Grouped product items

SKU

Size

Availability

Price

Qty

F337893-25mg

25mg

Available within 4-8 weeks(?)

$209.90

F337893-100mg

100mg

Available within 4-8 weeks(?)

$752.90

Basic Description

Synonyms	fluvoxamine\|54739-18-3\|Fluvoxamina\|Fluvoxaminum\|Fluvoxaminum [INN-Latin]\|Fluvoxamina [INN-Spanish]\|UNII-O4L1XPO44W\|O4L1XPO44W\|Fluvoxamine (INN)\|2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine\|CHEBI:5138\|DTXSID2044002\|N06AB08
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of SERT;sigma non-opioid intracellular receptor 1
Product Description	Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) and an activator of Sigma Receptor.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR1 Tclin Cannabinoid receptor 1 0 Activities

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CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

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EYA3 Tbio Eyes absent homolog 3 0 Activities

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AVPR1A Tclin Vasopressin V1a receptor 0 Activities

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ABCB1 Tchem Multidrug resistance protein 1 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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HRH1 Tclin Histamine H1 receptor 0 Activities

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter 2 Activities

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SLC6A4 Tclin Sodium-dependent serotonin transporter 4 Activities

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TMEM97 Tchem Sigma intracellular receptor 2 0 Activities

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SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 2 Activities

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PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

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PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

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CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

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DRD3 Tclin D(3) dopamine receptor 0 Activities

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CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

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HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2A Tclin Adenosine receptor A2a 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADRB1 Tclin Beta-1 adrenergic receptor 0 Activities

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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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AR Tclin Androgen receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2C Tclin 5-hydroxytryptamine receptor 2C 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MLNR Tchem Motilin receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine
INCHI	InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+
InChi Key	CJOFXWAVKWHTFT-XSFVSMFZSA-N
Canonical SMILES	COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F
Isomeric SMILES	COCCCC/C(=N\OCCN)/C1=CC=C(C=C1)C(F)(F)F
PubChem CID	5324346
Molecular Weight	318.33

Database links

DrugBank Ligand	DB00176
PubChem CID	5324346
CAS Registry No.	54739-18-3
ChEMBL Ligand	CHEMBL814
Wikipedia	Fluvoxamine
ChEBI	CHEBI:5138
RCSB PDB Ligand	FVX
PEP	fluvoxamine
Reactome Reaction	R-HSA-9679780
Reactome Drug	R-ALL-9679783
DrugCentral Ligand	1230

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
C2222554	Certificate of Analysis	Feb 22, 2022	F337893
C2222564	Certificate of Analysis	Feb 22, 2022	F337893

Chemical and Physical Properties

Solubility	Soluble in Chloroform, Dichloromethane, and Petroleum Ether

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS09, GHS05, GHS07
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H335:May cause respiratory irritation H331:Toxic if inhaled H302:Harmful if swallowed H318:Causes serious eye damage H332:Harmful if inhaled H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.

References

1. Cobos EJ, Entrena JM, Nieto FR, Cendán CM, Del Pozo E. (2008) Pharmacology and therapeutic potential of sigma(1) receptor ligands.. Curr Neuropharmacol, 6 (4): (344-66). [PMID:19587856]
2. Yu LF, Zhang HK, Gunosewoyo H, Kozikowski AP. (2012) From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design.. ACS Med Chem Lett, 3 (12): (1054-1058). [PMID:23641311]
3. Hashimoto K. (2015) Activation of sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication.. J Pharmacol Sci, 127 (1): (6-9). [PMID:25704012]
4. Sukhatme VP, Reiersen AM, Vayttaden SJ, Sukhatme VV. (2021) Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19.. Front Pharmacol, 12 (3): (652688). [PMID:33959018]
5. Wu H, Denna TH, Storkersen JN, Gerriets VA. (2019) Beyond a neurotransmitter: The role of serotonin in inflammation and immunity.. Pharmacol Res, 140 (3): (100-114). [PMID:29953943]
6. Costa LHA, Santos BM, Branco LGS. (2020) Can selective serotonin reuptake inhibitors have a neuroprotective effect during COVID-19?. Eur J Pharmacol, 889 (3): (173629). [PMID:33022271]
7. Lenze EJ, Mattar C, Zorumski CF, Stevens A, Schweiger J, Nicol GE, Miller JP, Yang L, Yingling M, Avidan MS et al.. (2020) Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial.. JAMA, 324 (22): (2292-2300). [PMID:33180097]
8. Schoenichen C, Bode C, Duerschmied D. (2019) Role of platelet serotonin in innate immune cell recruitment.. Front Biosci (Landmark Ed), 24 (3): (514-526). [PMID:30468670]
9. Rosen DA, Seki SM, Fernández-Castañeda A, Beiter RM, Eccles JD, Woodfolk JA, Gaultier A. (2019) Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.. Sci Transl Med, 11 (478): (589-97). [PMID:30728287]

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SKU	Size	Availability	Price	Qty
F337893-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$209.90
F337893-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$752.90

Fluvoxamine - 98%, high purity , CAS No.54739-18-3, Inhibitor of SERT;sigma non-opioid intracellular receptor 1