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SKU | Size | Availability | Price | Qty |
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F610386-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,001.90 | |
F610386-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $4,001.90 |
Synonyms | CHEBI:443725 | GTPL9739 | 3-(N-hydroxyformamido)propylphosphonic acid | Fosmidomycine [INN-French] | Fosmidomycinum | GJXWDTUCERCKIX-UHFFFAOYSA-N | [3-(N-hydroxyformamido)propyl]phosphonic acid | 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID | FR-31564 | |
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Specifications & Purity | Moligand™ |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic inhibitor |
ALogP | -2.2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-[formyl(hydroxy)amino]propylphosphonic acid |
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INCHI | InChI=1S/C4H10NO5P/c6-4-5(7)2-1-3-11(8,9)10/h4,7H,1-3H2,(H2,8,9,10) |
InChi Key | GJXWDTUCERCKIX-UHFFFAOYSA-N |
Canonical SMILES | C(CN(C=O)O)CP(=O)(O)O |
Isomeric SMILES | C(CN(C=O)O)CP(=O)(O)O |
Alternate CAS | 66508-53-0,66508-37-0 (mono-hydrochloride salt) |
PubChem CID | 572 |
MeSH Entry Terms | 3-(N-formyl-N-hydroxy)aminopropylphosphonic acid;fosfidomycin;fosmidomycin;fosmidomycin monoammonium salt;fosmidomycin monopotassium salt;fosmidomycin monosodium salt;fosmidomycin sodium;fosmidomycin sodium salt;FR-31564;phosphonic acid, (3-(formylhydroxy |
Molecular Weight | 183.1 |
PubChem CID | 572 |
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ChEMBL Ligand | CHEMBL203125 |
CAS Registry No. | 66508-53-0 |
RCSB PDB Ligand | FOM |
Wikipedia | Fosmidomycin |
ChEBI | CHEBI:443725 |
DrugBank Ligand | DB02948 |
Antibiotic DB | 519 |
Enter Lot Number to search for COA:
1. Jomaa H, Wiesner J, Sanderbrand S, Altincicek B, Weidemeyer C, Hintz M, Türbachova I, Eberl M, Zeidler J, Lichtenthaler HK et al.. (1999) Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs.. Science, 285 (5433): (1573-6). [PMID:10477522] |
2. Lell B, Ruangweerayut R, Wiesner J, Missinou MA, Schindler A, Baranek T, Hintz M, Hutchinson D, Jomaa H, Kremsner PG. (2003) Fosmidomycin, a novel chemotherapeutic agent for malaria.. Antimicrob Agents Chemother, 47 (2): (735-8). [PMID:12543685] |
3. Zhang B, Watts KM, Hodge D, Kemp LM, Hunstad DA, Hicks LM, Odom AR. (2011) A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling.. Biochemistry, 50 (17): (3570-7). [PMID:21438569] |
4. Mombo-Ngoma G, Remppis J, Sievers M, Zoleko Manego R, Endamne L, Kabwende L, Veletzky L, Nguyen TT, Groger M, Lötsch F et al.. (2018) Efficacy and Safety of Fosmidomycin-Piperaquine as Nonartemisinin-Based Combination Therapy for Uncomplicated Falciparum Malaria: A Single-Arm, Age De-escalation Proof-of-Concept Study in Gabon.. Clin Infect Dis, 66 (12): (1823-1830). [PMID:29293893] |