Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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F129767-10mg | 10mg | In stock | $117.90 | |
F129767-20mg | 20mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $212.90 | |
F129767-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $345.90 | |
F129767-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $444.90 | |
F129767-250mg | 250mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,001.90 |
Vascular-disrupting and antineoplastic combretastatin prodrug
Synonyms | CA 4P | CA-4P | MFCD00943911 | Zybrestat | Fosbretabulin Disodium Salt | PHENOL, 2-METHOXY-5-((1Z)-2-(3,4,5-TRIMETHOXYPHENYL)ETHENYL)-, DIHYDROGEN PHOSPHATE, DISODIUM SALT | 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 1-(Dihydrogen phosphat |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Combretastatin A4 Phosphate Disodium Salt is the salt form of Combretastatin A4, a phosphorylated microtubule depolymerizing molecule which induces tumor necrosis by regression of unstable nascent tumor neo-vessels. Studies suggest that Combretastatin A4 |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Action Type | INHIBITOR |
Mechanism of action | Tubulin inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | A microtubule depolymerizing molecule. |
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IUPAC Name | disodium;[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate |
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INCHI | InChI=1S/C18H21O8P.2Na/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;;/h5-11H,1-4H3,(H2,19,20,21);;/q;2*+1/p-2/b6-5-;; |
InChi Key | VXNQMUVMEIGUJW-XNOMRPDFSA-L |
Canonical SMILES | COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+] |
Isomeric SMILES | COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+] |
WGK Germany | 3 |
PubChem CID | 6918309 |
Molecular Weight | 440.29 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G1521069 | Certificate of Analysis | Jan 09, 2023 | F129767 |
Solubility | DMSO Water 28 mg/mL Ethanol |
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Sensitivity | Heat Sensitive |
WGK Germany | 3 |
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