Fmoc-Leu-OH - 98%, high purity , CAS No.35661-60-0, Agonist of Peroxisome proliferator-activated receptor-γ

Item Number
F100808
Grouped product items
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F100808-5g
5g
In stock
$23.90
F100808-10g
10g
Available within 8-12 weeks(?)
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$43.90
F100808-25g
25g
In stock
$97.90
F100808-100g
100g
In stock
$349.90
F100808-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,574.90

Increases intracellular Ca2+levels

Basic Description

SynonymsMaybridge1_005562 | MFCD00037133 | HMS557E18 | N-(Fluoren-9-ylmethoxycarbonyl)-L-leucine | NSC-334290 | AC-24092 | AKOS010398974 | Fmoc-Leu-OH | Z1123720065 | KF18F70UF3 | N-((9H-FLUOREN-9-YLMETHOXY)CARBONYL)-L-LEUCINE, (-)- | NCGC00255677-01 | BDBM115093
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsAnti-inflammatory agent; increases intracellular Ca2+levels.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of Peroxisome proliferator-activated receptor-γ

Associated Targets(Human)

NTSR1 Tchem Neurotensin receptor type 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPARG Tclin Peroxisome proliferator-activated receptor gamma (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AHR Tclin Aryl hydrocarbon receptor (1071 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H2 Tchem LXR-beta (3841 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRCA1 Tchem Breast cancer type 1 susceptibility protein (15908 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTNS Tbio Cystinosin (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid
INCHI InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m0/s1
InChi Key CBPJQFCAFFNICX-IBGZPJMESA-N
Canonical SMILES CC(C)CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Isomeric SMILES CC(C)C[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
WGK Germany 3
PubChem CID 1549133
Molecular Weight 353.41
Beilstein 2178254
Reaxy-Rn 2178254

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
C1912133Certificate of AnalysisDec 14, 2022 F100808
H2401033Certificate of AnalysisJun 16, 2022 F100808
I2215178Certificate of AnalysisJun 16, 2022 F100808
I2215179Certificate of AnalysisJun 16, 2022 F100808
I2215193Certificate of AnalysisJun 16, 2022 F100808
I2215194Certificate of AnalysisJun 16, 2022 F100808
I2423655Certificate of AnalysisJun 19, 2021 F100808

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 35.34, Max Conc. mM: 100 with gentle warming
Specific Rotation[α]-25 ° (C=1, DMF)
Melt Point(°C)153-157°C

Safety and Hazards(GHS)

WGK Germany 3
Reaxy-Rn 2178254

Related Documents

Citations of This Product

1. Jianchao Zhang, Caibing Ma, Yongjun Yu, Chaowei Liu, Lijing Fang, Hai Rao.  (2023)  Single amino acid-based PROTACs trigger degradation of the oncogenic kinase BCR-ABL in chronic myeloid leukemia (CML).  JOURNAL OF BIOLOGICAL CHEMISTRY,    (104994).  [PMID:37392851] [10.1016/j.jbc.2023.104994]
2. Xianlin Xu, Guodong Zhao, Hang Wang, Xiaojie Li, Xi Feng, Bowen Cheng, Lei Shi, Weimin Kang, Xupin Zhuang, Yan Yin.  (2019)  Bio-inspired amino-acid-functionalized cellulose whiskers incorporated into sulfonated polysulfone for proton exchange membrane.  JOURNAL OF POWER SOURCES,  409  (123).  [PMID:] [10.1016/j.jpowsour.2018.11.003]

References

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24. Xianlin Xu, Guodong Zhao, Hang Wang, Xiaojie Li, Xi Feng, Bowen Cheng, Lei Shi, Weimin Kang, Xupin Zhuang, Yan Yin.  (2019)  Bio-inspired amino-acid-functionalized cellulose whiskers incorporated into sulfonated polysulfone for proton exchange membrane.  JOURNAL OF POWER SOURCES,  409  (123).  [PMID:] [10.1016/j.jpowsour.2018.11.003]

Solution Calculators