FN-1501 - 99%, high purity , CAS No.1429515-59-2

Item Number

F650483

• Synonyms: FN-1501 | TQR1001 | CS-0039834 | 4-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-5-carboxamide | 1429515-59-2 | 4-((7H-Pyrrolo (2,3-d)pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H
• Specifications & Purity: ≥99%
• Biochemical and Physiological Mechanisms: FN-1501 is a potent inhibitor of FLT3 and CDK , with IC 50 s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3 , respectively. FN-1501 has anticancer activity.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

FN-1501 is a potent inhibitor of FLT3 and CDK , with IC 50 s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3 , respectively. FN-1501 has anticancer activity.

In Vitro

FN-1501 is a potent inhibitor of FLT3 and CDK, with IC 50 s of 2.47 ± 0.21, 0.85 ± 0.28, 1.96 ± 0.08 and 0.28 ± 0.01 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 shows potent inhibitory activity against several tumor cells, such as MGC803, RS4 11, MCF-7, HCT-116, and NCI-H82, with GI 50 s of 0.37 ± 0.04, 0.05 ± 0.01, 2.84 ± 0.25, 0.09 ± 0.04, 0.11 ± 0.02 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FN-1501 exhibits potent antitumor activity, and shows little cytotoxicity on normal lymphocyte cells, with LD 50 of 185.67 mg/kg in ICR mice. FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and significantly suppresses the growth of tumor in MV4-11-cell-inoculated-xenograft mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Cdk4/cyclin D1 0.85 nM (IC 50 ) CDK6/cyclinD1 1.96 nM (IC 50 ) cdk2/cyclin A 2.47 nM (IC 50 ) FLT3 0.28 nM (IC 50 )