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Fmoc-Leu-OH - 98%, high purity , CAS No.35661-60-0, Agonist of Peroxisome proliferator-activated receptor-γ

1 Citations
Item Number
F100808
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F100808-5g
5g
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F100808-25g
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100g
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$349.90
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500g
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Increases intracellular Ca2+levels

View related series
Peroxisome proliferator-activated receptor-γ Agonist

Basic Description

SynonymsMaybridge1_005562 | MFCD00037133 | HMS557E18 | N-(Fluoren-9-ylmethoxycarbonyl)-L-leucine | NSC-334290 | AC-24092 | AKOS010398974 | Fmoc-Leu-OH | Z1123720065 | KF18F70UF3 | N-((9H-FLUOREN-9-YLMETHOXY)CARBONYL)-L-LEUCINE, (-)- | NCGC00255677-01 | BDBM115093
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsAnti-inflammatory agent; increases intracellular Ca2+levels.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of Peroxisome proliferator-activated receptor-γ

Associated Targets(Human)

NTSR1 Tchem Neurotensin receptor type 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPARG Tclin Peroxisome proliferator-activated receptor gamma (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AHR Tclin Aryl hydrocarbon receptor (1071 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H2 Tchem LXR-beta (3841 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRCA1 Tchem Breast cancer type 1 susceptibility protein (15908 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTNS Tbio Cystinosin (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC17A5 Tbio Sialin (56 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid
INCHI InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m0/s1
InChi Key CBPJQFCAFFNICX-IBGZPJMESA-N
Canonical SMILES CC(C)CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Isomeric SMILES CC(C)C[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
WGK Germany 3
PubChem CID 1549133
Molecular Weight 353.41
Beilstein 2178254
Reaxy-Rn 2178254

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
C1912133Certificate of AnalysisDec 14, 2022 F100808
H2401033Certificate of AnalysisJun 16, 2022 F100808
I2215178Certificate of AnalysisJun 16, 2022 F100808
I2215179Certificate of AnalysisJun 16, 2022 F100808
I2215193Certificate of AnalysisJun 16, 2022 F100808
I2215194Certificate of AnalysisJun 16, 2022 F100808

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 35.34, Max Conc. mM: 100 with gentle warming
Specific Rotation[α]-25 ° (C=1, DMF)
Melt Point(°C)153-157°C

Safety and Hazards(GHS)

WGK Germany 3
Reaxy-Rn 2178254

Related Documents

 SDS

 Specification Sheet

Citations of This Product

1. Jianchao Zhang, Caibing Ma, Yongjun Yu, Chaowei Liu, Lijing Fang, Hai Rao.  (2023)  Single amino acid-based PROTACs trigger degradation of the oncogenic kinase BCR-ABL in chronic myeloid leukemia (CML).  JOURNAL OF BIOLOGICAL CHEMISTRY,    (104994).  [PMID:37392851]

