Foretinib (GSK1363089) - ≥98%, high purity , Vascular endothelial growth factor receptor inhibitor, CAS No.849217-64-7, Vascular endothelial growth factor receptor inhibitor

Item Number

F127011

• Synonyms: 81FH7VK1C4 | Foretinib [USAN:INN] | N-(3-FLUORO-4-((6-METHOXY-7-(3-(MORPHOLIN-4-YL)PROPOXY)QUINOLIN-4-YL)OXY) PHENYL)-N'-(4-FLUOROPHENYL)CYCLOPROPANE-1,1-DICARBOXAMIDE | Foretinib | PB27007 | MLS006010302 | Foretinib (USAN/INN) | GSK 1363089 | NCGC0026310
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Potent inhibitor of MET, VEGFR2, Ron and AXL (IC50values are 0.4, 0.9, 3 and 11 nM, respectively). Also potently inhibits Tie-2, Flt-1, Flt-3, Flt-4, KIT, PDGFRαand PDGFRβ. Inhibits migration and invasion of B16F10 melanoma cellsin vitro. Suppresses B16F1
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Vascular endothelial growth factor receptor inhibitor
• Note: 5mg、100mg卖完停产，不再备货

Product Description

Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR
An ATP-competitive inhibitor of tyrosine kinases including Flt-1, Flt-4, Met, and Ron.