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Fosbretabulin disodium - ≥99%, high purity , Tubulin inhibitor, CAS No.168555-66-6, Tubulin inhibitor

≥99%

CAS#: 168555-66-6
Formula: C₁₈H₁₉O₈P·2Na
Molecular Weight: 440.29
MDL number: MFCD00943911
PubChem CID: 6918309

Item Number

F129767

Grouped product items
SKU	Size	Availability	Price
F129767-10mg	10mg	In stock	$117.90
F129767-20mg	20mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$212.90
F129767-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$345.90
F129767-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$444.90
F129767-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,001.90

Vascular-disrupting and antineoplastic combretastatin prodrug

View related series

Element classified compounds Phosphorus compounds

Basic Description

Synonyms	Fosbretabulin disodium\|168555-66-6\|CA4DP\|Combretastatin A4 disodium phosphate\|CA 4P\|combretastatin A4 phosphate\|Zybrestat\|Fosbretabulin disodium [USAN]\|Fosbretabulin (disodium)\|Combretastatin A4 Phosphate Disodium Salt\|CA-4DP\|Fosbretabulin Disodium Salt\|F
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Combretastatin A4 Phosphate Disodium Salt is the salt form of Combretastatin A4, a phosphorylated microtubule depolymerizing molecule which induces tumor necrosis by regression of unstable nascent tumor neo-vessels. Studies suggest that Combretastatin A4
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	INHIBITOR
Mechanism of action	Tubulin inhibitor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	A microtubule depolymerizing molecule.

Associated Targets

TUBB1 Tclin Tubulin beta-1 chain 0 Activities

Discover Target: TUBB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TUBB2B Tclin Tubulin beta-2B chain 0 Activities

Discover Target: TUBB2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TUBA1A Tchem Tubulin alpha-1A chain 0 Activities

Discover Target: TUBA1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	disodium;[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate
INCHI	InChI=1S/C18H21O8P.2Na/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;;/h5-11H,1-4H3,(H2,19,20,21);;/q;2*+1/p-2/b6-5-;;
InChi Key	VXNQMUVMEIGUJW-XNOMRPDFSA-L
Canonical SMILES	COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]
Isomeric SMILES	COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]
WGK Germany	3
PubChem CID	6918309
Molecular Weight	440.29

Certificates

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Lot Number	Certificate Type	Date	Item
G1521069	Certificate of Analysis	Jan 09, 2023	F129767

Solubility

DMSO Water 28 mg/mL Ethanol

Sensitivity

Heat Sensitive

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