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Fluperlapine - ≥95%, high purity , CAS No.67121-76-0, Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor
an agonist of the serotonin 5-HT6/5-HT7 receptors
Basic Description Synonyms GTPL279 | HMS2090H12 | 3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine | L000256 | Tox21_111780_1 | BPBio1_001099 | FLUPERLAPINE [MART.] | HMS2052M07 | FLUPERLAPINE | PDSP1_000472 | DTXCID0026123 | NB-106689 | SCHEMBL142558 | C10967 | NCGC001 Specifications & Purity Moligand™, ≥95% Storage Temp Room temperature Shipped In Normal Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor Product Description Fluperlapine is an agonist of the SR-6/SR-7 (serotonin 5-HT|6|/5-HT|7|receptors). Agonism of the 5-HT|6|/5-HT|7|receptors by Fluperlapine has been correlated to sedative effects. Fluperlapine is described to function similarly to Clozapine , and Fluperlapine is also described to be relatively resistant to chemical and biochemical oxidation as compared to Clozapine.
Product Properties pKa pKₐ: 7.46 (Predicted) Ki Data Serotonin 2a receptor: Ki= 3.8 nM (Rattus norvegicus); Serotonin 2b receptor: Ki= 3.8 nM (Rattus norvegicus); Serotonin 2c receptor: Ki= 3.8 nM (Rattus norvegicus); Muscarinic acetylcholine receptor: Ki= 25 nM (Rattus norvegicus)
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3-fluoro-6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine INCHI InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3 InChi Key OBWGMKKHCLHVIE-UHFFFAOYSA-N Canonical SMILES CN1CCN(CC1)C2=NC3=C(CC4=CC=CC=C42)C=CC(=C3)F Isomeric SMILES CN1CCN(CC1)C2=NC3=C(CC4=CC=CC=C42)C=CC(=C3)F PubChem CID 49381 Molecular Weight 309.4
Chemical and Physical Properties Solubility Soluble in DMSO (10 mg/ml), and ethanol (20 mg/ml). Refractive Index n20D1.64 (Predicted) Boil Point(°C) ~438.74° C at 760 mmHg (Predicted) Melt Point(°C) ~18-20° C
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