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Fluperlapine - ≥95%, high purity , CAS No.67121-76-0, Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor

Moligand™
≥95%

CAS#: 67121-76-0
Formula: C₁₉H₂₀FN₃
Molecular Weight: 309.4
PubChem CID: 49381

Item Number

F336050

Grouped product items
SKU	Size	Availability	Price
F336050-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$47.90
F336050-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$215.90
F336050-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$380.90

an agonist of the serotonin 5-HT6/5-HT7 receptors

View related series

5-HT6 receptor Antagonist 5-HT7 receptor Antagonist

Basic Description

Synonyms	FLUPERLAPINE\|67121-76-0\|Fluperlapina\|Fluperlapine [INN]\|Fluperlapinum\|Fluperlapinum [INN-Latin]\|Fluperlapina [INN-Spanish]\|3-fluoro-6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine\|CHEMBL63756\|CHEBI:5122\|DTXSID2046123\|C10967\|EWG253M961\|3-Fluoro-6-(4-
Specifications & Purity	Moligand™, ≥95%
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor
Product Description	Fluperlapine is an agonist of the SR-6/SR-7 (serotonin 5-HT\|6\|/5-HT\|7\|receptors). Agonism of the 5-HT\|6\|/5-HT\|7\|receptors by Fluperlapine has been correlated to sedative effects. Fluperlapine is described to function similarly to Clozapine , and Fluperlapine is also described to be relatively resistant to chemical and biochemical oxidation as compared to Clozapine.

pKa

pKₐ: 7.46 (Predicted)

Ki Data

Serotonin 2a receptor: Ki= 3.8 nM (Rattus norvegicus); Serotonin 2b receptor: Ki= 3.8 nM (Rattus norvegicus); Serotonin 2c receptor: Ki= 3.8 nM (Rattus norvegicus); Muscarinic acetylcholine receptor: Ki= 25 nM (Rattus norvegicus)

Associated Targets

DRD1 Tclin D(1A) dopamine receptor 0 Activities

Discover Target: DRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

Discover Target: DRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 0 Activities

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM5 Tclin Muscarinic acetylcholine receptor M5 0 Activities

Discover Target: CHRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

Discover Target: HTR2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR7 Tclin 5-hydroxytryptamine receptor 7 2 Activities

Discover Target: HTR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR6 Tchem 5-hydroxytryptamine receptor 6 1 Activities

Discover Target: HTR6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-fluoro-6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine
INCHI	InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3
InChi Key	OBWGMKKHCLHVIE-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2=NC3=C(CC4=CC=CC=C42)C=CC(=C3)F
Isomeric SMILES	CN1CCN(CC1)C2=NC3=C(CC4=CC=CC=C42)C=CC(=C3)F
PubChem CID	49381
Molecular Weight	309.4

PubChem CID

ChEMBL Ligand

BindingDB Ligand

Wikipedia

CAS Registry No.

GPCRdb Ligand

Solubility

Soluble in DMSO (10 mg/ml), and ethanol (20 mg/ml).

Refractive Index

n20D1.64 (Predicted)

Boil Point(°C)

~438.74° C at 760 mmHg (Predicted)

Melt Point(°C)

~18-20° C

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Fluperlapine - ≥95%, high purity , CAS No.67121-76-0, Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor

Basic Description

Product Properties