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Flutamide - >98.0%(GC), high purity , CAS No.13311-84-7, Antagonist of Androgen receptor
Non-steroidal, competitive androgen receptor antagonist
Basic Description Synonyms flutamide|13311-84-7|Niftolide|Eulexin|Niftholide|Sch 13521|niftolid|NFBA|2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide|Drogenil|Cebatrol, veterinary|Flutamidum|Flutamida|Flutamin|4'-Nitro-3'-trifluoromethylisobutyranilide|Sch-13521|Ham's F-12 Specifications & Purity >98.0%(GC) Shipped In Normal Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of Androgen receptor Product Description Flutamide is an androgen receptor inhibitor with chemopreventive properties against bladder and prostate carcinogenesis. Flutamide inhibits the expression of testosterone regulated transforming growth factor β-1 (TGF-β1).
Names and Identifiers Pubchem Sid 488179766 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488179766 IUPAC Name 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide INCHI InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17) InChi Key MKXKFYHWDHIYRV-UHFFFAOYSA-N Canonical SMILES CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F Isomeric SMILES CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F WGK Germany 3 RTECS UG5700000 PubChem CID 3397 Molecular Weight 276.22 Reaxy-Rn 2157663
Chemical and Physical Properties Solubility Insoluble in water; Very soluble in Acetone,Methanol; Soluble in Chloroform,Ether Sensitivity light sensitive Melt Point(°C) 112 °C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Warning Hazard Statements H373: Causes damage to organs through prolonged or repeated exposure
H302: Harmful if swallowed
H312: Harmful in contact with skin
H332: Harmful if inhaled
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P271: Use only outdoors or in a well-ventilated area.
P270: Do not eat, drink or smoke when using this product.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
P317: Get emergency medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 RTECS UG5700000 Reaxy-Rn 2157663 Merck Index 4208
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