposure to larval zebrafish. JOURNAL OF HAZARDOUS MATERIALS, 457 (131831). [PMID:37320907] [10.1016/j.jhazmat.2023.131831] |
5. Jiaqi Xie, Yihong Li, Yulu Liang, Hongqian Kui, Can Wang, Jianmei Huang. (2023) Integration of non-targeted metabolomics with network pharmacology deciphers the anxiolytic mechanisms of Platycladi Semen extracts in CUMS mice. JOURNAL OF ETHNOPHARMACOLOGY, 315 (116571). [PMID:37201666] [10.1016/j.jep.2023.116571] |
6. Jiang Chuan, Wang Hua, Qi Jiaying, Li Jinghan, He Qianqian, Wang Chaonan, Gao Yonggang. (2022) Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop. METABOLIC BRAIN DISEASE, 37 (8): (2883-2901). [PMID:36181653] [10.1007/s11011-022-01081-7] |
7. Zhuo Rengong, Cheng Xiaoling, Luo Lili, Yang Luying, Zhao Yun, Zhou Yu, Peng Lu, Jin Xin, Cui Lishan, Liu Feng, Yang Lichao. (2022) Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice. PHARMACOLOGY, 107 (5-6): (281-289). [PMID:35325888] [10.1159/000520990] |
8. Chai Yuhui, Cai Yawen, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua. (2022) Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway. Frontiers in Pharmacology, 13 [PMID:35496273] [10.3389/fphar.2022.812362] |
9. Yiwei Liu, Xiaopeng Hu, Yide Xia, Faqiong Zhao, Baizhao Zeng. (2022) A novel ratiometric electrochemical sensor based on dual-monomer molecularly imprinted polymer and Pt/Co3O4 for sensitive detection of chlorpromazine hydrochloride. ANALYTICA CHIMICA ACTA, 1190 (339245). [PMID:34857150] [10.1016/j.aca.2021.339245] |
10. Shangmin Yu, Shan Liu, Ning Wang, Di Yu, Meng Qin, Ji Wu, Qingxiang Guan. (2021) Novel insights into antidepressant mechanism of Kai Xin San formula: Inhibiting NLRP3 inflammasome activation by promoting autophagy. PHYTOMEDICINE, 93 (153792). [PMID:34735906] [10.1016/j.phymed.2021.153792] |
11. Jiang Ning, Wang Haixia, Huang Hong, Lv Jingwei, Zeng Guirong, Wang Qiong, Bao Yu, Chen Ying, Liu Xinmin. (2021) The Antidepressant-Like Effects of Shen Yuan in a Chronic Unpredictable Mild Stress Rat Model. Frontiers in Psychiatry, 12 [PMID:33584387] [10.3389/fpsyt.2021.622204] |
12. Hang Mei, Huajing Liu, Qianqian Shang, Ying Dong, Stig Pedersen-Bjergaard, Chuixiu Huang, Xiantao Shen. (2021) Organic-solvent-free electromembrane extraction based on semi-interpenetrating polymer networks. GREEN CHEMISTRY, 23 (4): (1782-1793). [PMID:] [10.1039/D1GC00148E] |
13. Yunfeng Zhou, Mingzhu Yan, Ruile Pan, Zhi Wang, Xue Tao, Chenchen Li, Tianji Xia, Xinmin Liu, Qi Chang. (2021) Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation. JOURNAL OF ETHNOPHARMACOLOGY, 265 (113317). [PMID:32861821] [10.1016/j.jep.2020.113317] |
14. Rui Bai, Weifu Yan, Yong Xiao, Siqi Wang, Xiaochun Tian, Junpeng Li, Xiaofeng Xiao, Xiaoquan Lu, Feng Zhao. (2020) Acceleration of peroxymonosulfate decomposition by a magnetic MoS2/CuFe2O4 heterogeneous catalyst for rapid degradation of fluoxetine. CHEMICAL ENGINEERING JOURNAL, 397 (125501). [PMID:] [10.1016/j.cej.2020.125501] |
15. Yunfeng Zhou, Xue Tao, Zhi Wang, Li Feng, Lisha Wang, Xinmin Liu, Ruile Pan, Yonghong Liao, Qi Chang. (2019) Hippocampus Metabolic Disturbance and Autophagy Deficiency in Olfactory Bulbectomized Rats and the Modulatory Effect of Fluoxetine. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20 (17): (4282). [PMID:31480539] [10.3390/ijms20174282] |
16. Yun-Feng Zhou, Li Feng, Xin-Min Liu, Xue Tao, Li-Sha Wang, Meng-Di Zhang, Zhi Wang, Shan-Guang Chen, Qi Chang. (2019) Urinary metabolic disturbance in the olfactory bulbectomized rats and the modulatory effects of fluoxetine. LIFE SCIENCES, 234 (116751). [PMID:31415771] [10.1016/j.lfs.2019.116751] |
17. Libin Wan, Bin Lin, Ruiqin Zhu, Chuixiu Huang, Stig Pedersen-Bjergaard, Xiantao Shen. (2019) Liquid-Phase Microextraction or Electromembrane Extraction?. ANALYTICAL CHEMISTRY, 91 (13): (8267–8273). [PMID:31141346] [10.1021/acs.analchem.9b00946] |
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