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Forodesine - 97%, high purity , CAS No.209799-67-7, Inhibitor of purine nucleoside phosphorylase

Item Number
F175696
Grouped product items
SKUSizeAvailabilityPrice Qty
F175696-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$5,837.90
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View related series
Apoptosis Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog Plasmodium falciparum purine nucleoside phosphorylase Plasmodium falciparum purine nucleoside phosphorylase Inhibitor purine nucleoside phosphorylase Inhibitor

Basic Description

SynonymsGTPL8272 | 7-[(2s,3s,4r,5r)-3,4-dihydroxy-5-hydroxymethyl-2-pyrrolidinyl]-1,5-dihydro-4h-pyrrolo-[3,2-d]-pyrimidin-4-one | Forodesine; Immucillin H | 1,4-dideoxy-4-aza-1-(s)-(9-deazahypoxanthin-9-yl)-d-ribitol | DB06185 | NCGC00091848-01 | NSC 717904 | CH
Specifications & PurityMoligand™, ≥97%
Storage TempRoom temperature
Shipped InNormal
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of purine nucleoside phosphorylase

Associated Targets(Human)

PNP Tclin Purine nucleoside phosphorylase (17 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DCK Tchem Deoxycytidine kinase (530 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pnp Purine nucleoside phosphorylase (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania infantum (5912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
INCHI InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1
InChi Key IWKXDMQDITUYRK-KUBHLMPHSA-N
Canonical SMILES C1=C(C2=C(N1)C(=O)NC=N2)C3C(C(C(N3)CO)O)O
Isomeric SMILES C1=C(C2=C(N1)C(=O)NC=N2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O
PubChem CID 135409409
Molecular Weight 266.2533

Certificates

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Related Documents

 SDS

 Specification Sheet

References

1. Kicska GA, Long L, Hörig H, Fairchild C, Tyler PC, Furneaux RH, Schramm VL, Kaufman HL.  (2001)  Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes..  Proc Natl Acad Sci USA,  98  (8): (4593-8).  [PMID:11287638] [10.1021/op500134e]
2. Kicska GA, Tyler PC, Evans GB, Furneaux RH, Schramm VL, Kim K.  (2002)  Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase..  J Biol Chem,  277  (5): (3226-31).  [PMID:11706018] [10.1021/op500134e]
3. Kicska GA, Tyler PC, Evans GB, Furneaux RH, Kim K, Schramm VL.  (2002)  Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum..  J Biol Chem,  277  (5): (3219-25).  [PMID:11707439] [10.1021/op500134e]
4. Miles RW, Tyler PC, Furneaux RH, Bagdassarian CK, Schramm VL.  (1998)  One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase..  Biochemistry,  37  (24): (8615-21).  [PMID:9628722] [10.1021/op500134e]

Solution Calculators

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