The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Fluperlapine - ≥95%, high purity , CAS No.67121-76-0, Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor
an agonist of the serotonin 5-HT6/5-HT7 receptors
Basic Description Synonyms GTPL279 | HMS2090H12 | 3-Fluoro-6-(4-methyl-piperazin-1-yl)-11H-dibenzo[b,e]azepine | L000256 | Tox21_111780_1 | BPBio1_001099 | FLUPERLAPINE [MART.] | HMS2052M07 | FLUPERLAPINE | PDSP1_000472 | DTXCID0026123 | NB-106689 | SCHEMBL142558 | C10967 | NCGC001 Specifications & Purity Moligand™, ≥95% Storage Temp Room temperature Shipped In Normal Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor Product Description Fluperlapine is an agonist of the SR-6/SR-7 (serotonin 5-HT|6|/5-HT|7|receptors). Agonism of the 5-HT|6|/5-HT|7|receptors by Fluperlapine has been correlated to sedative effects. Fluperlapine is described to function similarly to Clozapine , and Fluperlapine is also described to be relatively resistant to chemical and biochemical oxidation as compared to Clozapine.
Product Properties pKa pKₐ: 7.46 (Predicted) Ki Data Serotonin 2a receptor: Ki= 3.8 nM (Rattus norvegicus); Serotonin 2b receptor: Ki= 3.8 nM (Rattus norvegicus); Serotonin 2c receptor: Ki= 3.8 nM (Rattus norvegicus); Muscarinic acetylcholine receptor: Ki= 25 nM (Rattus norvegicus)
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 3-fluoro-6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine INCHI InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3 InChi Key OBWGMKKHCLHVIE-UHFFFAOYSA-N Canonical SMILES CN1CCN(CC1)C2=NC3=C(CC4=CC=CC=C42)C=CC(=C3)F Isomeric SMILES CN1CCN(CC1)C2=NC3=C(CC4=CC=CC=C42)C=CC(=C3)F PubChem CID 49381 Molecular Weight 309.4
Chemical and Physical Properties Solubility Soluble in DMSO (10 mg/ml), and ethanol (20 mg/ml). Refractive Index n20D1.64 (Predicted) Boil Point(°C) ~438.74° C at 760 mmHg (Predicted) Melt Point(°C) ~18-20° C
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
