Flutamide - >98.0%(GC), high purity , CAS No.13311-84-7, Antagonist of Androgen receptor

Item Number
F156754
Grouped product items
SKUSizeAvailabilityPrice Qty
F156754-5g
5g
In stock
$109.90
F156754-25g
25g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$495.90
F156754-100g
100g
In stock
$1,782.90

Non-steroidal, competitive androgen receptor antagonist

Basic Description

Synonyms76W6J0943E | BRN 2157663 | Eulexin (TN) | SCHEMBL12932289 | 4'-Nitro-3'-trifluoromethylisobutyranilide | FLUTAMIDE (USP MONOGRAPH) | FLUTAMIDE [ORANGE BOOK] | Flutamidum (INN-Latin) | KBioSS_001690 | .alpha.,.alpha.-Trifluoro-2-methyl-4'-nitro-m-propionot
Specifications & PurityMoligand™, ≥98%(GC)
Biochemical and Physiological MechanismsFlutamide is a non-steroidal anti-androgen.Non-steroidal, competitive androgen receptor antagonist. Limits the uptake of testosterone by the prostate.
Shipped InNormal
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of Androgen receptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Flutamide is an androgen receptor inhibitor with chemopreventive properties against bladder and prostate carcinogenesis. Flutamide inhibits the expression of testosterone regulated transforming growth factor β-1 (TGF-β1).
An androgen receptor antagonist

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AR Tclin Androgen receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AADAC Tchem Arylacetamide deacetylase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488179766
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179766
IUPAC Name 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
INCHI InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
InChi Key MKXKFYHWDHIYRV-UHFFFAOYSA-N
Canonical SMILES CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F
Isomeric SMILES CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F
WGK Germany 3
RTECS UG5700000
PubChem CID 3397
Molecular Weight 276.22
Reaxy-Rn 2157663

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
L2010085Certificate of AnalysisSep 10, 2024 F156754
L2010084Certificate of AnalysisSep 10, 2024 F156754
D2009003Certificate of AnalysisJan 16, 2024 F156754
D2313329Certificate of AnalysisApr 25, 2023 F156754
L22151039Certificate of AnalysisNov 29, 2022 F156754
L22151041Certificate of AnalysisNov 29, 2022 F156754
L2215959Certificate of AnalysisNov 29, 2022 F156754
L2215995Certificate of AnalysisNov 29, 2022 F156754
L2215996Certificate of AnalysisNov 29, 2022 F156754

Chemical and Physical Properties

SolubilityInsoluble in water; Very soluble in Acetone,Methanol; Soluble in Chloroform,Ether
Sensitivitylight sensitive
Melt Point(°C)112 °C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Warning
Hazard Statements

H373:Causes damage to organs through prolonged or repeated exposure

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P317:Get emergency medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS UG5700000
Reaxy-Rn 2157663
Merck Index 4208

Related Documents

Citations of This Product

1. Jiao Sha, Kaibo Hu, Tingting Li, Zidan Cao, Yameng Wan, Renren Sun, Haixia He, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren.  (2021)  Solubility determination, model correlation, solvent effect, molecular simulation and thermodynamic properties of flutamide in eleven pure solvents at different temperatures.  JOURNAL OF MOLECULAR LIQUIDS,  336  (115559).  [PMID:] [10.1016/j.molliq.2021.115559]

References

1. Jiao Sha, Kaibo Hu, Tingting Li, Zidan Cao, Yameng Wan, Renren Sun, Haixia He, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren.  (2021)  Solubility determination, model correlation, solvent effect, molecular simulation and thermodynamic properties of flutamide in eleven pure solvents at different temperatures.  JOURNAL OF MOLECULAR LIQUIDS,  336  (115559).  [PMID:] [10.1016/j.molliq.2021.115559]

Solution Calculators