References

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2. G Cheng,V Castelletto,C M Moulton,G E Newby,I W Hamley.  (2010-01-16)  Hydrogelation and self-assembly of Fmoc-tripeptides: unexpected influence of sequence on self-assembled fibril structure, and hydrogel modulus and anisotropy..  Langmuir : the ACS journal of surfaces and colloids,  26  ((7)): (4990-4998).  [PMID:20073495]
3. Soo Min Cho,Hyunjin Vincent Kim,Sejin Lee,Hye Yun Kim,Woong Kim,Tae Song Kim,Dong Jin Kim,YoungSoo Kim.  (2014-10-28)  Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model..  Scientific reports,  4  (6777-6777).  [PMID:25345439]
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8. Stefan Eissler,Markus Kley,Dirk Bächle,Günther Loidl,Thomas Meier,Daniel Samson.  (2017-06-22)  Substitution determination of Fmoc-substituted resins at different wavelengths..  Journal of peptide science : an official publication of the European Peptide Society,  23  ((10)): (757-762).  [PMID:28635051]
9. Markus Beck Erlach,Joerg Koehler,Edson Crusca,Claudia E Munte,Masatsune Kainosho,Werner Kremer,Hans Robert Kalbitzer.  (2017-09-16)  Pressure dependence of side chain.  Journal of biomolecular NMR,  69  ((2)): (53-67).  [PMID:28913741]
10. Zdenek Kukacka,Marius Iurascu,Loredana Lupu,Hendrik Rusche,Mary Murphy,Lorenzo Altamore,Fabio Borri,Stefan Maeser,Anna Maria Papini,Julia Hennermann,Michael Przybylski.  (2018-02-24)  Antibody Epitope of Human α-Galactosidase\u2005A Revealed by Affinity Mass Spectrometry: A Basis for Reversing Immunoreactivity in Enzyme Replacement Therapy of Fabry Disease..  ChemMedChem,  13  ((9)): (909-915).  [PMID:29473701]
11. Fan Gao,Chi Zhang,Wen-Xiu Qiu,Xue Dong,Di-Wei Zheng,Wei Wu,Xian-Zheng Zhang.  (2018-08-22)  PD-1 Blockade for Improving the Antitumor Efficiency of Polymer-Doxorubicin Nanoprodrug..  Small (Weinheim an der Bergstrasse, Germany),  14  ((37)): (e1802403-e1802403).  [PMID:30129176]
12. Hong Cheng,Gui-Ling Fan,Jing-Hao Fan,Rong-Rong Zheng,Lin-Ping Zhao,Ping Yuan,Xiao-Ya Zhao,Xi-Yong Yu,Shi-Ying Li.  (2018-12-24)  A Self-Delivery Chimeric Peptide for Photodynamic Therapy Amplified Immunotherapy..  Macromolecular bioscience,  19  ((4)): (e1800410-e1800410).  [PMID:30576082]
13. Vibeke Miller Breinholt,Caroline E Rasmussen,Per Holse Mygind,Mads Kjelgaard-Hansen,Frank Faltinger,Ana Bernhard,Joachim Zettler,Ulrich Hersel.  (2019-06-27)  TransCon CNP, a Sustained-Release C-Type Natriuretic Peptide Prodrug, a Potentially Safe and Efficacious New Therapeutic Modality for the Treatment of Comorbidities Associated with Fibroblast Growth Factor Receptor 3-Related Skeletal Dysplasias..  The Journal of pharmacology and experimental therapeutics,  370  ((3)): (459-471).  [PMID:31235532]
14. Michał Padjasek,Maciej Maciejczyk,Michał Nowakowski,Olga Kerber,Maciej Pyrka,Wiktor Koźmiński,Artur Krężel.  (2019-12-18)  Metal Exchange in the Interprotein ZnII -Binding Site of the Rad50 Hook Domain: Structural Insights into CdII -Induced DNA-Repair Inhibition..  Chemistry (Weinheim an der Bergstrasse, Germany),  26  ((15)): (3297-3313).  [PMID:31846102]
15. Jingwen Song,Chengqian Yuan,Tifeng Jiao,Ruirui Xing,Mengyao Yang,Dave J Adams,Xuehai Yan.  (2020-01-30)  Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly..  Small (Weinheim an der Bergstrasse, Germany),  16  ((8)): (e1907309-e1907309).  [PMID:31994844]
16. Yun Song,Lisbeth Dagil,Louise Fairall,Naomi Robertson,Mingxuan Wu,T J Ragan,Christos G Savva,Almutasem Saleh,Nobuhiro Morone,Micha B A Kunze,Andrew G Jamieson,Philip A Cole,D Flemming Hansen,John W R Schwabe.  (2020-02-27)  Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex..  Cell reports,  30  ((8)): (2699-2711).  [PMID:32101746]
17. M J Miller,S Chotinaruemol,H Sadowska-Krowikca,X J Zhang,J A McIntyre,D A Clark.  (1993-07-01)  Guinea pig ileitis is attenuated by the leumedin N-(fluorenyl-9- methoxycarbonyl)-leucine (NPC 15199)..  The Journal of pharmacology and experimental therapeutics,  266  ((1)): (468-472).  [PMID:8392562]
18. C R Jan,C C Yu,J K Huang.  (2000-06-17)  NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells..  The Chinese journal of physiology,  43  ((1)): (29-33).  [PMID:10857466]
19. Zhimou Yang,Keming Xu,Ling Wang,Hongwei Gu,Heng Wei,Mingjie Zhang,Bing Xu.  (2005-09-02)  Self-assembly of small molecules affords multifunctional supramolecular hydrogels for topically treating simulated uranium wounds..  Chemical communications (Cambridge, England),  (35)  ((35)): (4414-4416).  [PMID:16136235]
20. Weidang Wu,Yan Dong,Jing Gao,Min Gong,Xing Zhang,Weiling Kong,Yazhuo Li,Yong Zeng,Duanyun Si,Zihong Wei,Xiaoyan Ci,Lixin Jiang,Wei Li,Quansheng Li,Xiulin Yi,Changxiao Liu.  (2015-04-14)  Aspartate-modified doxorubicin on its N-terminal increases drug accumulation in LAT1-overexpressing tumors..  Cancer science,  106  ((6)): (747-756).  [PMID:25867020]
21. Franziska Thomas,Ai Niitsu,Alain Oregioni,Gail J Bartlett,Derek N Woolfson.  (2017-11-23)  Conformational Dynamics of Asparagine at Coiled-Coil Interfaces..  Biochemistry,  56  ((50)): (6544-6554).  [PMID:29166010]
22. Marius Brehm,Stefan Heissler,Sergii Afonin,Pavel A Levkin.  (2020-01-28)  Nanomolar Synthesis in Droplet Microarrays with UV-Triggered On-Chip Cell Screening..  Small (Weinheim an der Bergstrasse, Germany),  16  ((10)): (e1905971-e1905971).  [PMID:31985878]
23. Jianchao Zhang, Caibing Ma, Yongjun Yu, Chaowei Liu, Lijing Fang, Hai Rao.  (2023)  Single amino acid-based PROTACs trigger degradation of the oncogenic kinase BCR-ABL in chronic myeloid leukemia (CML).  JOURNAL OF BIOLOGICAL CHEMISTRY,    (104994).  [PMID:37392851]

Solution Calculators

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