Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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F156754-5g | 5g | In stock | $109.90 | |
F156754-25g | 25g | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $495.90 | |
F156754-100g | 100g | In stock | $1,782.90 |
Non-steroidal, competitive androgen receptor antagonist
Synonyms | 76W6J0943E | BRN 2157663 | Eulexin (TN) | SCHEMBL12932289 | 4'-Nitro-3'-trifluoromethylisobutyranilide | FLUTAMIDE (USP MONOGRAPH) | FLUTAMIDE [ORANGE BOOK] | Flutamidum (INN-Latin) | KBioSS_001690 | .alpha.,.alpha.-Trifluoro-2-methyl-4'-nitro-m-propionot |
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Specifications & Purity | Moligand™, ≥98%(GC) |
Biochemical and Physiological Mechanisms | Flutamide is a non-steroidal anti-androgen.Non-steroidal, competitive androgen receptor antagonist. Limits the uptake of testosterone by the prostate. |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of Androgen receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Flutamide is an androgen receptor inhibitor with chemopreventive properties against bladder and prostate carcinogenesis. Flutamide inhibits the expression of testosterone regulated transforming growth factor β-1 (TGF-β1). |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Pubchem Sid | 488179766 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179766 |
IUPAC Name | 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
INCHI | InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17) |
InChi Key | MKXKFYHWDHIYRV-UHFFFAOYSA-N |
Canonical SMILES | CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F |
Isomeric SMILES | CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F |
WGK Germany | 3 |
RTECS | UG5700000 |
PubChem CID | 3397 |
Molecular Weight | 276.22 |
Reaxy-Rn | 2157663 |
ChEMBL Ligand | CHEMBL806 |
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DrugBank Ligand | DB00499 |
PubChem CID | 3397 |
CAS Registry No. | 13311-84-7 |
Wikipedia | Flutamide |
NURSA Ligand | 10.1621/IM1B4XSSB8 |
PEP | flutamide |
DrugCentral Ligand | 1223 |
PubChem SID | 488179766 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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L2010085 | Certificate of Analysis | Sep 10, 2024 | F156754 |
L2010084 | Certificate of Analysis | Sep 10, 2024 | F156754 |
D2009003 | Certificate of Analysis | Jan 16, 2024 | F156754 |
D2313329 | Certificate of Analysis | Apr 25, 2023 | F156754 |
L22151039 | Certificate of Analysis | Nov 29, 2022 | F156754 |
L22151041 | Certificate of Analysis | Nov 29, 2022 | F156754 |
L2215959 | Certificate of Analysis | Nov 29, 2022 | F156754 |
L2215995 | Certificate of Analysis | Nov 29, 2022 | F156754 |
L2215996 | Certificate of Analysis | Nov 29, 2022 | F156754 |
Solubility | Insoluble in water; Very soluble in Acetone,Methanol; Soluble in Chloroform,Ether |
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Sensitivity | light sensitive |
Melt Point(°C) | 112 °C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | UG5700000 |
Reaxy-Rn | 2157663 |
Merck Index | 4208 |
1. Jiao Sha, Kaibo Hu, Tingting Li, Zidan Cao, Yameng Wan, Renren Sun, Haixia He, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren. (2021) Solubility determination, model correlation, solvent effect, molecular simulation and thermodynamic properties of flutamide in eleven pure solvents at different temperatures. JOURNAL OF MOLECULAR LIQUIDS, 336 (115559). [PMID:] [10.1016/j.molliq.2021.115559] |
1. Jiao Sha, Kaibo Hu, Tingting Li, Zidan Cao, Yameng Wan, Renren Sun, Haixia He, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren. (2021) Solubility determination, model correlation, solvent effect, molecular simulation and thermodynamic properties of flutamide in eleven pure solvents at different temperatures. JOURNAL OF MOLECULAR LIQUIDS, 336 (115559). [PMID:] [10.1016/j.molliq.2021.115559] |