Grouped product items

SKU

Size

Availability

Price

Qty

F610386-1mg

1mg

Available within 8-12 weeks(?)

$2,001.90

F610386-5mg

5mg

Available within 8-12 weeks(?)

$4,001.90

Basic Description

Synonyms	fosmidomycin \| 66508-53-0 \| Fosmidomycina \| Fosmidomycine \| Fosmidomycinum \| 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID \| Fosmidomycin [INN] \| {3-[formyl(hydroxy)amino]propyl}phosphonic acid \| 3-(N-hydroxyformamido)propylphosphonic acid \| CHEMBL203125 \| (3-(N-Hydroxyforma
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic inhibitor

Product Properties

ALogP	-2.2

Associated Targets(Human)

Homo sapiens (32628 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MRC5 (9203 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ddlB D-alanylalanine synthetase (66 Activities)

Discover Target: ddlB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase (389 Activities)

Discover Target: murA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

tmk Thymidylate kinase (360 Activities)

Discover Target: tmk

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

dxr 1-deoxyxylulose-5-phosphate reductoisomerase (147 Activities)

Discover Target: dxr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Micrococcus luteus (7463 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Acinetobacter (437 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycobacterium tuberculosis (203094 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecalis (29875 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mycolicibacterium smegmatis (8003 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium berghei (192651 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

murD UDP-N-acetylmuramoylalanine--D-glutamate ligase (1 Activities)

Discover Target: murD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase (191 Activities)

Discover Target: dxr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bacillus anthracis (2936 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DXR 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic (3 Activities)

Discover Target: DXR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rpmB 50S ribosomal protein L28 (2 Activities)

Discover Target: rpmB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rplB 50S ribosomal protein L2 (1 Activities)

Discover Target: rplB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

dapB 4-hydroxy-tetrahydrodipicolinate reductase (1 Activities)

Discover Target: dapB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

yefM Antitoxin YefM (1 Activities)

Discover Target: yefM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ftsX Cell division protein FtsX (1 Activities)

Discover Target: ftsX

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

mreC Cell shape-determining protein MreC (1 Activities)

Discover Target: mreC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

hemA Glutamyl-tRNA reductase (1 Activities)

Discover Target: hemA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

glxK Glycerate kinase (1 Activities)

Discover Target: glxK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

cca Multifunctional CCA protein (2 Activities)

Discover Target: cca

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fadL Outer membrane FadL protein (1 Activities)

Discover Target: fadL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

tolC Outer membrane protein TolC (10 Activities)

Discover Target: tolC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

mlaB Probable phospholipid ABC transporter-binding protein MlaB (1 Activities)

Discover Target: mlaB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

lgt Prolipoprotein diacylglyceryl transferase (1 Activities)

Discover Target: lgt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

baeR Transcriptional regulatory protein BaeR (1 Activities)

Discover Target: baeR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

tsaE tRNA threonylcarbamoyladenosine biosynthesis protein TsaE (6 Activities)

Discover Target: tsaE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

tilS tRNA(Ile)-lysidine synthase (1 Activities)

Discover Target: tilS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ydfW Uncharacterized protein ydfW in Qin prophage region (1 Activities)

Discover Target: ydfW

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ydiL Uncharacterized protein YdiL (3 Activities)

Discover Target: ydiL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium vinckei (20 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	3-[formyl(hydroxy)amino]propylphosphonic acid
INCHI	InChI=1S/C4H10NO5P/c6-4-5(7)2-1-3-11(8,9)10/h4,7H,1-3H2,(H2,8,9,10)
InChi Key	GJXWDTUCERCKIX-UHFFFAOYSA-N
Canonical SMILES	C(CN(C=O)O)CP(=O)(O)O
Isomeric SMILES	C(CN(C=O)O)CP(=O)(O)O
Alternate CAS	66508-53-0,66508-37-0 (mono-hydrochloride salt)
PubChem CID	572
MeSH Entry Terms	3-(N-formyl-N-hydroxy)aminopropylphosphonic acid;fosfidomycin;fosmidomycin;fosmidomycin monoammonium salt;fosmidomycin monopotassium salt;fosmidomycin monosodium salt;fosmidomycin sodium;fosmidomycin sodium salt;FR-31564;phosphonic acid, (3-(formylhydroxy
Molecular Weight	183.1

Database links

PubChem CID	572
ChEMBL Ligand	CHEMBL203125
CAS Registry No.	66508-53-0
RCSB PDB Ligand	FOM
Wikipedia	Fosmidomycin
ChEBI	CHEBI:443725
DrugBank Ligand	DB02948
Antibiotic DB	519

Certificates

Certificate of Analysis(COA)

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References

1. Jomaa H, Wiesner J, Sanderbrand S, Altincicek B, Weidemeyer C, Hintz M, Türbachova I, Eberl M, Zeidler J, Lichtenthaler HK et al.. (1999) Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs.. Science, 285 (5433): (1573-6). [PMID:10477522]
2. Lell B, Ruangweerayut R, Wiesner J, Missinou MA, Schindler A, Baranek T, Hintz M, Hutchinson D, Jomaa H, Kremsner PG. (2003) Fosmidomycin, a novel chemotherapeutic agent for malaria.. Antimicrob Agents Chemother, 47 (2): (735-8). [PMID:12543685]
3. Zhang B, Watts KM, Hodge D, Kemp LM, Hunstad DA, Hicks LM, Odom AR. (2011) A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling.. Biochemistry, 50 (17): (3570-7). [PMID:21438569]
4. Mombo-Ngoma G, Remppis J, Sievers M, Zoleko Manego R, Endamne L, Kabwende L, Veletzky L, Nguyen TT, Groger M, Lötsch F et al.. (2018) Efficacy and Safety of Fosmidomycin-Piperaquine as Nonartemisinin-Based Combination Therapy for Uncomplicated Falciparum Malaria: A Single-Arm, Age De-escalation Proof-of-Concept Study in Gabon.. Clin Infect Dis, 66 (12): (1823-1830). [PMID:29293893]

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fosmidomycin , 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic inhibitor, CAS No.66508-53-0, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic inhibitor