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F105470-5g

In stock

$15.90

F105470-10g

10g

Available within 8-12 weeks(?)

$27.90

F105470-25g

25g

In stock

$45.90

F105470-100g

100g

Available within 4-8 weeks(?)

$164.90

F105470-500g

500g

Available within 4-8 weeks(?)

$738.90

Basic Description

Synonyms	Fmoc-Ile-OH\|Fmoc-L-isoleucine\|71989-23-6\|N-Fmoc-L-isoleucine\|N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucine\|N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine\|MFCD00037125\|(2S,3S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoic acid\|(2S,3S)-2-
Specifications & Purity	≥99%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	application： N-Fmoc-L-isoleucine is an unnatural amino acid used for peptidomimetics. It is also used as a pharmaceutical intermediate

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

Discover Target: HSD17B10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Discover Target: KMT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC17A5 Tbio Sialin 0 Activities

Discover Target: SLC17A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TP53 Tchem Cellular tumor antigen p53 0 Activities

Discover Target: TP53

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S,3S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylpentanoic acid
INCHI	InChI=1S/C21H23NO4/c1-3-13(2)19(20(23)24)22-21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,3,12H2,1-2H3,(H,22,25)(H,23,24)/t13-,19-/m0/s1
InChi Key	QXVFEIPAZSXRGM-DJJJIMSYSA-N
Canonical SMILES	CCC(C)C(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
WGK Germany	3
PubChem CID	2724629
Molecular Weight	353.41
Beilstein	4716717

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
A1917035	Certificate of Analysis	Nov 15, 2022	F105470
C2415108	Certificate of Analysis	Sep 30, 2021	F105470
D2301013	Certificate of Analysis	Sep 30, 2021	F105470
D2301014	Certificate of Analysis	Sep 30, 2021	F105470
H2325072	Certificate of Analysis	Sep 30, 2021	F105470

Chemical and Physical Properties

Solubility	Soluble in methanol (very faint turbidity).
Specific Rotation[α]	-12±1°, c = 1% in DMF
Melt Point(°C)	144-149°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help.
WGK Germany	3

References

1. Chiao-Ting Yen,Tsong-Long Hwang,Yang-Chang Wu,Pei-Wen Hsieh. (2008-12-27) Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents.. European journal of medicinal chemistry, 44 ((5)): (1933-1940). [PMID:19110343]
2. K R Sunil Kumar,Takashi Kamei,Tuyoshi Fukaminato,Nobuyuki Tamaoki. (2014-04-01) Complete ON/OFF photoswitching of the motility of a nanobiomolecular machine.. ACS nano, 8 ((5)): (4157-4165). [PMID:24680285]
3. Moise Ndao,Gil Goobes,Prashant S Emani,Gary P Drobny. (2016-04-05) A REDOR ssNMR Investigation of the Role of an N-Terminus Lysine in R5 Silica Recognition.. Langmuir : the ACS journal of surfaces and colloids, 34 ((29)): (8678-8684). [PMID:27039990]
4. Stefan Eissler,Markus Kley,Dirk Bächle,Günther Loidl,Thomas Meier,Daniel Samson. (2017-06-22) Substitution determination of Fmoc-substituted resins at different wavelengths.. Journal of peptide science : an official publication of the European Peptide Society, 23 ((10)): (757-762). [PMID:28635051]
5. Zdenek Kukacka,Marius Iurascu,Loredana Lupu,Hendrik Rusche,Mary Murphy,Lorenzo Altamore,Fabio Borri,Stefan Maeser,Anna Maria Papini,Julia Hennermann,Michael Przybylski. (2018-02-24) Antibody Epitope of Human α-Galactosidase\u2005A Revealed by Affinity Mass Spectrometry: A Basis for Reversing Immunoreactivity in Enzyme Replacement Therapy of Fabry Disease.. ChemMedChem, 13 ((9)): (909-915). [PMID:29473701]
6. R Ashton Lavoie,Alice di Fazio,R Kevin Blackburn,Michael B Goshe,Ruben G Carbonell,Stefano Menegatti. (2019-04-11) Targeted Capture of Chinese Hamster Ovary Host Cell Proteins: Peptide Ligand Discovery.. International journal of molecular sciences, 20 ((7)): [PMID:30965558]
7. Karthik Nadendla,Bhagyesh R Sarode,Simon H Friedman. (2019-05-24) Hydrophobic Tags for Highly Efficient Light-Activated Protein Release.. Molecular pharmaceutics, 16 ((7)): (2922-2928). [PMID:31117739]
8. Yu-I Hsu,Tetsuji Yamaoka. (2019-08-21) Improved exposure of bioactive peptides to the outermost surface of the polylactic acid nanofiber scaffold.. Journal of biomedical materials research. Part B, Applied biomaterials, 108 ((4)): (1274-1280). [PMID:31429188]
9. R Ashton Lavoie,Alice di Fazio,Taufika Islam Williams,Ruben Carbonell,Stefano Menegatti. (2019-10-28) Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand binding by proteomic analysis.. Biotechnology and bioengineering, 117 ((2)): (438-452). [PMID:31654407]
10. Michał Padjasek,Maciej Maciejczyk,Michał Nowakowski,Olga Kerber,Maciej Pyrka,Wiktor Koźmiński,Artur Krężel. (2019-12-18) Metal Exchange in the Interprotein ZnII -Binding Site of the Rad50 Hook Domain: Structural Insights into CdII -Induced DNA-Repair Inhibition.. Chemistry (Weinheim an der Bergstrasse, Germany), 26 ((15)): (3297-3313). [PMID:31846102]

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Fmoc-lle-OH - 99%, high purity , CAS No.71989-23-6