Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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F127328-10mg | 10mg | In stock | $63.90 | |
F127328-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $127.90 | |
F127328-100mg | 100mg | In stock | $177.90 | |
F127328-500mg | 500mg | In stock | $129.90 | |
F127328-1g | 1g | In stock | $1,441.90 | |
F127328-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $6,488.90 |
Adenylyl cyclase activator
Synonyms | BDBM50010261 | MLS001333256 | SMP1_000128 | DTXSID8040484 | NSC 357088 | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho(2,1-b)pyran-1-one 5-acetate | colforsina | NCGC00024996-05 | 1F7A44V6 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo prod |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC), commonly used to raise levels of cAMP in the study and research of cell physiology. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate |
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INCHI | InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1 |
InChi Key | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
Canonical SMILES | CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O |
Isomeric SMILES | CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O |
WGK Germany | 3 |
RTECS | QL6150000 |
PubChem CID | 47936 |
Molecular Weight | 410.5 |
Beilstein | 1692720 |
CAS Registry No. | 66575-29-9 |
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DrugBank Ligand | DB02587 |
Wikipedia | Forskolin |
ChEBI | CHEBI:42471 |
PubChem CID | 47936 |
ChEMBL Ligand | CHEMBL52606 |
RCSB PDB Ligand | FOK |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
B2316338 | Certificate of Analysis | Nov 14, 2024 | F127328 |
J2214299 | Certificate of Analysis | Jul 05, 2024 | F127328 |
F2208133 | Certificate of Analysis | Mar 21, 2024 | F127328 |
K2327382 | Certificate of Analysis | Nov 08, 2023 | F127328 |
K2327374 | Certificate of Analysis | Nov 08, 2023 | F127328 |
K2327373 | Certificate of Analysis | Nov 08, 2023 | F127328 |
K2327231 | Certificate of Analysis | Nov 08, 2023 | F127328 |
K2129685 | Certificate of Analysis | Sep 15, 2023 | F127328 |
K2215085 | Certificate of Analysis | Nov 26, 2022 | F127328 |
C1728032 | Certificate of Analysis | Sep 21, 2022 | F127328 |
C2226626 | Certificate of Analysis | May 24, 2022 | F127328 |
C2223026 | Certificate of Analysis | May 08, 2022 | F127328 |
F2208319 | Certificate of Analysis | Mar 24, 2022 | F127328 |
K2214108 | Certificate of Analysis | Mar 24, 2022 | F127328 |
F2309060 | Certificate of Analysis | Mar 24, 2022 | F127328 |
F2208437 | Certificate of Analysis | Mar 24, 2022 | F127328 |
F2208132 | Certificate of Analysis | Mar 24, 2022 | F127328 |
E2306665 | Certificate of Analysis | Mar 24, 2022 | F127328 |
D2312248 | Certificate of Analysis | Mar 24, 2022 | F127328 |
D2312210 | Certificate of Analysis | Mar 24, 2022 | F127328 |
B2328185 | Certificate of Analysis | Mar 24, 2022 | F127328 |
Solubility | Soluble in DMSO (5 mg/ml), ethanol, methanol, and Chloroform.Insolule in water. |
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Specific Rotation[α] | -17° |
Melt Point(°C) | 224.0 to 228.0°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H312:Harmful in contact with skin |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P362+P364:Take off contaminated clothing and wash it before reuse. P317:Get emergency medical help. |
WGK Germany | 3 |
RTECS | QL6150000 |
Merck Index | 2476 |
Starting at $86.90
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2. Fangwei Yang, Yixuan Li, Yunfei Xie, Weirong Yao, Fazheng Ren. (2022) Diethyl phosphate disrupts hypothalamus-pituitary-adrenal axis endocrine hormones via nuclear receptors GR and Nur77: Integration of evidences from in vivo, in vitro and in silico approaches. SCIENCE OF THE TOTAL ENVIRONMENT, 844 (157015). [PMID:35777568] [10.1016/j.scitotenv.2022.157015] |
3. Ye-ying Jiang, Rong-yun Wei, Kai Tang, Zhen Wang, Ning-hua Tan. (2022) Ginsenoside Rg1 promotes neurite growth of retinal ganglion cells through cAMP/PKA/CREB pathways. Journal of Ginseng Research, [PMID:38465221] [10.1016/j.jgr.2022.05.002] |
4. Chenhui Duan, Yanjun Fang, Jingran Sun, Zhenxin Li, Qiangqiang Wang, Jialei Bai, Hui Peng, Jun Liang, Zhixian Gao. (2020) Effects of fast food packaging plasticizers and their metabolites on steroid hormone synthesis in H295R cells. SCIENCE OF THE TOTAL ENVIRONMENT, 726 (138500). [PMID:32334352] [10.1016/j.scitotenv.2020.138500] |
5. Minchi Liu, Wenjun Qian, Selvaraj Subramaniyam, Shuang Liu, Wenkuan Xin. (2020) Denatonium enhanced the tone of denuded rat aorta via bitter taste receptor and phosphodiesterase activation. EUROPEAN JOURNAL OF PHARMACOLOGY, 872 (172951). [PMID:32006560] [10.1016/j.ejphar.2020.172951] |
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39. Gao Rongyin, Zhang Ximei, Zou Kun, Meng Duo, Lv Jinpeng. (2023) Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway. Frontiers in Pharmacology, 14 [PMID:36814484] [10.3389/fphar.2023.1081030] |
40. Fangwei Yang, Yixuan Li, Yunfei Xie, Weirong Yao, Fazheng Ren. (2022) Diethyl phosphate disrupts hypothalamus-pituitary-adrenal axis endocrine hormones via nuclear receptors GR and Nur77: Integration of evidences from in vivo, in vitro and in silico approaches. SCIENCE OF THE TOTAL ENVIRONMENT, 844 (157015). [PMID:35777568] [10.1016/j.scitotenv.2022.157015] |
41. Ye-ying Jiang, Rong-yun Wei, Kai Tang, Zhen Wang, Ning-hua Tan. (2022) Ginsenoside Rg1 promotes neurite growth of retinal ganglion cells through cAMP/PKA/CREB pathways. Journal of Ginseng Research, [PMID:38465221] [10.1016/j.jgr.2022.05.002] |
42. Chenhui Duan, Yanjun Fang, Jingran Sun, Zhenxin Li, Qiangqiang Wang, Jialei Bai, Hui Peng, Jun Liang, Zhixian Gao. (2020) Effects of fast food packaging plasticizers and their metabolites on steroid hormone synthesis in H295R cells. SCIENCE OF THE TOTAL ENVIRONMENT, 726 (138500). [PMID:32334352] [10.1016/j.scitotenv.2020.138500] |
43. Minchi Liu, Wenjun Qian, Selvaraj Subramaniyam, Shuang Liu, Wenkuan Xin. (2020) Denatonium enhanced the tone of denuded rat aorta via bitter taste receptor and phosphodiesterase activation. EUROPEAN JOURNAL OF PHARMACOLOGY, 872 (172951). [PMID:32006560] [10.1016/j.ejphar.2020.172951] |